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General Information
Symbol
Dmel\dppUAS.cSa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Staehling-Hampton
FlyBase ID
FBal0034429
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dpp, UAS.Dpp, UAS dpp, UAS-dpp.S, UASdpp, UAS-dpp42B.4
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a dpp cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

actin filament & tracheal tip cell & embryo, with Scer\GAL4btl.PS

embryonic/larval fat body & parasegment 4, with Scer\GAL4twi.PGa

embryonic/larval fat body & parasegment 5, with Scer\GAL4twi.PGa

embryonic/larval fat body & parasegment 6, with Scer\GAL4twi.PGa

embryonic/larval fat body & parasegment 6, with Scer\GAL4zen.Kr.PF

embryonic/larval fat body & parasegment 7, with Scer\GAL4twi.PGa

embryonic/larval fat body & parasegment 7, with Scer\GAL4zen.Kr.PF

embryonic/larval fat body & parasegment 8, with Scer\GAL4twi.PGa

embryonic/larval fat body & parasegment 8, with Scer\GAL4zen.Kr.PF

embryonic/larval fat body & parasegment 9, with Scer\GAL4twi.PGa

embryonic/larval fat body & parasegment 10, with Scer\GAL4twi.PGa

embryonic/larval fat body & parasegment 11, with Scer\GAL4twi.PGa

embryonic/larval fat body & parasegment 12, with Scer\GAL4twi.PGa

glial cell & eye | ectopic, with Scer\GAL4Act5C.PP

glial cell & eye | ectopic, with Scer\GAL4GMR.PF

parasegment 13 & mesoderm | ventral, with Scer\GAL4twi.PGa

scutellum & macrochaeta, with Scer\GAL4dpp.blk1

Detailed Description
Statement
Reference

Expression of dppScer\UAS.cSa under the control of Scer\GAL4twi.PG results in a substantial reduction in the number of primordial germ cells (PGCs)in the coalesced gonad. PGCs also display migration defects, with a significant fraction scattering through the embryo instead of making contact with the somatic gonad precursor cells.

Expression of dppScer\UAS.cSa in the germline, under the control of Scer\GAL4nos.UTR.T:Hsim\VP16, does not generate any abnormalities in somatic development. There are little if any defects in germ cell migration and most primordial germ cells are properly aligned with the somatic germ cell precursors in stage 13 embryos. These mutants exhibit a substantial reduction in the number of germ cells on the coalesced gonad, apparently due to apoptosis.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4vg.int2.1 results in extensive overproliferation in both anterior and posterior compartment cells in the wing disc.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4ap-md544 results in an increase in size of the wing disc.

Expression of dppScer\UAS.cSa in inner germarium sheath (IGS) cells under the control of Scer\GAL4C587 results in tumorous germaria that are filled with bam-negative GSC-like cells.

Clones in the wing disc expressing dppScer\UAS.cSa under the control of Scer\GAL4unspecified show overgrowth.

Expression of dppScer\UAS.cSa in every epidermal segment under the control of Scer\GAL4en-e16E, or in the posterior gut under the control of Scer\GAL4cad-md509, both result in mis-routing of the anterior pair of Malpighian tubules towards the ectopic source of dpp.

Females expressing dppScer\UAS.cSa under the control of Scer\GAL4GR1 produce eggs with enlarged dorsal appendages that are shifted towards the posterior compared to wild-type eggs.

Females expressing dppScer\UAS.cSa under the control of Scer\GAL4CY2 produce eggs showing an expansion of the operculum at the expense of the dorsal appendages.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4dpp.3KK results most of the wing tissue differentiating as vein.

The wings of dppScer\UAS.cSa; Scer\GAL4dpp.3KK flies are covered in ectopic vein tissue. This phenotype is rescued by dpps22/dpps4. The resulting flies have a milder shortvein phenotype than dpps22/dpps4 flies.

Overexpression of dppScer\UAS.cSa under the control of Scer\GAL4pb.PJ leads to extensive loss of pseudotracheae in the labial palps.

Mothers that express dppScer\UAS.cSa, driven by Scer\GAL4hs.PH following a heat shock, produce eggs that in 89% of cases have eggshells with giant opercula and reduced or absent dorsal appendages. Germaria from these females contain tumorous arrays of germline stem cells and aberrant follicles with large numbers of germ cells engulfed in the same follicular epithelium.

Eggs laid by dppScer\UAS.cSa; Scer\GAL4l(1)3At-PG150 mothers have an expanded operculum and a more posterior placement of the dorsal appendage bases.

Expression of dppScer\UAS.cSa, under the control of either Scer\GAL4B19, or Scer\GAL4eve.RN2 has no effect on the synaptic current amplitude in aCC/RP2 neurons compared to controls.

In dppScer\UAS.cSa; Scer\GAL4btl.PS embryos, terminal branch extension stalls. The actin core in these stalled branches is coiled.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4twi.PG causes mislocalisation of crystal cells to more posterior positions in the embryo than normal.

Testes of males expressing dppScer\UAS.cSa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 contain massive numbers of small early germ cells. The number of germ cells with a spectrosome dot (characteristic of gonialblasts) and of germ cells interconnected by small fusomes (characteristic of spermatogonial cysts) is increased compared to wild type. The testes contain large numbers of clusters of germ cells surrounded by somatic cyst cells. Clusters of more than 8 cells in a single cyst undergoing synchronous mitosis are often seen in the mutant testes (wild-type cysts never contain more than 8 cells undergoing synchronous division) as are cysts containing more than 16 spermatogonia interconnected by highly branched fusomes. The testes contain fewer spermatocytes than normal. Freshly eclosed males show signs of massive cell death in the more distal regions of the testes, while in testes of older males, often only dead or dying tissue is detected. Testes expressing dppScer\UAS.cSa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 show a statistically significant increase in the number of germline stem cells around the apical hub compared to wild type. The somatic hub is expanded compared to wild type in larval and adult testes of males expressing dppScer\UAS.cSa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 and in 38% of adult testes it is displaced away from the apical tip. In 6% of adults two somatic hubs are detected at different positions in the same testis.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in testes in which all germ cells resemble germ line stem cells and spermatogonia, and no spermatocytes or mature spermatids are present. The mutant testes contain a similar number of spectrosome-containing cells to wild-type testes, but the number of fusome-containing cells is much higher than wild type in the mutant testes (this suggests that the ectopic cells have spermatogonial identity). Cysts of germ cells in the mutant testis undergo synchronous mitotic division (another characteristic of spermatogonia), but the number of rounds of mitotic division exceeds the usual number of four. The mutant testes show significantly more cell death than wild-type testes.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4byn-Gal4 does not affect formation of the hindgut boundary cell rows or the posterior boundary cell ring. The anterior boundary cell ring is missing in these embryos.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4rho.PL causes dorsalisation of the ventral epidermis.

When expression is driven by Scer\GAL4prd.RG1 or Scer\GAL4en-e16E embryos are dorsalized.

Clones in the eye disc expressing dppScer\UAS.cSa under the control of Scer\GAL4Act5C.PI only induce neural differentiation along the margin of the eye discs.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4da.G32 results in embryos with a much wider amnioserosa and head epidermis than normal. Dorsolateral structures, such as the visual primordium, are relatively normal in size and shape, but are shifter to lateral or ventrolateral levels. Ventral tissues are partially missing. A high number of embryos heat pulsed between 3 and 5 hours post fertilisation (to express dppScer\UAS.cSa under the control of Scer\GAL4hs.PB) show a dorsalisation phenotype very similar to that caused by expression of dppScer\UAS.cSa under the control of Scer\GAL4da.G32. Later heat pulses have no effect on head patterning.

Expression of dppScer\UAS.cSa in the follicle cells using Scer\GAL4c532 at 29oC results in eggs which completely lack respiratory appendages and have an enlarged operculum which extends over more than half the dorsal side of the eggshell. Expression of dppScer\UAS.cSa in the follicle cells using Scer\GAL4c532 at 18oC results in eggs with an enlarged operculum surrounded by up to six respiratory appendages with significant variations in length and/or width.

When dppScer\UAS.cSa is driven by Scer\GAL4GMR.PF or Scer\GAL4Act5C.PP, a pronounced increase in the density of glial cell is seen in the entire optic system. In eye discs in which dppScer\UAS.cSa is expressed under the control of Scer\GAL4GMR.PF, the glial population migrates beyond its normal axonal boundary along the entire front. In milder cases, the glia migrate only a few rows beyond the normal anterior boundary of 2-4 rows posterior to the morphogenetic furrow. In a few cases they migrate even beyond the morphogenetic furrow. When clones of cells expressing dppScer\UAS.cSa under the control of Scer\GAL4Act5C.PP are made in the developing eye, ectopic differentiation of photoreceptors can sometimes be seen. In those eye discs where ectopic differentiation of photoreceptors is not seen, glial cells do not overshoot anteriorly, either in a broad front or a narrow stream. This mismigration is not preferentially directed toward the dppScer\UAS.cSa clones. In those eye discs where ectopic differentiation of photoreceptors is seen, glial cells migrate specifically to such patches.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4ptc-559.1 results in excessive growth of the hindgut in embryos. Excessive growth of the hindgut is not seen when dppScer\UAS.cSa is expressed under the control of Scer\GAL4byn-Gal4 or Scer\GAL4h-1J3.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4btl.PS changes the identity of the presumptive dorsal trunk cells in the embryonic tracheal system and causes them to adhere to and migrate with the dorsal branch cells and form narrow diameter tubes like the dorsal branch.

Eggs derived from females expressing dppScer\UAS.cSa under the control of Scer\GAL4hs.PB have an expanded operculum and reduced dorsal appendages. The eggshells are normal in other respects, and normal micropyles are formed at the extreme anterior of the eggshell. The mutant operculum generally has a normal organisation of large cell imprints surrounded by a raised "collar" structure. Expansion of the operculum always occurs over the dorsal side of the egg, indicating that dorsal-ventral patterning is unperturbed.

Expression of dppScer\UAS.cSa under the control of Scer\GAL430A results in a mirror image duplication of tissue at the anterior and overgrowth at the posterior in the wing.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4Dll-md23 increases the number of wing disc cells in the embryo.

Ectopic expression of dppScer\UAS.cSa under the control of Scer\GAL4E4 in a wild-type background has no visible effect on chorion structure. Females expressing dppScer\UAS.cSa under the control of Scer\GAL4E4 and treated with colchicine produce eggs with dorsal appendage material posteriorly.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4nos.PG results in embryos that lack ventral denticle belts.

Embryos expressing dppScer\UAS.cSa under the control of Scer\GAL469B do not show gross defects in dorsal closure. The embryos have poorly differentiated ventral cuticle. The ventral cuticle does not have dorsal hairs, indicating that it is not transformed to a dorsal fate. Wild-type patterns of asymmetric gastrulation are seen in these embryos.

Expression of dppScer\UAS.cSa under the control of Scer\GAL430A does not result in the induction of ectopic retinal cells in the wing disc.

When expression is driven by Scer\GAL4arm.PS the spiracular chamber does not invaginate, though all the structures of the spiracular chamber (trachea link, filzkorper, spiracular hairs) differentiate, as determined by cell shape markers.

Expression of dppScer\UAS.cSa under the control of Scer\GAL4vg.int2.1 leads to an enlargement of the wing blade along the anterior/posterior axis in the wing disc.

When expression is driven by Scer\GAL4T155 a large lateral region of the tergite is transformed to pleural identity, while the sternite is reduced to approximately 25% of its normal size. The number of bristles remains unchanged. The piment band of the tergite is broadened. No stronger effect can be caused by increasing the dosage of dppScer\UAS.cSa. A similar but weaker phenotype is seen when expression is driven by Scer\GAL4dpp.blk1. Clones induced in the sternite or tergite, driven by Scer\GAL4αTub84B.PP, cause nonautonomous transformations.

Wing discs expressing dppScer\UAS.cSa under the control of Scer\GAL430A grow abnormally large.

Expression driven ubiquitously with Scer\GAL4hs.PB causes an inhibition of S phase in the eye disc and the antennal disc.

Neither Scer\GAL4C-765- nor Scer\GAL4dpp.blk1-mediated expression induces leg to wing transdetermination.

Scer\GAL4zen.Kr.PF-mediated expression represses fat body development in parasegments 6-8. Scer\GAL4twi.PGa-mediated expression represses fat body development in parasegments 4-12 but promotes it in parasegment 13 resulting in ectopic fat body precursors in the ventral mesoderm. These cells lie in the mesoderm above the invaginating posterior midgut.

When expressed under the influence of Scer\GAL4how-24B, midgut constrictions are affected.

Embryos expressing dppScer\UAS.cSa under the control of Scer\GAL4how-24B lack the first and third midgut constrictions, and have an abnormally deep second midgut constriction.

Scer\GAL4c532-mediated expression generates eggs with more posteriorly located and malformed dorsal appendages. Sometimes more than two chorionic appendages are produced in one egg.

Scer\GAL4-mediated lethality occurs during larval and pupal periods. Scer\GAL4E132-mediated expression causes the development of ectopic morphogenetic furrows (MF). Most ectopic MFs initiated at the anterior edge of the eye disc and propogated posteriorly, few initiate from the ventral margin and propogate dorsally. In some discs the ommatidial array extends into regions of that disc that normally give rise to the head cuticle surrounding the compound eye. The normal and ectopic eye fields fuse forming a lawn of neuronal clusters covering essentially the whole disc. dpp induced clones in the eye disc (expressed from Scer\GAL4Act5C.PP) cause ectopic morphogenetic furrows that propogate posteriorly from the anterior margin. Overgrowth of the anterior eye disc occurs frequently and in some cases a new eye disc is generated. Study of the clone phenotypes confirms that specific regions of the eye are competent to respond to dpp and ectopic dpp exercises its effect at a considerable distance.

Scer\GAL4btl.PS-mediated expression diverts cells of the dorsal trunk and visceral branch primordia to the dorsal branch.

Produces ectopic vein tissue in the wing when expressed using Scer\GAL4C-580 at 17oC or 25oC.

When expression is driven by Scer\GAL4hs.PB, embryos show shifts in the dorsal fate map that are less extreme than those caused by Scer\GAL4ptc-559.1. However there are no changes in dorsal pattern across the segment, the 1o, 2o, 3o and 4o cell types are all present in either case.

When expressed from Scer\GAL4dpp.blk1, wing discs are greatly expanded along the anteroposterior axis of the wing blade region, though the dorsal, notal region remains unaffected.

Scer\GAL4dpp.blk1 induced overexpression of dpp induces foreleg bifurcations and foreleg fusions in a dose-dependent manner. Intermediate increase in dpp expression causes supernumerary bifurcations to emerge from the anterior-ventral side of the leg that consist of anterior-ventral leg structures. Higher levels of dpp expression cause fused proximal segments and foreleg pairs become fused along the entire proximal-distal axis. The second and third leg disc pairs exhibit a low frequency of incomplete ventral bifurcations. An intermediate increase in dpp expression has little effect on wing and thorax patterning, except for thickening of the anterior cross vein. Higher levels of dpp expression causes defects in the scutellum. At the highest temperature flies are recovered at pharate adults with the most severely reduced scutellum have wing duplications. The duplications arise from the posterior hinge region and posteior wing blade structures.

When expressed with Scer\GAL469B ventral cells are dorsalised. Expression with Scer\GAL4C-765 results in large overproliferating discs.

Failure of all of the midgut morphogenetic events except formation of constriction 2.

Expression induced by Scer\GAL469B causes the ventral denticle belts to be replaced by fine hairs characteristic of the dorsal surface.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference
Enhancer of
NOT Enhancer of
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Reference
Other
Phenotype Manifest In
Enhanced by
Suppressed by
NOT suppressed by
Statement
Reference
Enhancer of
NOT Enhancer of
Suppressor of
NOT Suppressor of
Other
Statement
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Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of lwrScer\UAS.cAa with dppScer\UAS.cSa in primordial germ cells, under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 does not restore the number of primoridal germ cells to wild-type, but does alter the distribution of these cells to a more wild-type manner.

Expression of either wgScer\UAS.cLa or dppScer\UAS.cSa does not enhance the overproliferation seen in wing discs expressing EgfrScer\UAS.cBa under the control of Scer\GAL4ap-md544. However, co-expression of wgScer\UAS.cLa and dppScer\UAS.cSa with EgfrScer\UAS.cBa produces tumors consisting of epithelial and mesenchymal cell populations and showing loss of epithelial integrity.

Co-expression of dppScer\UAS.cSa results in enlarged wing discs containing a larger field (30-40% of disc surface area) of differentiating ectopic eye precursors compared to expression of eyScer\UAS.cHa alone under the control of Scer\GAL4ap-md544.

Eggs derived from females expressing dppScer\UAS.cSa under the control of Scer\GAL4CY2 in a grk2B6/grkHF background have misshaped micropyles, show the loss of the collar that normally separates the operculum from the rest of the chorion and show a reduction in egg diameter.

Co-expression of dppScer\UAS.cSa and grkScer\UAS.cBa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 and Scer\GAL4GR1 results in eggs with a large anterior operculum followed by a symmetrical band of dorsal appendage material.

Co-expression of dppScer\UAS.cSa and grkScer\UAS.cBa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 and Scer\GAL4CY2 results in eggs with an expansion of the operculum at the expense of dorsal appendage material.

The precocious differentiation of primordial germ cells which is seen in nos18/Df(3R)Dl-FX3 larval ovaries is partially suppressed by expression of dppScer\UAS.cSa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

When dppScer\UAS.cSa, hhScer\UAS.cAa and eyScer\UAS.cHa are co-expressed in clones (driven by Scer\GAL4Act5C.PI), very strong overgrowth and distorted morphology is seen in the wing disc. Co-expression of dppScer\UAS.cSa, hhScer\UAS.cAa and eyScer\UAS.cHa driven by Scer\GAL4bi-omb-Gal4, causes a high larval lethality at 25oC.

When dppScer\UAS.cSa and eyScer\UAS.cHa are driven by Scer\GAL430A, photoreceptor differentiation is induced in the wing disc, only in the posterior compartment. When dppScer\UAS.cSa, eyScer\UAS.cHa and hhScer\UAS.cCa are driven by Scer\GAL430A, photoreceptor differentiation is induced in both compartments of the wing disc. When dppScer\UAS.cSa, eyaScer\UAS.cPa and eyScer\UAS.cHa are driven by Scer\GAL430A, photoreceptor differentiation is induced in both compartments of the wing disc. The addition of soScer\UAS.cPa increases the penetrance of this phenotype. The addition of dppScer\UAS.cSa or eyaScer\UAS.cPa (driven by Scer\GAL4ey.PB) to animals with smoD16 clones in the eye disc has no effect on the photoreceptor differentiation phenotype seen in eye discs. The delayed progression of the morphogenetic furrow is also not affected. The addition of dppScer\UAS.cSa and eyaScer\UAS.cPa (driven by Scer\GAL4ey.PB) to animals with smoD16 clones in the eye disc, fully suppresses photoreceptor differentiation phenotype seen in eye discs. The delayed progression of the morphogenetic furrow is also rescued. The addition of dppScer\UAS.cSa and eyaScer\UAS.cPa (driven by Scer\GAL4ey.PB) to animals with smoD16 clones in the eye disc, fully suppresses photoreceptor differentiation phenotype seen in eye discs. The delayed progression of the morphogenetic furrow is also rescued. If soScer\UAS.cPa is also added, posterior margin clones are still rescued, although ectopic anterior furrows are induced with high frequency. The addition of soScer\UAS.cPa and dppScer\UAS.cSa (driven by Scer\GAL4ey.PB) to animals with smoD16 clones in the eye disc has no effect on the photoreceptor differentiation phenotype seen in eye discs.

Co-expression of dppScer\UAS.cSa does not rescue progression of the morphogenetic furrow in animals expressing wgwg.3'UTR.Scer\UAS under the control of Scer\GAL4dpp.blk1.

Clones in the eye disc expressing both dppScer\UAS.cSa and DlScer\UAS.cJa under the control of Scer\GAL4Act5C.PI result in neural differentiation in all regions anterior to the morphogenetic furrow. Neural differentiation is induced in all the cells surrounding the clone.

The wing phenotype caused by expression of dppScer\UAS.cSa under the control of Scer\GAL430A is mildly suppressed by Su(hh)II, Su(hh)IIII or Su(hh)IVIV, strongly suppressed by Su(hh)VIIVII and not suppressed by Su(hh)IIIIII, Su(hh)VV or Su(hh)VIVI.

When dppScer\UAS.cSa is expressed under the control of Scer\GAL4en-e16E in D3/Df(3L)fz-GS1a embryos, significant, though variable rescue of the D3/Df(3L)fz-GS1a hindgut phenotype is seen.

Enhances the ectopic retinal development phenotype in the wing and haltere discs caused by expression of eyScer\UAS.cHa under the control of Scer\GAL430A.

Coexpression of dppScer\UAS.cSa and wgScer\UAS.cGa under the control of Scer\GAL4vg.int2.1 leads to a pronounced extension of the wing blade towards the notum in the wing disc. In some cases, the development of up to 8 wing blades, all with a common origin over a point ventral to the notum, is seen.

When dppScer\UAS.cSa and wgScer\UAS.cLa are coexpressed via Scer\GAL4T155 in pupae, abdominal pattern is restored to wild type, indicating that pleural and tergite/sternite fates are specified by the balance between competing wg and dpp activities. When co-expression of EgfrDN.Scer\UAS and dppScer\UAS.cSa is driven by Scer\GAL4T155 the tergite is reduced to a very small patch near the dorsal midline and the lateral tergite is completely transformed to pleura. These effects are not due to reduced histoblast proliferation.

wgAct5C.PS; Scer\GAL4dpp.blk1/dppScer\UAS.cSa flies die before adulthood, transplanted second leg discs exhibit wg-induced transdetermination, legs with wing tissue. Coxa, trochanter and femur segments are reduced. Ventral wing hinge structures are observed at opposite regions within the mesothoracic leg tissue.

dppScer\UAS.cSa under the influence of Scer\GAL4how-24B, gut morphology is more normal than for dppScer\UAS.cSa, Scer\GAL4how-24B mutants alone.

When EgfrDN.Scer\UAS is expressed in combination with dppScer\UAS.cSa under the influence of Scer\GAL4how-24B, gut morphology is more normal than for dppScer\UAS.cSa, Scer\GAL4how-24B mutants alone.

The first midgut constriction is restored in more than 90% of cases of embryos expressing dppScer\UAS.cSa under the control of Scer\GAL4how-24B if the embryo also carries Med2/Med4. In all embryos where the first constriction is restored, there is also a significant rescue of the third midgut constriction.

vn1 rhove-1 double homozygotes lack all longitudinal wing veins. Vein tissue differentiates in vn1 rhove-1 double homozygotes when dppScer\UAS.cSa is expressed in these flies using Scer\GAL4C-580.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Expression of Scer\GAL4dpp.blk1 in a dppd-blk background rescues the mutant eye phenotype, restoring the number of ommatidia to approximately that of wild type eyes and in a dppd6 background rescues the mutant eye and wing phenotypes.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Staehling-Hampton.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
dppScer\UAS.cSa
dppUAS.cSa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Staehling-Hampton
Secondary FlyBase IDs
    References (123)