tergal depressor of trochanter muscle motor neuron & dendrite, with Scer\GAL4shakB.lethal.4.1
Expression of Cdc42V12.Scer\UAS under the control of Scer\GAL4twi.PU partially rescues mesodermal cell morphology in pbl2/pbl3 embryos: cellular protrusions are restored (although they appear larger and more elaborate than normal), but the defect in cell rounding is not rescued.
Expression of Cdc42V12.Scer\UAS under the control of Scer\GAL4He.PZ rescues the reduced phagocytosis index against E. coli and S. aureus seen in isolated plasmatocytes from homozygous ZirBG00267 larvae.
The addition of Cdc42V12.Scer\UAS (driven by Scer\GAL4ftz.ng) to robo1/+ embryos has no effect on the midline crossover phenotype seen in the pCC/MP2 pathway axons. The addition of Cdc42V12.Scer\UAS (driven by Scer\GAL4ftz.ng) to Sose49 homozygous embryos enhances the midline crossover phenotype seen in the pCC/MP2 pathway axons. All embryos exhibit the phenotype. The addition of chicsand-1 to Cdc42V12.Scer\UAS suppresses the midline crossover phenotypes in the pCC/MP2 pathway axons. 45.5% of embryos exhibit the phenotype. An average of 1.9 crossovers are seen per embryo.
Expression of Cdc42V12.Scer\UAS under the control of Scer\GAL4btl.PS in a bnl00857 background show occasional (4.4%) fusions of the adjacent lollipop-like dorsal trunk structures (bnl00857 single mutants show no fusion of the adjacent metameric tracheal units).
When Rac1N17.hs is co-expressed with Cdc42V12.Scer\UAS under the control of Scer\GAL4hs.PB most cuticles are extremely disrupted. There is evidence of some rescue of the Rac1N17.hs phenotype by Cdc42V12.Scer\UAS expressed under the control of Scer\GAL4hs.PB, as there are greater numbers of wild-type and mild dorsal closure defective embryos than seen with the expression of Rac1N17.hs alone.