Allele Dmel\y^+2MC

General Information
Symbol	Dmel\y^+2MC	Species	D. melanogaster
Name		FlyBase ID	FBal0036025
Feature type	allele	Associated gene	Dmel\y

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	mitomycin C
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	mitomycin C (Georgiev et al., 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site X:249,853..249,856 (Soldatov et al., 1999, Gerasimova et al., 1995, Gause et al., 1996, Georgiev and Corces, 1995)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	y² (Georgiev et al., 1990, Georgiev and Corces, 1995, Gerasimova et al., 1995, Gause et al., 1996)
Nature of the lesion	Statement Reference Transposition of jockey and 1.8kb of the sc gene (which contains an enhancer responsible for the development of anterior notopleural bristles) from sc^D1 into the gypsy element at the y locus. Insertion into y is in opposite orientation to that of y^2#+9. (Gause et al., 1996) Deletion of all 12 su(Hw) binding sites within gypsy and jockey insertion in this region. (Georgiev and Corces, 1995) Deletion of the su(Hw) binding region within the gypsy between nucleotides 501 and 1046 concomitant with the insertion of a jockey element. (Gerasimova et al., 1995) Insert stated as cause: undefined Insertion of at least 5kb DNA into the gypsy element present in y². (Georgiev et al., 1990)
Caused by insertion	gypsy{}y² (Soldatov et al., 1999, Gerasimova et al., 1995, Gause et al., 1996, Georgiev and Corces, 1995) jockey{}y^+2MC (Soldatov et al., 1999, Gerasimova et al., 1995, Gause et al., 1996, Georgiev and Corces, 1995)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Body colour: mutant flies have wild-type pigmentation in the body and wings and in the thoracic, leg and abdominal bristles. (Soldatov et al., 1999) Pigmentation of homozygotes is normal. (Gerasimova et al., 1995) Revertant. (Georgiev et al., 1990)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference e(y)1¹, y^+2MC has body color defective phenotype (Soldatov et al., 1999)
Phenotype Manifest In
NOT Enhanced by
Statement Reference y^+2MC has phenotype, non-enhanceable by mod(mdg4)^ul (Georgiev and Corces, 1995)
Suppressed by
Statement Reference sc^+2MC, y^+2MC has anterior notopleural bristle phenotype, suppressible \| partially by e(y)2¹ (Gause et al., 1996) sc^+2MC, y^+2MC has anterior notopleural bristle phenotype, suppressible \| partially by z^op6 (Gause et al., 1996)
NOT suppressed by
Statement Reference sc^+2MC, y^+2MC has anterior notopleural bristle phenotype, non-suppressible by e(y)1¹ (Gause et al., 1996) sc^+2MC, y^+2MC has anterior notopleural bristle phenotype, non-suppressible by e(y)3⁴ (Gause et al., 1996)
Other
Statement Reference e(y)1¹, y^+2MC has adult abdomen & macrochaeta phenotype (Soldatov et al., 1999) e(y)1¹, y^+2MC has adult thorax & macrochaeta phenotype (Soldatov et al., 1999) e(y)1¹, y^+2MC has leg & external sensory organ phenotype (Soldatov et al., 1999) sc^+2MC, y^+2MC has anterior notopleural bristle phenotype (Gause et al., 1996)
Additional Comments
Genetic Interactions
Statement Reference Pigmentation of the thoracic, leg and abdominal bristles is reduced in combination with e(y)1¹. (Soldatov et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Trans-inactivation by mod(mdg4)^ul. (Georgiev and Kozitsina, 1992)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	y^+2MC
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Soldatov et al., 1999, Mol. Cell. Biol. 19(5): 3769--3778 TAFII40 protein is encoded by the e(y)1 gene: biological consequences of mutations. [FBrf0108279] Gause et al., 1996, Mol. Gen. Genet. 253(3): 370--376 Phenotypic reversion of the gypsy-induced mutation sc^D1 of Drosophila melanogaster by replicative transposition of a sc enhancer to the yellow gene and by mutations in the enhancer of yellow and zeste loci. [FBrf0091060] Georgiev and Corces, 1995, Proc. Natl. Acad. Sci. U.S.A. 92(11): 5184--5188 The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog. [FBrf0082023] Gerasimova et al., 1995, Cell 82(4): 587--597 A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. [FBrf0083144] Georgiev and Kozitsina, 1992, Genetika, Moscow 28(9): 66--74 [Effect of mutations in the genes su(Hw) and mod(mdg4) on transvection between alleles of the yellow locus in Drosophila melanogaster.] [FBrf0056292] Georgiev et al., 1990, Mol. Gen. Genet. 220: 229--233 Mitomycin C induces genomic rearrangements involving transposable elements in Drosophila melanogaster. [FBrf0052593]

Allele Dmel\y+2MC

Allele Dmel\y^+2MC