adult thorax & macrochaeta
Does not enhance the frequency of homeotic transformations of trxB11, brm2 or ash117 single heterozygotes. The frequency and severity of homeotic transformations (such as haltere to wing or third leg to second leg transformations) in trxB11 ash117 or brm2 trxE2 double heterozygotes is dominantly enhanced by lawcp1. The enhancement is stronger in a lawcp1 maternal background. The arista to leg transformation characteristic of lawcp1 is also enhanced in these flies. lawcp1/lawcEF520 females are viable. However, in combination with trxB11, brm2 or ash117, lawcp1/lawcEF520 results in lethality. lawcp1/Df(1)RA2 females are viable. However, in combination with trxB11, brm2 or ash117, lawcp1/Df(1)RA2 results in lethality. The ectopic sex combs seen on the second and/or third legs of Df(3L)Pc-MK/+ or Pc4/+ males are largely suppressed by lawcp1. Body colour: the abdominal pigment of y2 males is lighter than normal, but uniformly distributed in the last two abdominal segments. y2; mod(mdg4)ul males have variegated abdominal pigmentation with individual spots of wild-type dark pigment against a lighter pigmented background in the last two abdominal segments. This variegated phenotype is suppressed if the flies are also carrying lawcp1; the areas of lighter pigmentation increase at the expense of darkly pigmented regions so that the phenotype is closer to y2 rather than y2 ; mod(mdg4)ul flies.
The arista-to-leg transformation seen in lawcp1 flies is reduced in frequency by 75% if they are also carrying lawct6.5. lawct6.5 also rescues the lethality of lawcp1. The ability of lawcp1 to enhance the cut wing phenotype of ctn is partially suppressed by lawct6.5; there is a 44% in the frequency of lawcp1 ctn flies with very cut wings if they are also carrying lawct6.5.