Allele Dmel\rux^+t6.0

General Information
Symbol	Dmel\rux^+t6.0	Species	D. melanogaster
Name		FlyBase ID	FBal0035527
Feature type	allele	Associated gene	Dmel\rux

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - genomic fragment
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - genomic fragment (Thomas et al., 1994, Secombe et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References rescue fragment X:5,926,611..5,932,159 evidence=experimental linked_to=StuI-EcoRI_rfrag (Thomas et al., 1994)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: 6.0kb StuI-EcoRI genomic fragment including rux transcription unit. (Gonczy et al., 1994) 6.0kb EcoRI genomic fragment including rux transcription unit. (Thomas et al., 1994)
Carried in construct	P{rux} (Thomas et al., 1994, Secombe et al., 1998, Tanaka-Matakatsu et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	wild-type (Thomas et al., 1994)
Phenotype Manifest In
	cyst cell (Gonczy et al., 1994) onion stage spermatid (Gonczy et al., 1994)
Detailed Description
	Statement Reference Male germ cells with excess rux function execute only one division at meiosis resulting in cysts of 32, rather than 64, germ cells. The division that does occur is a meiosis I rather than a meiosis II division. (Gonczy et al., 1994)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference rux^+t6.0 is an enhancer of visible \| recessive phenotype of CycE^JP (Secombe et al., 1998)
Phenotype Manifest In
Enhancer of
Statement Reference rux^+t6.0 is an enhancer of eye phenotype of CycE^JP (Secombe et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference Enhances the rough eye phenotype of CycE^JP homozygotes. One copy of rux^+t6.0 has no effect on the reduction in the number of cells entering S phase posterior to the morphogenetic furrow seen in CycE^JP homozygotes. (Secombe et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	rux^+t6.0 rescues rux³ (Thomas et al., 1994) rux^+t6.0 rescues rux⁴ (Thomas et al., 1994) rux^+t6.0 rescues rux⁸ (Thomas et al., 1994)
Comments	Rescues the rough-eye phenotype of rux³, rux⁴ and rux⁸ and the sterility of rux⁸. (Thomas et al., 1994)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	rux^+t6.0
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Tanaka-Matakatsu et al., 2007, Dev. Biol. 309(2): 222--235 Mutation of the Apcl homologue shattered disrupts normal eye development by disrupting G1 cell cycle arrest and progression through mitosis. [FBrf0201230] Secombe et al., 1998, Genetics 149(4): 1867--1882 Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development. [FBrf0103367] Gonczy et al., 1994, Cell 77(7): 1015--1025 roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis. [FBrf0073190] Thomas et al., 1994, Cell 77(7): 1003--1014 Cell cycle progression in the developing Drosophila eye: roughex encodes a novel protein required for the establishment of G1. [FBrf0074608]

Allele Dmel\rux+t6.0

Allele Dmel\rux^+t6.0