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General Information
Symbol
Dmel\cniAA12
Species
D. melanogaster
Name
FlyBase ID
FBal0034361
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cniAA
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G16310269A

Reported nucleotide change:
Amino acid change:

W87term | cni-PA; W87term | cni-PB; W87term | cni-PC

Reported amino acid change:

W87term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W87term.

Nucleotide substitution: G353A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eggs from cni1/cniAA12 females are ventralised (reduction of dorsal appendages), while the anterior and posterior structures differentiate correctly.

Heterozygosity for Df(2L)JS7 causes synthetic lethality in a cniAA12/cni1 background. Rare and severely malformed escapers can be recovered.

In 70% of cni1/cniAA12 mutants, the nucleus fails to move to the dorsal/anterior corner and is mislocalized at the posterior pole.

cni1/cniAA12 females lay ventralised eggs with apparently normal anterior-posterior polarity. The oocyte nucleus is localised normally in the egg chambers of these females.

Homozygous embryos exhibit a germline-dependent ventralised phenotype. cni1/cniAA12 transheterozygotes have mutant egg chambers.

Hemizygous eggs display possess residual dorsal appendage material and rarely a posterior micropyle. Most cniAA12/cni1 heterozygous embryos have one reduced dorsal appendage, few have a posterior micropyle, and a third of the eggs contain no embryos. twi expression domain show a duplication of the mesodermal analgen.

Strong ventralisation of embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Df(2L)JS7, cniAA12/cni1 has lethal phenotype, suppressible by cnircniUTR.PB

Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The synthetic lethality found in a synthetic cniAA12/cni1 and Df(2L)JS7 heterozygous background can be suppressed through expression of cnircniUTR.PB.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Intermediate cni allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (12)