Allele Dmel\zip^mhc-c2.1

General Information
Symbol	Dmel\zip^mhc-c2.1	Species	D. melanogaster
Name		FlyBase ID	FBal0036096
Feature type	allele	Associated gene	Dmel\zip
Also Known As	zip^2.1

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Young et al., 1993)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage (Young et al., 1993) lethal \| recessive (Halsell and Kiehart, 1998) visible \| somatic clone (Franke et al., 2010)
Phenotype Manifest In
	epidermis \| dorsal (Young et al., 1993) wing \| somatic clone (Franke et al., 2010) wing vein \| somatic clone (Franke et al., 2010)
Detailed Description
	Statement Reference Homozygous clones result in wing defects including vein expansion, blisters and necrotic regions. (Franke et al., 2010) Lethality acts post-embryonically. Produces malformed phenotype when in double heterozygosis with second site zip non-complementing mutants. (Halsell and Kiehart, 1998) Embryos fail to complete dorsal closure as the mutant myosin fails to contribute sufficient myosin to drive dorsal closure to completion. (Young et al., 1993)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference Df(2R)P34, zip^mhc-c2.1 has viable phenotype (Blake et al., 1998) rib¹, zip^mhc-c2.1 has viable phenotype (Blake et al., 1998, Blake et al., 1998) rib², zip^mhc-c2.1 has viable phenotype (Blake et al., 1998, Blake et al., 1998)
Phenotype Manifest In
NOT Suppressor of
Statement Reference zip^mhc-c2.1 is a non-suppressor of embryonic/larval salivary gland \| embryonic stage phenotype of raw¹ (Blake et al., 1999) zip^mhc-c2.1 is a non-suppressor of embryonic/larval salivary gland \| embryonic stage phenotype of rib¹ (Blake et al., 1999) zip^mhc-c2.1 is a non-suppressor of Malpighian tubule phenotype of raw¹ (Blake et al., 1999) zip^mhc-c2.1 is a non-suppressor of Malpighian tubule phenotype of rib¹ (Blake et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference Does not suppress the salivary gland or Malpighian tubule phenotypes of raw¹ and rib¹. (Blake et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	zip^2.1 (Williams et al., 2001, Blake et al., 1999, Blake et al., 1998, Halsell and Kiehart, 1998, Franke et al., 2010) zip^mhc-c2.1
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Franke et al., 2010, Dev. Biol. 345(2): 117--132 Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis. [FBrf0211576] Blake et al., 1999, Dev. Genes Evol. 209(9): 555--559 ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeleton. [FBrf0111332] Blake et al., 1998, Dev. Biol. 203(1): 177--188 The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in Drosophila. [FBrf0105199] Halsell and Kiehart, 1998, Genetics 148(4): 1845--1863 Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis. [FBrf0102325] Young et al., 1993, Genes Dev. 7(1): 29--41 Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function. [FBrf0058526]
Abstract	Williams et al., 2001, A. Dros. Res. Conf. 42: 233B Molecular genetic analysis reveals the role of non-muscle myosin II activity and localization during morphogenesis. [FBrf0134243]

Allele Dmel\zipmhc-c2.1

Allele Dmel\zip^mhc-c2.1