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General Information
Symbol
Dmel\rux8
Species
D. melanogaster
Name
FlyBase ID
FBal0035525
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

11bp deletion, predicted to cause a frameshift after amino acid 78 and truncation of the protein after the addition of 7 novel amino acids.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

11bp deletion, predicted to cause a frameshift after amino acid 78 and truncation of the protein after the addition of seven out-of-frame amino acids. Only the N-terminal 25% of the protein is predicted to remain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

rux8 mutant males show normal spermatocyte fusome morphology.

All cells within the morphogenetic furrow ectopically enter S phase.

Entry in the S phase is precocious, all cells reenter the cell cycle. Male germ cells progress through meiosis I and meiosis II normally but then undergo an ectopic round of nuclear division.

Ectopic S phase entry in the morphogenetic furrow. Neither a CycE deficiency or a strong point mutation dominantly suppresses the S phase phenotype.

No effect on the faf eye phenotype.

Eyes are rough, viability reduced to 10% with respect to wild type. Photoreceptor clusters form in rux8 with the same frequency and spacing as wild type. However, the organization of cells within the clusters is usually disrupted. The R8 cell number is often abnormal, and numbers of R1, R3, R4 and R6 are reduced.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

rux8 has male sterile phenotype, suppressible by twe1/twe[+]

NOT suppressed by
Statement
Reference

rux8 has male sterile phenotype, non-suppressible by stgAR2/stg[+]

rux8 has male sterile phenotype, non-suppressible by stgRXT13/stg[+]

Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

rux8 has phenotype, suppressible by CycAS(rux)3B

rux8 has phenotype, suppressible by Rca1S(rux)2A

rux8 has eye phenotype, suppressible by stgAR2/stg[+]

rux8 has eye phenotype, suppressible by stgRXT13/stg[+]

NOT suppressed by
Statement
Reference

rux8 has eye phenotype, non-suppressible by twe1/twe[+]

Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Dominantly suppresses the rough eye phenotype of CycEJP homozygotes. One copy of rux8 has no effect on the reduction in the number of cells entering S phase posterior to the morphogenetic furrow seen in CycEJP homozygotes.

Mutations in Rca1 and CycA rescue the sterility.

Flies carrying rux8 in a heterozygous stg background show partial rescue of the rough-eye phenotype, but not the male sterility, at 18oC. Removing one copy of twe rescues the sterility, but not the rough eye phenotype, of rux8.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)