FB2025_01 , released February 20, 2025
Allele: Dmel\Syx5AR113
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General Information
Symbol
Dmel\Syx5AR113
Species
D. melanogaster
Name
FlyBase ID
FBal0035013
Feature type
allele
Associated gene
Dmel\Syx5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Roote, 1995.5.4)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q153term.

(Xu et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:16,308,655..16,308,655 [+]
Nucleotide change:

C16308655T

Amino acid change:

Q310term | Syx5-PA; Q310term | Syx5-PB

Reported amino acid change:

Q153term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Xu et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Syx5AR113 heterozygotes show increased dietary copper tolerance compared with wild-type. Heterozygous Syx5AR113 larvae accumulate less copper than wild-type on both basal and copper-supplemented diets. They accumulate more zinc than wild-type on zinc-supplemented diet, but tolerance to excess zinc is unaffected.

      (Norgate et al., 2010)

      Syx5EP2313/Syx5AR113 mutant males (with no Scer\GAL4 driver) have no motile sperm and appear to be defective in spermatid elongation. Mutant testes contain predominantly large, oval cysts and a few elongated bundles. Mutant testes also have abnormally large mitochondrial derivatives that are associated with multiple nuclei, indicative of a failure in cytokinesis. Mutant testes also exhibit an accumulation of unusual ovoid spermatid cysts.

      (Xu et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Syx5AR113/Syx5[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of ruPLLb

      (Yogev et al., 2010)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Syx5AR113/Syx5[+] is a suppressor of optic cartridge | third instar larval stage phenotype of ruPLLb

      (Yogev et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of Syx5AR113 partially rescues the lamina cartridge neuron differentiation defects seen in the eye discs of ruPLLb mutant third instar larvae. Neuronal markers are detected in a small population of cells at the posterior of the lamina.

      (Yogev et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Syx5AA73

      (Xu et al., 2002)

      Syx5AE48

      (Xu et al., 2002)

      Syx5AE73

      (Xu et al., 2002)
      Comments

      Complementation testing of Syx5AR113, Syx5AA73, Syx5AE48 and Syx5AE73 results in lethality.

      (Xu et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      S. Roth.

      (Roote, 1995.5.4)
      Comments
      Comments

      Phenotypic data included in FBrf0051973.

      (Roote, 1995.5.4)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      AR113
      (Schotman et al., 2008)
      Sed5AR113
      Syx5AR113
      (Allen et al., 2021, Norgate et al., 2010)
      Syx5[AR113]
      (Takáts et al., 2018)
      dSyx5AR113
      (Xu et al., 2002)
      l(2)35FfAR113
      (Ashburner et al., 1999.10.12, Roote, 1995.5.4)
      sed5AR113
      (Yogev et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)