|Feature type||allele||Associated gene||Dmel\zip|
|Also Known As||zip1.3|
|Map ( GBrowse )|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: Q?@. Nucleotide substitution: C?T.
|Phenotype Manifest In|
The salivary glands of mutant embryos are wider and shorter than normal, appearing to have bulges and bubbles in their lumens. Malpighian tubules are abnormal. Homozygous embryos have both sensory and nonsensory cuticular hairs which resemble those of wild-type embryos.
Homozygous embryos do not complete head involution. The salivary glands are enlarged, with lumens distended by bulges and bubbles. Malpighian tubules are abnormal, remaining coiled near their juncture with the hindgut rather than extending anteriorly as in the wild-type. Abnormal branching of the tubules, consisting of short dead-ends extending only the length of one or two cells, is seen. The diameter of the Malpighian tubules is similar to wild-type. The hindgut appears normal and the midgut constrictions appear slightly less pronounced than wild-type. Abnormalities in the peripheral nervous system cannot be detected.
Mutant phenotype can be rescued to adulthood by P-element mediated introduction of a genomic fragment spanning the entire transcription unit. Rescue by zip cDNA driven from a minimal Hsp70 promoter allows rescue to larvae and intermittant heat shocks allows some rescue to adulthood. During the late dorsal closure stages myosin is absent from the leading edge causing a prominent, irregularly shaped dorsal opening in the cuticle.
|Phenotype Manifest In|
Partially suppresses the salivary gland phenotype of raw1 and rib1; the salivary glands are more similar to wild type and raw1 zipmhc-c1.3 salivary glands accumulate a secreted product in their lumens (as in wild-type embryos). Partially suppresses the Malpighian tubule phenotype of raw1 and rib1.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 11 )|