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General Information
Symbol
Dmel\enCX1
Species
D. melanogaster
Name
FlyBase ID
FBal0034500
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
enCXI
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Breakpoint mutation within the first intron or exon.

    Maps to approximate coordinate -14 of the inv-en region. The rearrangement associated wth this allele severs the en transcription unit in either the first exon or the first intron, separating the sequences that control expression in the hindgut and clypeolabrum from those that control expression in the ectoderm and nervous system.

    Inversion breakpoint within the transcription unit.

    A rearrangement that truncates the en transcription unit.

    Caused by aberration
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous embryos lack antennal sense organs.

    Double mutant phenotype with CrebA mutants is additive.

    Strong mutant phenotype. Mutant embryos develop extreme denticle belt fusions and show a severe segmentation phenotype. This phenotype is comparable to that of embryos deleted for both en and inv. enCX1/en1 adults have severely disrupted wings, legs with fused tarsal segments and a low frequency of eclosion.

    Pair-wise fusions of thoracic and abdominal denticle bands. Expression of P{31Rg-en} in enCX1 mutant background allows restoration of naked cuticle between fused denticle bands (good rescue of early en function), as well as near normal denticle patterns within bands (row 1 denticles are rarely rescued - partial rescue of late en function). Expression of P{enF->E} or P{enΔeh1} allows only very weak rescue; restoration of some naked cuticle between ventral denticle bands.

    Transheterozygotes with Df(3R)slo8 produce flies with abnormal wings.

    Severe en phenotype.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressed by
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference

    Agam\eninv-12A rescues many aspects of the embryonic phenotype. Agam\enen-12A-5R rescue causes slight defects in the posterior compartments of the wings, both sexes are fertile.

    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Strong en allele.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (18)