Allele Dmel\zip^IIX62

General Information
Symbol	Dmel\zip^IIX62	Species	D. melanogaster
Name		FlyBase ID	FBal0036091
Feature type	allele	Associated gene	Dmel\zip

Allele class	amorphic allele - genetic evidence
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Young et al., 1993)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Deficiency breakpoint within the zip locus. (Young et al., 1993)
Caused by aberration	Df(2R)gsb (Blake et al., 1998, Young et al., 1993)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage (Young et al., 1993)
Phenotype Manifest In
	amnioserosa (with zip²) (Franke et al., 2005) dorsal closure embryo (with zip²) (Franke et al., 2005) embryonic head (Jacinto et al., 2002) embryonic head (with zip¹) (Jacinto et al., 2002) embryonic leading edge cell (Jacinto et al., 2002) embryonic leading edge cell (with zip¹) (Jacinto et al., 2002) embryonic leading edge cell (with zip²) (Franke et al., 2005) epidermis \| dorsal (Young et al., 1993) filamentous actin \| dorsal closure stage (with zip²) (Franke et al., 2005) filopodium (Jacinto et al., 2002) filopodium (with zip¹) (Jacinto et al., 2002)
Detailed Description
	Statement Reference zip²/zip^IIX62 embryos show a dorsal closure phenotype with a low penetrance. Time-lapse imaging shows that in affected embryos there is a decrease in the rate of closure at end stages and the distribution of F-actin in leading-edge cells is disorganized as closure progresses. Additionally, there is a failure in the structural integrity of the amnioserosa, leading-edge cells, and the junction between them. (Franke et al., 2005) zip¹/zip^IIX62 embryos exhibit dramatic defects in head involution. 58% of zip¹/zip^IIX62 embryos have a clear dorsal hole (i.e.- dorsal closure is incomplete). The remaining embryos complete dorsal closure, although they frequently show puckering or segment misalignments along the closed midline seam. During dorsal closure the leading edge in zip¹/zip^IIX62 embryos is very disporganized and extends a broader extent of lamellipodial and filopodial protrusions per unit length of leading edge than wild-type. (Jacinto et al., 2002) Embryos fail to complete dorsal closure as the mutant myosin fails to contribute sufficient myosin to drive dorsal closure to completion. (Young et al., 1993)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference zip^IIX62/zip[+] is an enhancer of visible phenotype of Scer\GAL4^hs.PB, tow^Scer\UAS.cCa (Chung et al., 2007)
Suppressor of
Statement Reference zip^IIX62 is a suppressor of lethal \| male phenotype of flw⁶ (Vereshchagina et al., 2004) zip^IIX62 is a suppressor of lethal \| male phenotype of flw^G0172/flw^G0172 (Vereshchagina et al., 2004)
Other
Statement Reference Df(2R)P34, zip^IIX62 has viable phenotype (Blake et al., 1998) rib¹, zip^IIX62 has viable phenotype (Blake et al., 1998, Blake et al., 1998) rib², zip^IIX62 has viable phenotype (Blake et al., 1998, Blake et al., 1998)
Phenotype Manifest In
Enhancer of
Statement Reference zip^IIX62/zip[+] is an enhancer of wing hair \| supernumerary phenotype of Scer\GAL4^hs.PB, tow^Scer\UAS.cCa (Chung et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference The multiple wing hair phenotype caused by expression of tow^Scer\UAS.cCa under the control of Scer\GAL4^hs.PB using heat shock at 24 hours after puparium formation is enhanced if the flies are also carrying one copy of zip^IIX62. (Chung et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	2528 Df(2R)gsb, cn¹ bw¹ zip^IIX62 gsb^IIX62/CyO
Kyoto	107384 y^* w^*; Df(2R)gsb, cn¹ bw¹ zip^IIX62 gsb^IIX62/SM1, sp²
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	DfII62x (Franke et al., 2005) unnamed (Blake et al., 1998) zip^IIX62 (Chung et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Chung et al., 2007, Genetics 176(2): 891--903 The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. [FBrf0202398] Franke et al., 2005, Curr. Biol. 15(24): 2208--2221 Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. [FBrf0190012] Vereshchagina et al., 2004, Mol. Biol. Cell 15(10): 4395--4405 the essential role of PP1beta in Drosophila is to regulate nonmuscle myosin. [FBrf0180501] Jacinto et al., 2002, Curr. Biol. 12(14): 1245--1250 Dynamic analysis of actin cable function during Drosophila dorsal closure. [FBrf0151835] Ohshiro et al., 2000, Nature 408(6812): 593--596 Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. [FBrf0132417] Peng et al., 2000, Nature 408(6812): 596--600 The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. [FBrf0132418] Blake et al., 1998, Dev. Biol. 203(1): 177--188 The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in Drosophila. [FBrf0105199] Young et al., 1993, Genes Dev. 7(1): 29--41 Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function. [FBrf0058526]

Allele Dmel\zipIIX62

Allele Dmel\zip^IIX62