Allele Dmel\su(Hw)^e2

General Information
Symbol	Dmel\su(Hw)^e2	Species	D. melanogaster
Name		FlyBase ID	FBal0035732
Feature type	allele	Associated gene	Dmel\su(Hw)

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Dorsett, 1993, Harrison et al., 1993)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid substitution: in the seventh zinc finger motif of the su(Hw) protein. (Georgiev and Kozycina, 1996) The second Arg residue between the two His residues of zinc finger 7 is changed to His. (Kim et al., 1996) Mutant zinc finger. (Morcillo et al., 1996) Point mutation in one of the zinc fingers. (Dorsett, 1993) Nucleotide substitution: G2116A. Amino acid replacement: R?H. Mutation occurs at the base of the seventh zinc finger. (Harrison et al., 1993)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Mild mutation. Combination with mod(mdg4)^ul leads to a complete suppression of the mutant y^- phenotype. su(Hw)^e2/+ in combination with mod(mdg4)^ul is phenotypically similar to strong alleles such as su(Hw)^V. Partially suppresses the sc^D1 mutant phenotype. Suppression is enhanced by mod(mdg4)^ul. (Georgiev and Kozycina, 1996) Weak suppression of the y² phenotype. (Harrison et al., 1993)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference ct^L32, su(Hw)^e2 has visible phenotype, enhanceable by Chi[+]/Chi^g1 (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has visible phenotype, enhanceable by Chi[+]/Chi^g96.1 (Morcillo et al., 1996) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-C160.1 (Rollins et al., 1999) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-D263.3 (Rollins et al., 1999) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-D341.1 (Rollins et al., 1999) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-E43 (Rollins et al., 1999) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-E299.1 (Rollins et al., 1999) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-E338 (Rollins et al., 1999) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Nipped-B[+]/Nipped-B^292.1 (Rollins et al., 1999) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴⁰⁷ (Rollins et al., 1999)
NOT Enhanced by
Statement Reference Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-enhanceable by Nipped-A^222.3 (Rollins et al., 1999) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-enhanceable by Nipped-A³²³ (Rollins et al., 1999)
NOT suppressed by
Statement Reference Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-suppressible by Nipped-A^222.3 (Rollins et al., 1999) Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-suppressible by Nipped-A³²³ (Rollins et al., 1999)
Suppressor of
Statement Reference su(Hw)^e2 is a suppressor of visible phenotype of ct^L32/ct⁶ (Morcillo et al., 1996)
Phenotype Manifest In
Enhanced by
Statement Reference ct^L32, su(Hw)^e2 has wing margin phenotype, enhanceable by wg[+]/wg^l-17 (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by ap^56f/ap[+] (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Chi[+]/Chi^g1 (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Chi[+]/Chi^g96.1 (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-A^C25/+ (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-C160.1 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-D263.3 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-D341.1 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-E43 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-E299.1 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-E338 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by mam^g2.1/mam[+] (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by mam^g5.0/mam[+] (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by mam^g10.2/mam[+] (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A² (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^222.3 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^226.1 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A³²³ (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^357.2 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^394.2 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴ (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B^292.1 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B^359.1 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴⁰⁷ (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by sd[+]/sd^g6 (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by T(2;3)Nipped-C138.2 (Rollins et al., 1999) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by vg[+]/vg¹ (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by vg[+]/vg^dd (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by wg[+]/wg^l-17 (Morcillo et al., 1996) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC6 (Gause et al., 2008) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC7 (Gause et al., 2008) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC39 (Gause et al., 2008) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC59 (Gause et al., 2008) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC71 (Gause et al., 2008) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC78 (Gause et al., 2008) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B^NC23/Nipped-B[+] (Gause et al., 2008) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B^NC41/Nipped-B[+] (Gause et al., 2008) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B^NC77/Nipped-B[+] (Gause et al., 2008)
NOT Enhanced by
Statement Reference ct^L32, su(Hw)^e2 has wing phenotype, non-enhanceable by RpL38^45-72 (Rollins et al., 1999)
Suppressor of
Statement Reference su(Hw)^e2 is a suppressor of phenotype of ct⁶ (Dorsett, 1993) su(Hw)^e2 is a suppressor of phenotype of Ubx^bx-34e (Morcillo et al., 1996, Dorsett, 1993) su(Hw)^e2 is a suppressor of wing phenotype of ct^L32/ct⁶ (Morcillo et al., 1996)
Other
Statement Reference ct⁶, su(Hw)^e2 has wing phenotype (Morcillo et al., 1996, Morcillo et al., 1996) ct^83h, su(Hw)^e2 has wing phenotype (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing margin phenotype (Morcillo et al., 1996) ct^L32, su(Hw)^e2 has wing phenotype (Morcillo et al., 1996) Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype (Gause et al., 2008)
Additional Comments
Genetic Interactions
Statement Reference Ubx[bx-34e], su(Hw)[e2] animals display a bithorax phenotype. (Gause et al., 2008) ct^L32, su(Hw)^e2 double mutants display approximately 0.01 wing margin nicks per fly. (Rollins et al., 1999) ct⁶; su(Hw)^e2 flies have a scalloped cut wing phenotype. (Morcillo et al., 1996) Complete suppression of Ubx^bx-34e bithorax phenotype at 29^oC when in combination with su(Hw)⁷. Heteroallelic combinations with su(Hw)² and su(Hw)⁷ completely suppress the ct⁶ wing phenotype at 29^oC. (Dorsett, 1993)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Displays about 10% of wild type gypsy DNA binding activity. (Morcillo et al., 1996) Weak su(Hw) allele. (Harrison et al., 1993)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	su(Hw)^e2 (Gause et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Gause et al., 2008, Chromosoma 117(1): 51--66 Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells. [FBrf0203143] Rollins et al., 1999, Genetics 152(2): 577--593 Nipped-B, a Drosophila homologue of chromosomal adherins, participates in activation by remote enhancers in the cut and Ultrabithorax genes. [FBrf0109032] Georgiev and Kozycina, 1996, Genetics 142(2): 425--436 Interaction between mutations in the suppressor of Hairy wing and modifier of mgd4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations. [FBrf0086415] Kim et al., 1996, Mol. Cell. Biol. 16(7): 3381--3392 The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein. [FBrf0088296] Morcillo et al., 1996, Genetics 144(3): 1143--1154 Genes regulating the remote wing margin enhancer in the Drosophila cut locus. [FBrf0090702] Dorsett, 1993, Genetics 134(4): 1135--1144 Distance-independent inactivation of an enhancer by the suppressor of Hairy-wing DNA-binding protein of Drosophila. [FBrf0058581] Harrison et al., 1993, Genes Dev. 7(10): 1966--1978 A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function. [FBrf0064493]

Allele Dmel\su(Hw)e2

Allele Dmel\su(Hw)^e2