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General Information
Symbol
Dmel\aosrlt
Species
D. melanogaster
Name
FlyBase ID
FBal0035517
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
argosrlt, rlt1
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Contains a truncated P-element in the 5' UTR of argos within the proposed transcriptional start at bp 55.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Many argosrlt ommatidia mis-rotate; the variance (s.d.) in degree of rotation is greater than in wild type in adult eyes and the mean angle of orientation of the ommatidia is only 77.84[o] (compared to 90[o] in wild type).

    Homozygotes, argosrlt/argosΔ7 or argosrlt/Df(3L)st7P animals exhibit a ommatidial rotation phenotype. Clusters are seen that are both over and under-rotated with respect to their neighbours and developmental stage. Mutant animals do not exhibit any photoreceptor R3/R4 cell fate defects.

    About 12% of ommatidia in homozygous argosrlt animals exhibit extra R cells. Of those that ommatidia that remain about 49% exhibit misrotations, about 6% exhibit achirality, and about 1% exhibit the wrong chirality. About 11% of ommatidia in argosΔ7/argosrlt animals exhibit extra R cells. Of those that ommatidia that remain about 52% exhibit misrotations, about 1% exhibit achirality, and about 1% exhibit the wrong chirality. About 16% of ommatidia in argos5F4/argosrlt animals exhibit extra R cells. Of those that ommatidia that remain about 53% exhibit misrotations, about 2% exhibit achirality, and about 0.3% exhibit the wrong chirality.

    The addition of argosrlt/+ enhances the eye cell polarity phenotype seen in fz19/fz20 animals.

    Photoreceptor orientation is abnormal. The majority of ommatidia have the normal number of photoreceptors, in normal trapezoidal configuration, though 17% of ommatidia have an extra photoreceptor cell. But 47% of photoreceptor clusters actually rotate more than 90o. nmo mutants are epistatic to argosrlt with respect to ommatidial precluster orientation.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressed by
    Enhancer of
    Statement
    Reference
    NOT Enhancer of
    Statement
    Reference

    argos[+]/aosrlt is a non-enhancer of visible phenotype of Scer\GAL4en-e16E, kermitGS2053

    Suppressor of
    Statement
    Reference
    NOT Suppressor of
    Statement
    Reference

    argos[+]/aosrlt is a non-suppressor of visible phenotype of Scer\GAL4en-e16E, kermitGS2053

    Phenotype Manifest In
    Suppressed by
    Statement
    Reference

    aosrlt has ommatidium phenotype, suppressible | partially by nmoP1

    aosrlt has ommatidium phenotype, suppressible | partially by pntΔ88

    aosrlt has ommatidium phenotype, suppressible | partially by Egfrt1

    Enhancer of
    Statement
    Reference

    aosrlt is an enhancer of ommatidium phenotype of fz20/fz19

    NOT Enhancer of
    Statement
    Reference

    argos[+]/aosrlt is a non-enhancer of wing hair phenotype of Scer\GAL4en-e16E, kermitGS2053

    Suppressor of
    Statement
    Reference

    argos[+]/aosrlt is a suppressor | partially of eye phenotype of HScer\UAS.cMa/HUAS.cMa, Scer\GAL4GMR.PU

    aosrlt is a suppressor of ommatidium phenotype of Ras64BV14.Act5C

    aosrlt is a suppressor of ommatidium phenotype of Rac1V12.hs.sev

    NOT Suppressor of
    Statement
    Reference

    argos[+]/aosrlt is a non-suppressor of wing hair phenotype of Scer\GAL4en-e16E, kermitGS2053

    argos[+]/aosrlt is a non-suppressor of ommatidium phenotype of Scer\GAL4hs.2sev, nmoUAS.cUa

    aosrlt is a non-suppressor of ommatidium phenotype of ecspok

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The small-eye phenotype observed in animals expressing HScer\UAS.cMa in the eye under the control of Scer\GAL4GMR.PU is partially suppressed in a argosrlt/+ mutant background.

    The ommatidial rotation defects observed in ecspok hemizygous adult eyes are not suppressed by argosrlt/+.

    S48-5/argosrlt mutants show 3.74%+-1.99 misrotated ommatidia compared to 9.55%+-1.43 seen in S48-5 mutants alone.

    Heterozygotes suppress the ommatidial polarity defects seen in Ras64BV14.Act5C.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    References (17)