FB2025_01 , released February 20, 2025
Allele: Dmel\sev::tor13D.hs
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General Information
Symbol
Dmel\sev::tor13D.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0035594
Feature type
allele
Associated gene
sev::tor
Associated Insertion(s)
Carried in Construct
P{hsp-torso4021-sev}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Lai et al., 1995, Dickson et al., 1992)
Progenitor genotype
tor13D
(Dickson et al., 1992)
Carried in construct
P{hsp-torso4021-sev}
Cytology
Description

The extracellular domain of tor13D is fused to the intracellular region of sev. The expression of this chimera is driven by an Hsp70 promoter.

(Lai et al., 1995)

The tor region contains same amino acid replacement as in tor13D gain of function allele. Expression is under the influence of an Hsp70 promoter.

(Dickson et al., 1992)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
sev::tor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A heat pulse causes different responses in different ommatidial precursors, indicating that cells can only respond to sev activity during a brief period. R7 cells are rescued only in a narrow region.

      (Dickson et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Used to study effects of constitutive activation of sev using tor sequences from gain of function tor alleles.

      (Dickson et al., 1992)

      Immunoprecipitation of protein lysates from flies expressing sev::tor13D.hs, indicates that Shc is not associated with sev::tor13D.hs protein in vivo.

      (Lai et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sev::tor13D.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (3)