Allele Dmel\su(Hw)^Δ100

General Information
Symbol	Dmel\su(Hw)^Δ100	Species	D. melanogaster
Name		FlyBase ID	FBal0035724
Feature type	allele	Associated gene	Dmel\su(Hw)

Allele class
Mutagen	in vitro construct - deletion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Harrison et al., 1993)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	su(Hw)^+t5.2 (Harrison et al., 1993)
Nature of the lesion	Statement Reference Deletion of the amino terminal domain of the su(Hw) protein. (Georgiev and Kozycina, 1996) Deletion of the large acidic domain in the amino terminal region. (Gerasimova et al., 1995) In frame deletion of the 48 amino acids that constitute the amino terminal acidic domain. (Smith and Corces, 1995) Construct: In frame deletion of the amino terminal acidic domain. (Harrison et al., 1993)
Carried in construct	P{su(Hw)^Δ100} (Harrison et al., 1993, Golovnin et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (Harrison et al., 1993)
Phenotype Manifest In

Detailed Description
	Statement Reference Rescue the phenotypic suppression of y² associated with su(Hw)^V allele. (Harrison et al., 1993)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference su(Hw)^Δ100 is a suppressor of visible phenotype of sc^me (Golovnin et al., 1999)
Phenotype Manifest In
Suppressor of
Statement Reference su(Hw)^Δ100 is a suppressor of phenotype of mod(mdg4)^ul (Georgiev and Kozycina, 1996) su(Hw)^Δ100 is a suppressor of phenotype of y² (Gerasimova et al., 1995)
Additional Comments
Genetic Interactions
Statement Reference The sc^me bristle phenotype is slightly suppressed by su(Hw)^Δ100. (Golovnin et al., 1999) Does not suppress the y² phenotype in homozygotes. In combination with mod(mdg4)^ul causes strong suppression of the y mutant phenotype in the body and wings and partial suppression in the bristles. In combination with y²/y^59b and mod(mdg4)^ul pigmentation of the body and wings is wild type. In combination with mod(mdg4)^ul, su(Hw)^Δ100 completely suppresses the ac^Hw-1 phenotype. (Georgiev and Kozycina, 1996)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	su(Hw)^Δ100 su(Hw)^ΔNTAD (Ghosh et al., 2001)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Golovnin et al., 2005, Genetics 170(3): 1133--1142 Drosophila Su(Hw) histdator can stimulate transcription of a weakened yellow promoter over a distance. [FBrf0190724] Ghosh et al., 2001, EMBO J. 20(10): 2518--2527 Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function. [FBrf0136690] Golovnin et al., 1999, Mol. Cell. Biol. 19(5): 3443--3456 The su(Hw) insulator can disrupt enhancer-promoter interactions when located more than 20 kilobases away from the Drosophila achaete-scute complex. [FBrf0108187] Gdula and Corces, 1997, Genetics 145(1): 153--161 Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations. [FBrf0091383] Georgiev and Kozycina, 1996, Genetics 142(2): 425--436 Interaction between mutations in the suppressor of Hairy wing and modifier of mgd4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations. [FBrf0086415] Gerasimova et al., 1995, Cell 82(4): 587--597 A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. [FBrf0083144] Smith and Corces, 1995, Genetics 139(1): 215--228 The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon. [FBrf0079429] Harrison et al., 1993, Genes Dev. 7(10): 1966--1978 A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function. [FBrf0064493]

Allele Dmel\su(Hw)Δ100

Allele Dmel\su(Hw)^Δ100