FlyBase Allele Report: Dmel\pnt[1230]

General Information

Symbol

Dmel\pnt¹²³⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0035441

Feature type

allele

Associated gene

Dmel\pnt

Associated Insertion(s)

Carried in Construct

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Flores et al., 2000, Brunner et al., 1994)

Mutagen

Delta2-3 transposase

(Scholz et al., 1993)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

pnt¹²⁷⁷

(Scholz et al., 1993)

Cytology

Nature of the lesion

Statement

Reference

Small deletion that removes 5' flanking sequences and most of exon 1.

(Brunner et al., 1994)

Deletion from within the P-element that extends distally.

(Scholz et al., 1993)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

abnormal planar polarity (with pnt¹²⁷⁷)

(Weber et al., 2008)

abnormal planar polarity (with pnt^Δ88)

(Weber et al., 2008)

lethal - all die before end of larval stage | recessive

(Brunner et al., 1994, Scholz et al., 1993)

some die during larval stage | recessive

(Brunner et al., 1994, Scholz et al., 1993)

Phenotype Manifest In

Detailed Description

Statement

Reference

pnt¹²⁷⁷/pnt¹²³⁰ eye discs show polarity defects (10% of ommatidial clusters are inverted and 9% are symmetrical).

pnt¹²³⁰/pnt^Δ88 eye discs show chirality defects in 26.4% of ommatidial clusters.

(Weber et al., 2008)

Homozygous wing discs have a reduced pouch size compared to wild type.

(Nagaraj et al., 1999)

Homozygous clones in the eye lack R7 and frequently R1 and R6 cells in most ommatidia.

(Brunner et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

pnt[+]/pnt¹²³⁰ is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

pnt[+]/pnt¹²³⁰ is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

pnt¹²³⁰ is a suppressor of phenotype of Jra^Asp.hs.sev

(Treier et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

pnt^Δ88/pnt¹²⁷⁷ or pnt¹²³⁰/pnt¹²⁷⁷ completely suppresses the ectopic R7 rough eye phenotype of Jra^Asp.hs.sev.

(Treier et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Allelic series of pnt allele that affect the P2 transcript: pnt¹²⁷⁷ < pnt¹²⁰² < pnt¹²⁰⁸ < pnt¹²³⁰ <= pnt^T9 < pnt^T5.

(Scholz et al., 1993)

P2-specific mutation.

(Brunner et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

pnt¹²³⁰

(Paul et al., 2013, Weber et al., 2008, Oishi et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close