FlyBase Allele Report: Dmel\Cdc42[UAS.cLa]

General Information

Symbol

Dmel\Cdc42^UAS.cLa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct of Luo

FlyBase ID

FBal0038151

Feature type

allele

Associated gene

Dmel\Cdc42

Associated Insertion(s)

Carried in Construct

P{UAS-Cdc42.L}

Key Links

Transgenic product class

cDNA

(Luo et al., 1994)

wild_type

(Luo et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Luo et al., 1994)

wild_type

(Luo et al., 1994)

Mutagen

in vitro construct

(Luo et al., 1994)

Progenitor genotype

Carried in construct

P{UAS-Cdc42.L}

Cytology

Description

UASt regulatory sequences drive expression of a Cdc42 cDNA.

(Luo et al., 1994)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Cdc42

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage, with Scer\GAL4^109-30

(Younger, 2001.2)

lethal - all die before end of larval stage, with Scer\GAL4^109-39

(Younger, 2001.2)

lethal - all die before end of larval stage, with Scer\GAL4^109-53

(Younger, 2001.2)

lethal - all die before end of larval stage, with Scer\GAL4^109-69

(Younger, 2001.2)

lethal - all die before end of larval stage, with Scer\GAL4^109-79

(Younger, 2001.2)

lethal - all die before end of larval stage, with Scer\GAL4^sca-109-68

(Younger, 2001.2)

some die during larval stage, with Scer\GAL4^109-30

(Younger, 2001.2)

some die during larval stage, with Scer\GAL4^109-39

(Younger, 2001.2)

some die during larval stage, with Scer\GAL4^109-53

(Younger, 2001.2)

some die during larval stage, with Scer\GAL4^109-69

(Younger, 2001.2)

some die during larval stage, with Scer\GAL4^109-79

(Younger, 2001.2)

some die during larval stage, with Scer\GAL4^sca-109-68

(Younger, 2001.2)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Cdc42^UAS.cLa/Scer\GAL4^elav.PLu partially rescues Cdc42⁴

(Scott et al., 2003)

Comments

Expression of Cdc42^Scer\UAS.cLa under the control of Scer\GAL4^elav.PLu rescues the dendritic caliber and branching pattern phenotype of Cdc42⁴ mutants in VS1 neurons. However, this expression is unable to rescue many of the VS1 defects such as dendrites being significantly longer than in wild-type and reduction of well developed dendritic spines.

(Scott et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cdc42^Scer\UAS.cLa

Cdc42^UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct of Luo

(Luo et al., 1994)

Secondary FlyBase IDs

References (3)

Report Sections

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