FlyBase Allele Report: Dmel\sqd[ix50]

General Information

Symbol

Dmel\sqd^ix50

Species

D. melanogaster

Name

FlyBase ID

FBal0035702

Feature type

allele

Associated gene

Dmel\sqd

Associated Insertion(s)

Carried in Construct

Allele class

Mutagen

jumpstarter activity

Nature of the Allele

Allele class

Mutagen

jumpstarter activity

(Kelley, 1993)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

sqd¹

(Kelley, 1993)

Cytology

Nature of the lesion

Statement

Reference

Imprecise excision of P-element causing a deletion of approximately 2kb of flanking genomic DNA extending to the 5' most exon of sqd.

(Kelley, 1993)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

female sterile (with sqd¹)

(Kelley, 1993)

lethal

(Kelley, 1993)

lethal (with Df(3R)urd)

(Steinhauer and Kalderon, 2005)

lethal | recessive

(Peng and Mount, 1995)

partially lethal - majority die (with sqd^j4B4)

(Steinhauer and Kalderon, 2005)

Phenotype Manifest In

oocyte (with sqd^j4B4)

(Steinhauer and Kalderon, 2005)

Detailed Description

Statement

Reference

sqd^j4B4/sqd^ix50 escaper females produce oocytes with an AP polarity defect at a 93% penetrance.

(Steinhauer and Kalderon, 2005)

Lethal in combination with Df(3R)urd. 11% of sqd^ix50/Df(3R)urd flies carrying sqd^S survive. 19% of sqd^ix50/Df(3R)urd flies carrying sqd^B survive.

(Norvell et al., 1999)

Hemizygotes are lethal. Heterozygotes in combination with sqd¹ are female sterile.

(Kelley, 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

sqd[+]/sqd^ix50 is an enhancer of egg phenotype of Imp^UAS.cGa, Scer\GAL4^{VP16.mat.αTub67C}

(Geng and MacDonald, 2007)

sqd[+]/sqd^ix50 is an enhancer of egg chorion phenotype of Imp^UAS.cGa, Scer\GAL4^{VP16.mat.αTub67C}

(Geng and MacDonald, 2007)

Additional Comments

Genetic Interactions

Statement

Reference

A sqd^ix50 heterozygous background enhances the dorsalised phenotypes observed when Imp^Scer\UAS.cGa is expressed under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} (on the second). Only 15% of eggshells are phenotypically normal, with 27% weakly dorsalised and 58% strongly dorsalised.

(Geng and MacDonald, 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

sqd^j4B4/sqd^ix50 is rescued by sqd^S

(Steinhauer and Kalderon, 2005)

Partially rescued by

Df(3R)urd/sqd^ix50 is partially rescued by sqd^S

(Norvell et al., 1999)

Df(3R)urd/sqd^ix50 is partially rescued by sqd^B

(Norvell et al., 1999)

Not rescued by

Df(3R)urd/sqd^ix50 is not rescued by sqd^A

(Norvell et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Deletion may extend into rin.

(Kelley, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sqd^IX50

(Norvell et al., 1999)

sqd^ix50

(Geng and MacDonald, 2007)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close