Allele Dmel\spz^D1-RPQ

General Information
Symbol	Dmel\spz^D1-RPQ	Species	D. melanogaster
Name		FlyBase ID	FBal0035690
Feature type	allele	Associated gene	Dmel\spz
Also Known As	spz^D1RPQ

Allele class	loss of function allele
Mutagen	PM hybrid dysgenesis
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Morisato and Anderson, 1994)
Mutagen	PM hybrid dysgenesis (Morisato and Anderson, 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	spz^D1 (Morisato and Anderson, 1994)
Nature of the lesion	Statement Reference Break maps to a 0.8kb XhoI-BglII fragment in the spz region. (Morisato and Anderson, 1994)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| maternal effect \| recessive (Morisato and Anderson, 1994)
Phenotype Manifest In
	embryonic/first instar larval cuticle \| maternal effect \| ventral (Morisato and Anderson, 1994) embryonic/larval somatic muscle (Halfon and Keshishian, 1998)
Detailed Description
	Statement Reference Homozygous and spz^D1-RPQ/spz⁴ larvae have significantly higher levels of muscle defects than wild-type larvae. (Halfon and Keshishian, 1998) Affected embryos are dorsalized. (Morisato and Anderson, 1994) Mutant embryos respond to injected purified polarizing activity (spz), but lack polarizing activity themselves. (Schneider et al., 1994)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference spz^D1-RPQ/Df(3R)Tl-D is a suppressor of embryonic/first instar larval cuticle \| maternal effect phenotype of Spn27A¹/Df(2L)BSC7 (Hashimoto et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference The ventralized phenotype that causes the failure of cuticle differentiation in embryos from Spn27A¹/Df(2L)BSC7 mothers is abolished when mothers also have the mutant genotype spz^D1-RPQ/Df(3R)Tl-D. Such embryos have a dorsalized phenotype that is indistinguishable from those produced by single mutant spz^D1-RPQ/Df(3R)Tl-D mothers. (Hashimoto et al., 2003) Perivitelline fluid from embryos laid by spz^D1-RPQ/Df(3R)Bd females does not show axis-inducing activity when injected into the perivitelline space of embryos derived from pip¹/pip² females. (Chang and Morisato, 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	No P element detected at spz. (Morisato and Anderson, 1994)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	spz^D1RPQ (Halfon and Keshishian, 1998, Schneider et al., 1994) spz^D1-RPQ spz^RPQ (Morisato, 2001)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Hashimoto et al., 2003, Dev. Cell 5(6): 945--950 Spatial regulation of developmental signaling by a serpin. [FBrf0167485] Chang and Morisato, 2002, Development 129(24): 5635--5645 Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo. [FBrf0151943] Morisato, 2001, Development 128(12): 2309--2319 Spatzle regulates the shape of the Dorsal gradient in the Drosophila embryo. [FBrf0137224] Halfon and Keshishian, 1998, Dev. Biol. 199(1): 164--174 The Toll pathway is required in the epidermis for muscle development in the Drosophila embryo. [FBrf0103273] Winans and Hashimoto, 1995, Mol. Biol. Cell 6(5): 587--596 Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein. [FBrf0082785] Morisato and Anderson, 1994, Cell 76(4): 677--688 The spatzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo. [FBrf0068603] Schneider et al., 1994, Development 120(5): 1243--1250 A processed form of the Spatzle protein defines dorsal-ventral polarity in the Drosophila embryo. [FBrf0074384]

Allele Dmel\spzD1-RPQ

Allele Dmel\spz^D1-RPQ