Allele Dmel\fng²

General Information
Symbol	Dmel\fng²	Species	D. melanogaster
Name		FlyBase ID	FBal0034613
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\fng

Allele class	hypomorph
Mutagen	ethyl methanesulfonate
Nature of the Allele
Allele class	hypomorph (Irvine and Wieschaus, 1994, Grammont and Irvine, 2001)
Mutagen	ethyl methanesulfonate (Irvine and Wieschaus, 1994)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: L398Q. Nucleotide substitution: T?A. (Correia et al., 2003)
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	viable (Grammont and Irvine, 2001) semi-viable (Correia et al., 2003) semi-viable (with Df(3L)ri-XT1) (Correia et al., 2003) semi-viable (with fng^35UZ-1) (Correia et al., 2003) semi-viable (with fng¹²⁹) (Correia et al., 2003) semi-viable (with fng¹³) (Correia et al., 2003) semi-viable (with fng¹⁴) (Correia et al., 2003) semi-viable (with fng⁵²) (Correia et al., 2003) semi-viable (with fng⁷) (Correia et al., 2003) semi-viable (with fng⁸) (Correia et al., 2003) semi-viable (with fng⁸⁰) (Correia et al., 2003) semi-viable (with fng^M69) (Correia et al., 2003) semi-viable (with fng^L83) (Correia et al., 2003) semi-viable (with fng^L81) (Correia et al., 2003) semi-viable (with fng^L73) (Correia et al., 2003) semi-viable (with fng^L19) (Correia et al., 2003) semi-viable (with fng⁵) (Correia et al., 2003) semi-viable (with fng³) (Correia et al., 2003) semi-viable (with fng¹) (Correia et al., 2003) semi-viable (with fng¹¹) (Correia et al., 2003) visible \| recessive (Irvine and Wieschaus, 1994)
Phenotype Manifest In
	wing (with fng^L19) (Correia et al., 2003) wing (with fng³) (Correia et al., 2003) wing (with fng⁸⁰) (Correia et al., 2003) ovary (with fng⁸⁰) (Grammont and Irvine, 2001) interfollicle cell (with fng⁸⁰) (Grammont and Irvine, 2001) follicle cell (with fng⁸⁰) (Grammont and Irvine, 2001) ovary (with fng^M69) (Grammont and Irvine, 2001) interfollicle cell (with fng^M69) (Grammont and Irvine, 2001) follicle cell (with fng^M69) (Grammont and Irvine, 2001) wing (with fng^M69) (Correia et al., 2003) wing (with fng⁵²) (Correia et al., 2003) wing (with fng¹¹) (Correia et al., 2003) wing (Irvine and Wieschaus, 1994, Correia et al., 2003) ovary (Grammont and Irvine, 2001) follicle cell (Grammont and Irvine, 2001) wing (with fng^L83) (Correia et al., 2003) wing (with fng¹³) (Correia et al., 2003) ovary (with fng¹³) (Grammont and Irvine, 2001) interfollicle cell (with fng¹³) (Grammont and Irvine, 2001) follicle cell (with fng¹³) (Grammont and Irvine, 2001) wing (with fng¹⁴) (Correia et al., 2003) wing (with Df(3L)ri-XT1) (Correia et al., 2003) wing (with fng^35UZ-1) (Correia et al., 2003) wing (with fng¹²⁹) (Correia et al., 2003) wing (with fng¹) (Correia et al., 2003) wing (with fng⁵) (Correia et al., 2003) wing (with fng⁷) (Correia et al., 2003) wing (with fng⁸) (Correia et al., 2003) wing (with fng^L73) (Correia et al., 2003) wing (with fng^L81) (Correia et al., 2003)
Detailed Description
	Statement Reference Loss of tissue from the wing margin. (Irvine and Wieschaus, 1994) Homozygous females have ovaries showing 0% compound follicles, 0% with long stalks 9% of follicles have abnormal epithelium. Transheterozygous fng²/fng⁸⁰ females have ovaries showing 0% compound follicles, 26% with long stalks 48% of follicles have abnormal epithelium. Transheterozygous fng²/fng^M69 females have ovaries showing 0% compound follicles, 11% with long stalks 37% of follicles have abnormal epithelium. Transheterozygous fng²/fng¹³ females have ovaries showing 0% compound follicles, 12% with long stalks 42% of follicles have abnormal epithelium. Where follicles do not include the usual 16 germline cells, those with more than usual germline cells lie next to those with fewer than usual germline cells. Along the length of the entire ovariole the oocyte:nurse cell ratio is normal. The abnormalities of number of germline cells in each egg chamber is caused by defects in the enclosure of germline cysts by somatic follicle cells. The long stalk phenotype is sometimes accompanied by a stalk disorganization phenotype. (Grammont and Irvine, 2001) Df(3L)ri-XT1/fng² animals that survive to adulthood exhibit a moderate wing phenotype. fng²/fng⁸⁰ animals that survive to adulthood exhibit a weak wing phenotype. fng²/fng¹³ animals that survive to adulthood exhibit a moderate wing phenotype. fng²/fng^M69 animals that survive to adulthood when grown at 18^oC exhibit a moderate wing phenotype. fng²/fng⁵² animals that survive to adulthood exhibit a moderate wing phenotype. fng²/fng² animals that survive to adulthood exhibit a weak wing phenotype. (Correia et al., 2003)
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	fng¹³ (Grammont and Irvine, 2001) fng⁸⁰ (Grammont and Irvine, 2001) fng^M69 (Grammont and Irvine, 2001)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	One of seven EMS induced alleles recovered. (Irvine and Wieschaus, 1994) Phenotypic analysis suggests the following allelic series: fng^M69 > fng⁵² > fng². (Correia et al., 2003)
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	fng²
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Correia et al., 2003, Proc. Natl. Acad. Sci. USA 100(11): 6404--6409 Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila. [FBrf0159701] Grammont and Irvine, 2001, Development 128(12): 2243--2253 fringe and Notch specify polar cell fate during Drosophila oogenesis. [FBrf0137222] Irvine and Wieschaus, 1994, Cell 79(4): 595--606 fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. [FBrf0076041]

Allele Dmel\fng2

Allele Dmel\fng²