sliE-158 homozygous embryos exhibit severe axon guidance defects in the longitudinal connective from 14h post-fertilization onwards, as compared to controls.
Medial longitudinal tracts are seen to cross the midline in 14 hour mutant embryos.
slik04807b/sliE-158 third instar larvae show defects in photoreceptor axon targeting, with gaps in the lamina and increased numbers of axons entering the medulla.
3.1% of expected mutant embryos hatch as first instar larvae. The latest observed stage of mutants is pupa. Nerve cord length is 82% of embryo length. Midline guidance failure of repellence phenotype, evidenced by midline crossing, is mild.
Embryos show a partial midline collapse of the central nervous system.