Allele Dmel\su(Hw)^E8

General Information
Symbol	Dmel\su(Hw)^E8	Species	D. melanogaster
Name		FlyBase ID	FBal0035728
Feature type	allele	Associated gene	Dmel\su(Hw)

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Harrison et al., 1993, Smith and Corces, 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The first His residue of zinc finger 7 is changed to Tyr. (Kim et al., 1996) Nucleotide substitution: C?T. Amino acid replacement: H?Y. Mutation is in the seventh zinc finger. (Smith and Corces, 1995) Nucleotide substitution: C2109T. Amino acid replacement: H?Y. (Harrison et al., 1993)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (Harrison et al., 1993)
Phenotype Manifest In

Detailed Description
	Statement Reference su(Hw)^E8/+ completely suppresses the inhibitory effect of mod(mdg4)^ul on the expression of y in bristles. Completely suppresses the sc^D1 mutant phenotype. (Georgiev and Kozycina, 1996)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference su(Hw)⁷/su(Hw)^E8, w^BR.BR has eye color defective phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.BR has eye color defective phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.BR has eye color defective phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has body color defective phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has body color defective phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has body color defective phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has eye color defective phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has eye color defective phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has eye color defective phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has body color defective phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has body color defective phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has body color defective phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001)
NOT Enhanced by
Statement Reference su(Hw)⁷/su(Hw)^E8, w^BR.BR has eye color defective phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.BR has eye color defective phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has body color defective phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has body color defective phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has eye color defective phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has eye color defective phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has body color defective phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has body color defective phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001)
Suppressed by
Statement Reference esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)^V/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)^V/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)^V/su(Hw)^E8, w^BR.E.BR has eye color defective phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001)
Phenotype Manifest In
Enhanced by
Statement Reference su(Hw)⁷/su(Hw)^E8, w^BR.BR has pigment cell phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.BR has pigment cell phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.BR has pigment cell phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)⁷/su(Hw)^E8 (Roseman et al., 2001, Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has pigment cell phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has pigment cell phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has pigment cell phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001)
NOT Enhanced by
Statement Reference su(Hw)⁷/su(Hw)^E8, w^BR.BR has pigment cell phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.BR has pigment cell phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has pigment cell phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.BR has pigment cell phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001) su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by Scm^{hs.ΔSPM.T:ZnF-su(Hw),T:Zzzz\FLAG} (Roseman et al., 2001)
Suppressed by
Statement Reference esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) esc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)^V/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)^V/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)⁷/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001) Scm^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)^V/su(Hw)^E8, w^BR.E.BR has pigment cell phenotype, suppressible by ph-p⁴⁰⁹ (Roseman et al., 2001)
Enhancer of
Statement Reference Pc^{hs.T:ZnF-su(Hw),T:Zzzz\FLAG}, su(Hw)⁷/su(Hw)^E8 is an enhancer of adult cuticle phenotype of su(Hw)⁷/su(Hw)^E8, y^+mDint2 (Roseman et al., 2001, Roseman et al., 2001)
Suppressor of
Statement Reference su(Hw)^E8 is a suppressor of phenotype of y² (Harrison et al., 1993)
Additional Comments
Genetic Interactions
Statement Reference Strong suppression of the y² phenotype. (Harrison et al., 1993)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Severe su(Hw) allele. (Harrison et al., 1993)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	su(Hw)^E8
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Roseman et al., 2001, Genetics 158(1): 291--307 Long-range repression by multiple Polycomb Group (PcG) proteins targeted by fusion to a defined DNA-binding domain in Drosophila. [FBrf0135809] Georgiev and Kozycina, 1996, Genetics 142(2): 425--436 Interaction between mutations in the suppressor of Hairy wing and modifier of mgd4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations. [FBrf0086415] Kim et al., 1996, Mol. Cell. Biol. 16(7): 3381--3392 The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein. [FBrf0088296] Smith and Corces, 1995, Genetics 139(1): 215--228 The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon. [FBrf0079429] Harrison et al., 1993, Genes Dev. 7(10): 1966--1978 A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function. [FBrf0064493]

Allele Dmel\su(Hw)E8

Allele Dmel\su(Hw)^E8