Allele Dmel\sli^E-158

General Information
Symbol	Dmel\sli^E-158	Species	D. melanogaster
Name		FlyBase ID	FBal0035623
Feature type	allele	Associated gene	Dmel\sli
Also Known As	sli^E158, slit^E158

Map ( GBrowse )	Untitled Document
Allele class	loss of function allele, hypomorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Battye et al., 1999) loss of function allele (Battye et al., 2001)
Mutagen	P-element activity (Nambu et al., 1990, Rothberg et al., 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2R:11,778,529..11,778,529 (Nambu et al., 1990, Kidd et al., 1999, Rothberg et al., 1990)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P-element insert 500bp 5' to the start of translation. (Nambu et al., 1990) P{lArB} insertion 105bp upstream of the coding region and transcription initiation sequence. (Rothberg et al., 1990)
Caused by insertion	P{lArB}sli^E-158 (Nambu et al., 1990, Kidd et al., 1999, Rothberg et al., 1990)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Battye et al., 2001, Nambu et al., 1990) neuroanatomy defective (Bhat, 2005) neuroanatomy defective (with sli^k04807b) (Tayler et al., 2004)
Phenotype Manifest In
	eye photoreceptor cell & axon (with sli^k04807b) (Tayler et al., 2004) lamina anlage (with sli^k04807b) (Tayler et al., 2004) longitudinal connective (Bhat, 2005) presumptive embryonic/larval central nervous system (Kidd et al., 1999) ventral nerve cord (Battye et al., 2001)
Detailed Description
	Statement Reference Medial longitudinal tracts are seen to cross the midline in 14 hour mutant embryos. (Bhat, 2005) sli^k04807b/sli^E-158 third instar larvae show defects in photoreceptor axon targeting, with gaps in the lamina and increased numbers of axons entering the medulla. (Tayler et al., 2004) 3.1% of expected mutant embryos hatch as first instar larvae. The latest observed stage of mutants is pupa. Nerve cord length is 82% of embryo length. Midline guidance failure of repellence phenotype, evidenced by midline crossing, is mild. (Battye et al., 2001) Embryos show a partial midline collapse of the central nervous system. (Kidd et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference sli^E-158 has neuroanatomy defective phenotype, non-enhanceable by fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu (Bhat, 2005)
Phenotype Manifest In
Enhanced by
Statement Reference sli^E-158 has longitudinal connective phenotype, enhanceable by robo[+]/robo¹ (Battye et al., 1999) sli^E-158 has ventral nerve cord phenotype, enhanceable by robo[+]/robo¹ (Battye et al., 2001)
NOT Enhanced by
Statement Reference sli^E-158 has longitudinal connective phenotype, non-enhanceable by fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu (Bhat, 2005)
Enhancer of
Statement Reference sli[+]/sli^E-158 is an enhancer of longitudinal connective phenotype of robo¹ (Battye et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference The longitudinal tracts of embryos expressing NetB^Scer\UAS.cHa under the control of Scer\GAL4^unspecified in a sli^E-158 background appear similar to those seen in strong loss-of-function sli mutant embryos. Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^elav.PLu does not enhance the sli^E-158 longitudinal tract phenotype. (Bhat, 2005) Percentage of segments with midline crossovers in robo¹/sli^E-158 transheterozygotes is 35%. (Battye et al., 2001) Embryos heterozygous for both robo¹ and sli^E-158 show deviation of longitudinal fascicles towards the midline in 32% of segments. (Battye et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	E158 (Rothberg et al., 1990) sli¹⁵⁸ (Battye et al., 1999) sli^E158 (Bhat, 2005, Tayler et al., 2004) sli^E-158 slit^E158 (Parsons et al., 2003, Battye et al., 2001) slit^E-158 (Kidd et al., 1999) unnamed (Nambu et al., 1990)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Bhat, 2005, Genetics 170(1): 149--159 Slit-roundabout signaling neutralizes Netrin-Frazzled-mediated attractant cue to specify the lateral positioning of longitudinal axon pathways. [FBrf0187630] Tayler et al., 2004, Development 131(23): 5935--5945 Compartmentalization of visual centers in the Drosophila brain requires Slit and Robo proteins. [FBrf0180181] Parsons et al., 2003, Dev. Biol. 264(2): 363--375 roundabout gene family functions during sensory axon guidance in the Drosophila embryo are mediated by both Slit-dependent and Slit-independent mechanisms. [FBrf0167462] Battye et al., 2001, J. Neurosci. 21(12): 4290--4298 Repellent signaling by slit requires the leucine-rich repeats. [FBrf0136993] Battye et al., 1999, Development 126(11): 2475--2481 Axon repulsion from the midline of the Drosophila CNS requires slit function. [FBrf0108520] Kidd et al., 1999, Cell 96(6): 785--794 Slit is the midline repellent for the robo receptor in Drosophila. [FBrf0107807] Nambu et al., 1990, Cell 63: 63--75 The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells. [FBrf0051386] Rothberg et al., 1990, Genes Dev. 4: 2169--2187 slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. [FBrf0051847]

Allele Dmel\sliE-158

Allele Dmel\sli^E-158