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General Information
Symbol
Dmel\su(Hw)e2
Species
D. melanogaster
Name
FlyBase ID
FBal0035732
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G14306451A

Reported nucleotide change:

G2116A

Amino acid change:

R461H | su(Hw)-PA; R461H | su(Hw)-PB; R461H | su(Hw)-PC

Reported amino acid change:

R?H

Comment:

Reported nucleotide numbering from FBrf0048095.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid substitution: in the seventh zinc finger motif of the su(Hw) protein.

The second Arg residue between the two His residues of zinc finger 7 is changed to His.

Mutant zinc finger.

Point mutation in one of the zinc fingers.

Nucleotide substitution: G2116A. Amino acid replacement: R?H. Mutation occurs at the base of the seventh zinc finger.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mild mutation. Combination with mod(mdg4)ul leads to a complete suppression of the mutant y- phenotype. su(Hw)e2/+ in combination with mod(mdg4)ul is phenotypically similar to strong alleles such as su(Hw)V. Partially suppresses the scD1 mutant phenotype. Suppression is enhanced by mod(mdg4)ul.

Weak suppression of the y2 phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Ubxbx-34e, su(Hw)e2 has visible phenotype, enhanceable by Nipped-B[+]/Nipped-B292.1

Ubxbx-34e, su(Hw)e2 has visible phenotype, enhanceable by Nipped-B[+]/Nipped-B407

ctL32, su(Hw)e2 has visible phenotype, enhanceable by Chi[+]/Chig1

ctL32, su(Hw)e2 has visible phenotype, enhanceable by Chi[+]/Chig96.1

NOT Enhanced by
Statement
Reference

Ubxbx-34e, su(Hw)e2 has visible phenotype, non-enhanceable by Nipped-A222.3

Ubxbx-34e, su(Hw)e2 has visible phenotype, non-enhanceable by Nipped-A323

NOT suppressed by
Statement
Reference

Ubxbx-34e, su(Hw)e2 has visible phenotype, non-suppressible by Nipped-A222.3

Ubxbx-34e, su(Hw)e2 has visible phenotype, non-suppressible by Nipped-A323

Suppressor of
Statement
Reference

su(Hw)e2 is a suppressor of visible phenotype of ctL32/ct6

Phenotype Manifest In
Enhanced by
Statement
Reference

Ubxbx-34e, su(Hw)e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-BNC6

Ubxbx-34e, su(Hw)e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-BNC7

Ubxbx-34e, su(Hw)e2 has adult thorax phenotype, enhanceable by Nipped-BNC23/Nipped-B[+]

Ubxbx-34e, su(Hw)e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-BNC39

Ubxbx-34e, su(Hw)e2 has adult thorax phenotype, enhanceable by Nipped-BNC41/Nipped-B[+]

Ubxbx-34e, su(Hw)e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-BNC59

Ubxbx-34e, su(Hw)e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-BNC71

Ubxbx-34e, su(Hw)e2 has adult thorax phenotype, enhanceable by Nipped-BNC77/Nipped-B[+]

Ubxbx-34e, su(Hw)e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-BNC78

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A222.3

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A323

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Df(2R)Nipped-AC25/+

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Df(2R)Nipped-E43

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Df(2R)Nipped-E338

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A394.2

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A226.1

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A357.2

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A2

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B4

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B292.1

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B359.1

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B407

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Chi[+]/Chig1

ctL32, su(Hw)e2 has wing phenotype, enhanceable by Chi[+]/Chig96.1

ctL32, su(Hw)e2 has wing phenotype, enhanceable by wg[+]/wgl-17

ctL32, su(Hw)e2 has wing margin phenotype, enhanceable by wg[+]/wgl-17

ctL32, su(Hw)e2 has wing phenotype, enhanceable by ap56f/ap[+]

ctL32, su(Hw)e2 has wing phenotype, enhanceable by vg[+]/vg1

ctL32, su(Hw)e2 has wing phenotype, enhanceable by vg[+]/vgdd

ctL32, su(Hw)e2 has wing phenotype, enhanceable by mamg10.2/mam[+]

ctL32, su(Hw)e2 has wing phenotype, enhanceable by mamg2.1/mam[+]

ctL32, su(Hw)e2 has wing phenotype, enhanceable by mamg5.0/mam[+]

ctL32, su(Hw)e2 has wing phenotype, enhanceable by sd[+]/sdg6

NOT Enhanced by
Statement
Reference

ctL32, su(Hw)e2 has wing phenotype, non-enhanceable by RpL3845-72

Suppressor of
Statement
Reference

su(Hw)e2 is a suppressor of phenotype of Ubxbx-34e

su(Hw)e2 is a suppressor of wing phenotype of ctL32/ct6

su(Hw)e2 is a suppressor of phenotype of ct6

Other
Additional Comments
Genetic Interactions
Statement
Reference

Ubxbx-34e, su(Hw)e2 animals display a bithorax phenotype.

ctL32, su(Hw)e2 double mutants display approximately 0.01 wing margin nicks per fly.

ct6; su(Hw)e2 flies have a scalloped cut wing phenotype.

Complete suppression of Ubxbx-34e bithorax phenotype at 29oC when in combination with su(Hw)7. Heteroallelic combinations with su(Hw)2 and su(Hw)7 completely suppress the ct6 wing phenotype at 29oC.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Displays about 10% of wild type gypsy DNA binding activity.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)