Allele Dmel\ttk^69.hs

General Information
Symbol	Dmel\ttk^69.hs	Species	D. melanogaster
Name		FlyBase ID	FBal0035856
Feature type	allele	Associated gene	Dmel\ttk

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Read et al., 1992, Guo et al., 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: ttk cDNA under control of an Hsp70 promoter. (Guo et al., 1995) ttk 3.2 transcript encoding the 69kD protein is under the control of a Hsp70 promoter. (Read et al., 1992)
Carried in construct	P{hs69-ttk} (Badenhorst, 2001, Badenhorst et al., 2002, Read et al., 1992, Guo et al., 1995, Vervoort et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pupal stage \| heat sensitive (Guo et al., 1995)
Phenotype Manifest In
	chordotonal organ \| heat sensitive (Vervoort et al., 1997) extended germ band embryo \| heat sensitive (Vervoort et al., 1997) external sensory organ \| embryonic stage \| heat sensitive (Guo et al., 1995) external sensory organ \| heat sensitive (Vervoort et al., 1997) multidendritic neuron \| heat sensitive (Vervoort et al., 1997) scolopidial neuron \| embryonic stage \| heat sensitive (Guo et al., 1995)
Detailed Description
	Statement Reference Embryos heat shocked at 5-6 hours of development do not complete germ band retraction. Embryos exhibit an almost complete loss of neurons. (Vervoort et al., 1997) Overexpression of ttk at 6-5 to 8.5 hours of embryonic development causes significant reduction in the number of peripheral neurons. Scolopale cells are transformed to cap cells and external sensory organs are transformed to support cells. Overexpression in the adult results in duplicated bristles and multiple sockets. (Guo et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference ttk^69.hs is a suppressor \| partially of wing margin bristle \| ectopic phenotype of ac^Hw-49c (Badenhorst et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference The addition of ttk^69.hs/+ to ac^Hw-49c/+ animals leads to slight suppression of the ectopic wing margin bristle phenotype (80% of the bristles). (Badenhorst et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	ttk^69.hs
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Badenhorst et al., 2002, Mech. Dev. 117(1-2): 87--101 Tramtrack co-operates to prevent inappropriate neural development in Drosophila. [FBrf0152198] Badenhorst, 2001, Development 128(20): 4093--4101 Tramtrack controls glial number and identity in the Drosophila embryonic CNS. [FBrf0139635] Vervoort et al., 1997, Development 124(14): 2819--2828 Genetic basis of the formation and identity of type I and type II neurons in Drosophila embryos. [FBrf0097687] Guo et al., 1995, Neuron 14(5): 913--925 tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS. [FBrf0082058] Read et al., 1992, Mech. Dev. 38(3): 183--195 Ectopic expression of the Drosophila tramtrack gene results in multiple embryonic defects, including repression of even-skipped and fushi tarazu. [FBrf0057137]

Allele Dmel\ttk69.hs

Allele Dmel\ttk^69.hs