crpk10415 mutant larvae exhibit a significant reduction in the number of tracheal terminal branches. The early stages of tracheal development are normal but the terminal branches seldom extend beyond the cell body. The dorsal, visceral, ganglionic and lateral G terminal branches are all similarly affected. Terminal cells in the crpk10415 mutant larvae extend fewer cytoplasmic processes than normal and many of the processes that form do not develop an air-filled lumen. The crpk10415 mutant also affects the outgrowth of the first terminal branches of dorsal branches that form at the end of embryogenesis. Other tissues, including the gut, central nervous system, salivary glands and imaginal discs are grossly intact.
The embryonic and larval tracheal phenotypes seen in crpk10415 are equally as severe as those seen in crpk10415/Df(2L)r10. No phenotypes are observed in crpk10415 heterozygotes.
crpk10415/crpk00809 mutant larvae exhibit tracheal phenotypes that are as severe as either mutant with Df(2L)r10.
Lethality occurs during third instar larval or pupal stages. Mutants do not show any visible disc abnormalities.