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General Information
Symbol
Dmel\lz77a7
Species
D. melanogaster
Name
FlyBase ID
FBal0035197
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
lzmr1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Linked to:
mr15-mr13 restriction fragment
Comment:

A deletion which includes the eye-specific enhancer. 1398bp deletion within intron II.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of 1398bp in the intronic region between exons II and III.

Deletion of the eye-specific enhancer in lz intron 2, between nucleotides 9585 and 10983 of accession number AJ217651.

1398bp deletion within intron II (the lesion is identical to that in lz50e).

Mutation of cistron A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In lz77a7 mutant third instar eye discs, R7 cells are not recruited to the ommatidia.

lz77a7 adults have a severe mutant eye phenotype. Ommatidia have too few cells or extra cells. Ectopic cell death is seen in third larval instar eye discs, between rows 7 and 12 posterior to the morphogenetic furrow.

R7 development is incomplete.

Eye colour: red. Eyes of mutant flies are shiny compared to controls. The ocelli appear reasonably normal under low power SEM. The eyes have corneal nipples which look much like those of control flies under high power SEM except with more irregularities.

Mutant flies show disruption of the organised ommatidial lattice, resulting in smooth eyes.

Rough eye phenotype: facets with multiple R7-like cells. 10% ommatidia have abnormal numbers of cells. The fenestrated membrane at the base of the retina is faulty; the holes through which the photoreceptor axons pass are enlarged and irregularly spaced. The sheer size of these holes allows entire clusters of photoreceptor cells to form an abnormal layer that displaces the first optic ganglion of the brain. Transheterozygotes with lzgal4 exhibit severely roughened eyes.

Homozygotes have a severe rough eye phenotype. Lenses are fused or missing, and some lenses are ruptured. Bristles of the hair nerve group are missing. There is a total lack of ommatidial structure. The eyes have mottled pigmentation and black pock marks are visible on the surface of the eye. Defects in the structure of pigment cells are seen and the number of photoreceptor cells per ommatidium is abnormal. Failure of the fenestrated membrane is apparent, with holes allowing photoreceptor neurons to intermingle with interneurons of the lamina. The retina is smaller than normal. lz1/lz77a7 and lz77a7/lzg females show disruption of the ommatidia and black pock marking confined to the anterior portion of the eye.

The number of large and small basiconic sensilla on the antennal funiculus is greatly reduced in hemizygous males, and the number of trichoid sensilla on the antennal funiculus is increased. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the coeloconic and trichoid sensilla on the antennal funiculus is increased and the density of the basiconic sensilla on the antennal funiculus is decreased compared to wild-type.

female fertile

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

lz77a7 has visible phenotype, non-suppressible by BacA\p35GMR.PH

Phenotype Manifest In
Enhanced by
Statement
Reference

lz77a7 has phenotype, enhanceable by zv77h

Suppressed by
Statement
Reference

lz77a7 has eye disc phenotype, suppressible by BacA\p35GMR.PH

NOT suppressed by
Statement
Reference

lz77a7 has eye phenotype, non-suppressible by BacA\p35GMR.PH

Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

No recruitment of R7 precursor cells is observed when ttk1e11 mutant cells are generated in a lz77a7 background.

Cell death is blocked in lz77a7 eye discs that are also expressing BacA\p35GMR.PH, but the lz77a7 mutant eye phenotype persists in these double mutant animals.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (1)
Stocks (2)
Notes on Origin
Discoverer

M.M. Green.

Comments
Comments

Does not revert to wild-type under dysgenic conditions. lz77a7 maps to the spectacle sublocus of lz.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (16)