Allele Dmel\zip^mhc-c1.3

General Information
Symbol	Dmel\zip^mhc-c1.3	Species	D. melanogaster
Name		FlyBase ID	FBal0036093
Feature type	allele	Associated gene	Dmel\zip
Also Known As	zip^1.3

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Young et al., 1993)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:20,879,424..20,879,424 evidence=experimental na_change=C20879424T pr_change=Q1937\|zip-PB,Q1982\|zip-PA,Q1897\|zip-PC,Q194 2\|zip-PD (Young et al., 1993, Mansfield et al., 1996)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q?@. Nucleotide substitution: C?T. (Young et al., 1993)
Cytology
Phenotypic Data
Phenotypic Class
	electrophoretic variant (Mansfield et al., 1996) lethal \| embryonic stage (Young et al., 1993) lethal \| embryonic stage \| recessive (Franke et al., 2006)
Phenotype Manifest In
	embryonic/larval midgut \| embryonic stage (Blake et al., 1998) embryonic/larval salivary gland \| embryonic stage (Blake et al., 1999, Blake et al., 1998) embryonic head (Blake et al., 1998) embryonic Malpighian tubule (Blake et al., 1998) epidermis \| dorsal (Young et al., 1993) Malpighian tubule (Blake et al., 1999) midgut constriction (Blake et al., 1998)
Detailed Description
	Statement Reference The salivary glands of mutant embryos are wider and shorter than normal, appearing to have bulges and bubbles in their lumens. Malpighian tubules are abnormal. Homozygous embryos have both sensory and nonsensory cuticular hairs which resemble those of wild-type embryos. (Blake et al., 1999) Homozygous embryos do not complete head involution. The salivary glands are enlarged, with lumens distended by bulges and bubbles. Malpighian tubules are abnormal, remaining coiled near their juncture with the hindgut rather than extending anteriorly as in the wild-type. Abnormal branching of the tubules, consisting of short dead-ends extending only the length of one or two cells, is seen. The diameter of the Malpighian tubules is similar to wild-type. The hindgut appears normal and the midgut constrictions appear slightly less pronounced than wild-type. Abnormalities in the peripheral nervous system cannot be detected. (Blake et al., 1998) Mutant phenotype can be rescued to adulthood by P-element mediated introduction of a genomic fragment spanning the entire transcription unit. Rescue by zip cDNA driven from a minimal Hsp70 promoter allows rescue to larvae and intermittant heat shocks allows some rescue to adulthood. During the late dorsal closure stages myosin is absent from the leading edge causing a prominent, irregularly shaped dorsal opening in the cuticle. (Young et al., 1993)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference Df(2R)P34, zip^mhc-c1.3 has viable phenotype (Blake et al., 1998) rib¹, zip^mhc-c1.3 has viable phenotype (Blake et al., 1998, Blake et al., 1998) rib², zip^mhc-c1.3 has viable phenotype (Blake et al., 1998, Blake et al., 1998)
Phenotype Manifest In
Suppressor of
Statement Reference zip^mhc-c1.3 is a suppressor of embryonic/larval salivary gland \| embryonic stage phenotype of raw¹ (Blake et al., 1999) zip^mhc-c1.3 is a suppressor of embryonic/larval salivary gland \| embryonic stage phenotype of rib¹ (Blake et al., 1999) zip^mhc-c1.3 is a suppressor of Malpighian tubule phenotype of raw¹ (Blake et al., 1999) zip^mhc-c1.3 is a suppressor of Malpighian tubule phenotype of rib¹ (Blake et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference Partially suppresses the salivary gland phenotype of raw¹ and rib¹; the salivary glands are more similar to wild type and raw¹ zip^mhc-c1.3 salivary glands accumulate a secreted product in their lumens (as in wild-type embryos). Partially suppresses the Malpighian tubule phenotype of raw¹ and rib¹. (Blake et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	zip^1.3 (Jack and Myette, 1999, Blake et al., 1999, Blake et al., 1998, Su et al., 1996, Franke et al., 2006, Franke et al., 2010, Monier et al., 2010) zip^mhc-c1.3
Name Synonym
Secondary FlyBase IDs

References ( 11 )
Research paper	Franke et al., 2010, Dev. Biol. 345(2): 117--132 Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis. [FBrf0211576] Monier et al., 2010, Nat. Cell Biol. 12(1): 60--65 An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos. [FBrf0209576] Franke et al., 2006, Cell Motility Cytoskel. 63(10): 604--622 Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster. [FBrf0193420] Blake et al., 1999, Dev. Genes Evol. 209(9): 555--559 ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeleton. [FBrf0111332] Jack and Myette, 1999, Dev. Genes Evol. 209(9): 546--554 Mutations that alter the morphology of the Malpighian tubules in Drosophila. [FBrf0111391] Blake et al., 1998, Dev. Biol. 203(1): 177--188 The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in Drosophila. [FBrf0105199] Mansfield et al., 1996, J. Mol. Biol. 255(1): 98--109 Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain. [FBrf0085514] Young et al., 1993, Genes Dev. 7(1): 29--41 Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function. [FBrf0058526]
Review	Skaer, 1993, Bate, Martinez Arias, 1993: 941--1012 The alimentary canal. [FBrf0064792]
Abstract	Su et al., 1996, A. Dros. Res. Conf. 37: 107 Expression of Drosophila nonmuscle myosin tail fragments in Escherichia coli: filament assembly and phosphorylation. [FBrf0085998] Mansfield et al., 1992, Mol. Biol. Cell 3(Suppl.): 45a The genomic DNA structure of the Drosophila cytoplasmic myosin heavy chain gene. [FBrf0057197]

Allele Dmel\zipmhc-c1.3

Allele Dmel\zip^mhc-c1.3