Open Close
General Information
Symbol
Dmel\lawcp1
Species
D. melanogaster
Name
FlyBase ID
FBal0035190
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion 400bp upstream of lawc.

Insertion of a double copy of a P-element.

Insertion components
P{}lawc-p1b
P{}lawc-p1a
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

35-65% of mutant larvae survive to adulthood.

Mutants show an arista-to-leg transformation.

Phenotype similar to that of the lost alleles scr1 and bwl1 with respect to wing and bristle phenotypes, but differs in showing homeotic transformation arista to tarsus not described for scr1 and bwl1.

All lawcp1 flies show partial transformation of the arista into leg, which is manifested as a thickening of the arista. 1% of flies show complete transformation into leg, such that leg segments and tarsal claws are seen instead of arista tissue. Flies often have ectopic bristles on the scutellum and thorax, and the wings are held apart with multiple incisions in the margins, especially along the posterior margin. The mutant phenotype is stronger in males than females. Most lawcp1/Df(1)RA2 females die as early larvae. The 10% that do eclose have an enhanced lawc mutant phenotype compared to lawcp1 flies that includes strong arista to leg transformation, many ectopic bristles and larger wing margin incisions. The 3% of lawcEF520/lawcp1 females that eclose have an enhanced lawc mutant phenotype compared to lawcp1 flies that includes an arista to leg transformation.

Temperature sensitive periods for the formation of extra macrochaetae are distributed within larval instars II and III. Different types of macrochaetae differ from one another in their temperature sensitivity.

Phenotype is 1% penetrant for complete transformation of arista to leg and fully penetrant for partial transformation, i.e. thickened aristae. Occasionally extra bristles appear on the thorax and scutellum, the wings are hyper-extended with incisions in their margins and the abdominal markings are abnormal.

Wings have a ct phenotype, are wide apart and slightly raised. Additional bristles are present on the head, thorax and scutellum. Rough eye phenotype. Transformation of arista in tarsus and distortion of distal leg regions.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

lawcp1 has visible phenotype, enhanceable by Pros26[+]/Prosβ6unspecified

lawcp1 has visible | homeotic phenotype, enhanceable by trxB11/trx[+]/ash1[+]/ash117

lawcp1 has visible | homeotic phenotype, enhanceable by trx[+]/trxE2/brm[+]/brm2

brm2, lawcp1 has visible | homeotic phenotype, enhanceable by trxE2

Enhancer of
Statement
Reference

lawcp1/lawc[+] is an enhancer of visible | dominant | homeotic phenotype of brm2, trx[+]/trxE2

lawcp1/lawc[+] is an enhancer of visible | dominant | homeotic phenotype of ash1[+]/ash117, trxB11

lawcp1/lawc[+] is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

lawcp1/lawc[+] is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

NOT Enhancer of
Statement
Reference

lawcp1 is a non-enhancer of visible | homeotic phenotype of brm2

lawcp1 is a non-enhancer of visible | dominant | homeotic phenotype of trxB11

lawcp1 is a non-enhancer of visible | dominant | homeotic phenotype of brm2

lawcp1 is a non-enhancer of visible | dominant | homeotic phenotype of ash117

lawcp1 is a non-enhancer of visible | homeotic phenotype of trxB11

Suppressor of
Statement
Reference

lawcp1 is a suppressor of abnormal body color phenotype of mod(mdg4)ul, y2

lawcp1 is a suppressor of visible | dominant | homeotic phenotype of Pc4

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

lawcp1 has arista phenotype, enhanceable by Pros26[+]/Prosβ6unspecified

lawcp1 has leg | ectopic phenotype, enhanceable by Pros26[+]/Prosβ6unspecified

lawcp1 has arista phenotype, enhanceable by trxB11/trx[+]/ash1[+]/ash117

lawcp1 has arista phenotype, enhanceable by trx[+]/trxE2/brm[+]/brm2

brm2, lawcp1 has arista phenotype, enhanceable by trxE2

Enhancer of
Statement
Reference

lawcp1/lawc[+] is an enhancer of metathoracic leg phenotype of brm[+]/brm2, trxE2

lawcp1/lawc[+] is an enhancer of haltere phenotype of ash1[+]/ash117, trxB11

lawcp1/lawc[+] is an enhancer of metathoracic leg phenotype of ash1[+]/ash117, trxB11

lawcp1/lawc[+] is an enhancer of haltere phenotype of ash117, trxB11/trx[+]

lawcp1/lawc[+] is an enhancer of metathoracic leg phenotype of ash117, trxB11/trx[+]

lawcp1/lawc[+] is an enhancer of haltere phenotype of brm2, trxB11/trx[+]

lawcp1/lawc[+] is an enhancer of metathoracic leg phenotype of brm2, trxB11/trx[+]

lawcp1/lawc[+] is an enhancer of haltere phenotype of brm[+]/brm2, trxE2

NOT Enhancer of
Statement
Reference

lawcp1/lawc[+] is a non-enhancer of wing vein | ectopic phenotype of Snr1E1

Suppressor of
Statement
Reference

lawcp1 is a suppressor of phenotype of mod(mdg4)ul

lawcp1 is a suppressor of adult abdomen | male phenotype of mod(mdg4)ul, y2

lawcp1 is a suppressor of prothoracic leg phenotype of Pc4

lawcp1 is a suppressor of mesothoracic leg phenotype of Pc4

NOT Suppressor of
Statement
Reference

lawcp1/lawc[+] is a non-suppressor of wing vein | ectopic phenotype of Snr1E1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Pros26unspecified/+ significantly enhances the arista-to-leg transformation seen in lawcp1 mutants.

Does not enhance the frequency of homeotic transformations of trxB11, brm2 or ash117 single heterozygotes. The frequency and severity of homeotic transformations (such as haltere to wing or third leg to second leg transformations) in trxB11 ash117 or brm2 trxE2 double heterozygotes is dominantly enhanced by lawcp1. The enhancement is stronger in a lawcp1 maternal background. The arista to leg transformation characteristic of lawcp1 is also enhanced in these flies. lawcp1/lawcEF520 females are viable. However, in combination with trxB11, brm2 or ash117, lawcp1/lawcEF520 results in lethality. lawcp1/Df(1)RA2 females are viable. However, in combination with trxB11, brm2 or ash117, lawcp1/Df(1)RA2 results in lethality. The ectopic sex combs seen on the second and/or third legs of Df(3L)Pc-MK/+ or Pc4/+ males are largely suppressed by lawcp1. Body colour: the abdominal pigment of y2 males is lighter than normal, but uniformly distributed in the last two abdominal segments. y2; mod(mdg4)ul males have variegated abdominal pigmentation with individual spots of wild-type dark pigment against a lighter pigmented background in the last two abdominal segments. This variegated phenotype is suppressed if the flies are also carrying lawcp1; the areas of lighter pigmentation increase at the expense of darkly pigmented regions so that the phenotype is closer to y2 rather than y2 ; mod(mdg4)ul flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

lawcp1 is partially rescued by lawct6.5

Comments

The arista-to-leg transformation seen in lawcp1 flies is reduced in frequency by 75% if they are also carrying lawct6.5. lawct6.5 also rescues the lethality of lawcp1. The ability of lawcp1 to enhance the cut wing phenotype of ctn is partially suppressed by lawct6.5; there is a 44% in the frequency of lawcp1 ctn flies with very cut wings if they are also carrying lawct6.5.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Enhances the mutant phenotype of sc alleles i.e. bristle number is reduced compared to the number of bristles in e.g. sc4. Deficiency for Pc causes an enhancement of the lawcp1 bristle phenotype: more duplications of bristles on the thorax and scutellum occurs than on lawcp1 alone.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0035189
References (22)