Allele Dmel\Rac1^N17.Scer\UAS

General Information
Symbol	Dmel\Rac1^N17.Scer\UAS	Species	D. melanogaster
Name		FlyBase ID	FBal0038994
Feature type	allele	Associated gene	Dmel\Rac1
Also Known As	Rac^N17, DRac1^N17

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02	Controlled Vocabulary Terms touch sensitivity defective sensory dendrite retina dorsal multidendritic neuron ddaA
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Luo et al., 1994, Eaton et al., 1995, Eaton et al., 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference A dominant negative form of Rac1 is expressed under the control of Scer\UAS regulatory sequences. (Eaton et al., 1995, Eaton et al., 1996) Construct: Amino acid replacement: T17N. A dominant-negative form of Rac1 is expressed under the control of Scer\UAS regulatory sequences. (Luo et al., 1994)
Carried in construct	P{UAS-Rac1.N17} (Silver et al., 2005, Barrett et al., 1997, Sanchez-Soriano and Prokop, 2005, Fernandes et al., 2005, Silver, 2005, Medioni and Noselli, 2005, Bashaw et al., 2001, Hu et al., 2001, Kaufmann et al., 1998, Sepp and Auld, 2003, Prokopenko et al., 1999, Woolner et al., 2005, Raymond et al., 2001, Lee and Kolodziej, 2002, Hu et al., 2005, Hacker and Perrimon, 1998, Suzanne et al., 2001, Duchek et al., 2001, Jones and Bejsovec, 2005, Harden et al., 2002, Magie et al., 2002, Simoes et al., 2006, Lawrence et al., 2002, Fritz and VanBerkum, 2002, Kunwar et al., 2003, Geisbrecht and Montell, 2004, Geisbrecht and Montell, 2002, Dutta et al., 2004, Fan et al., 2003, Strutt et al., 2002, Fanto et al., 2000, Fanto, 2000, Chang and Ready, 2000, Luo et al., 1994, Benlali et al., 2000, Bateman et al., 2000, Martin-Bermudo et al., 1999, Paululat et al., 1999, Harden et al., 1999, Ricos et al., 1999, Olofsson and Page, 2005, Sotillos and Campuzano, 2000, Zettervall et al., 2004, Albin and Davis, 2004, Emoto et al., 2004, Murphy and Montell, 1996, Eaton et al., 1995, Dobens et al., 2001, Kim et al., 2003, Hou et al., 1997, Eaton et al., 1996, Long et al., 2006, Huelsmann et al., 2006, Stramer et al., 2005, Hozumi et al., 2006, Srahna et al., 2006, Geisbrecht et al., 2008, Pirraglia et al., 2006, Leiss et al., 2009, Korolchuk et al., 2007, Allen et al., 2000, Wang et al., 2010, Wang et al., 2010, Paladi and Tepass, 2004, Garlena et al., 2010, Sato et al., 2010, Assaker et al., 2010, Song and Giniger, 2011, Shuai et al., 2011, Kuzina et al., 2011, van Impel et al., 2009, Renault et al., 2010, Kim et al., 2010, Morris et al., 2012, Elsaesser et al., 2010, Raymond et al., 2004, Tsubouchi et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	cell shape defective, with Scer\GAL4^332.3 (Harden et al., 2002) developmental rate defective, with Scer\GAL4¹¹⁵¹ (Fernandes et al., 2005) lethal, with Scer\GAL4^elav.PLu (Fritz and VanBerkum, 2002) lethal \| embryonic stage, with Scer\GAL4⁶⁰ (Luo et al., 1994) lethal \| embryonic stage, with Scer\GAL4^69B (Geisbrecht and Montell, 2004) lethal \| embryonic stage, with Scer\GAL4^pnr-MD237 (Geisbrecht and Montell, 2004) lethal \| embryonic stage \| recessive, with Scer\GAL4^unspecified (Hou et al., 1997) neuroanatomy defective, with Scer\GAL4⁶⁰ (Song and Giniger, 2011) neuroanatomy defective, with Scer\GAL4^A307 (Allen et al., 2000) neuroanatomy defective, with Scer\GAL4^ato.3.6 (Srahna et al., 2006) neuroanatomy defective, with Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) neuroanatomy defective, with Scer\GAL4^GMR.PF (Long et al., 2006) neuroanatomy defective \| adult stage, with Scer\GAL4^DB331 (Leiss et al., 2009) neuroanatomy defective \| larval stage, with Scer\GAL4^1003.3 (Tsubouchi et al., 2012) oxidative stress response defective, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B (Shuai et al., 2011) planar polarity defective, with Df(3L)Ar14-8, Scer\GAL4^hs.2sev (Fanto et al., 2000) planar polarity defective, with Scer\GAL4^hs.2sev (Fanto et al., 2000) planar polarity defective \| somatic clone, with Scer\GAL4^hs.2sev (Strutt et al., 2002) starvation stress response defective, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B (Shuai et al., 2011) stress response defective, with Scer\GAL4^Cha.7.4, Scer\GAL80^ts.αTub84B (Shuai et al., 2011) stress response defective, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B (Shuai et al., 2011) touch sensitivity defective \| larval stage, with Scer\GAL4^1003.3 (Tsubouchi et al., 2012) viable, with Scer\GAL4^198Y (Murphy and Montell, 1996) viable, with Scer\GAL4²¹² (Murphy and Montell, 1996) viable, with Scer\GAL4³⁰⁶ (Murphy and Montell, 1996) viable, with Scer\GAL4⁴⁵⁸ (Murphy and Montell, 1996) viable, with Scer\GAL4^hs.PB (Murphy and Montell, 1996) visible, with Df(3L)Ar14-8, Scer\GAL4^hs.2sev (Fanto et al., 2000) visible, with Scer\GAL4^GMR.PF (Schenck et al., 2003) visible, with Scer\GAL4^GMR.PU (Raymond et al., 2004) visible, with Scer\GAL4^hs.2sev (Fanto et al., 2000) visible, with Scer\GAL4^sd-SG29.1 (Sotillos and Campuzano, 2000) visible, with Scer\GAL4^sev.EP (Morris et al., 2012)
Phenotype Manifest In
	A1-7 lateral longitudinal muscle 1, with Scer\GAL4¹¹⁵¹ (Dutta et al., 2004) abdominal intersegmental nerve (Kaufmann et al., 1998) abdominal intersegmental nerve, with Scer\GAL4^elav.PLu (Kaufmann et al., 1998) abdominal intersegmental nerve, with Scer\GAL4^elav-C155 (Kaufmann et al., 1998) abdominal intersegmental nerve, with Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) abdominal segmental nerve (Kaufmann et al., 1998) abdominal segmental nerve, with Scer\GAL4^elav.PLu (Kim et al., 2003, Kaufmann et al., 1998, Hu et al., 2001) abdominal segmental nerve, with Scer\GAL4^elav-C155 (Kaufmann et al., 1998) aCC neuron, with Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) adult muscle precursor cell, with Scer\GAL4¹¹⁵¹ (Fernandes et al., 2005) amnioserosa, with Scer\GAL4^332.3 (Harden et al., 2002) axon & dorsal cluster neuron, with Scer\GAL4^ato.3.6 (Srahna et al., 2006) border follicle cell, with Scer\GAL4^198Y (Murphy and Montell, 1996) border follicle cell, with Scer\GAL4³⁰⁶ (Murphy and Montell, 1996) border follicle cell, with Scer\GAL4⁴⁵⁸ (Murphy and Montell, 1996) border follicle cell, with Scer\GAL4^hs.PB (Murphy and Montell, 1996) border follicle cell, with Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004, Medioni and Noselli, 2005, Silver, 2005, Assaker et al., 2010) coxal tergal remotor muscle, with Scer\GAL4¹¹⁵¹ (Fernandes et al., 2005, Dutta et al., 2004) crystal cell, with Scer\GAL4^He.PZ (Zettervall et al., 2004) dendrite, with Scer\GAL4^A307 (Allen et al., 2000) dendritic spine & lobular plate tangential neuron, with Scer\GAL4^DB331 (Leiss et al., 2009) dorsal appendage, with Scer\GAL4^CY2 (Suzanne et al., 2001) dorsal appendage, with Scer\GAL4^T155 (Suzanne et al., 2001) dorsal closure embryo, with Scer\GAL4^69B (Geisbrecht and Montell, 2004) dorsal closure embryo, with Scer\GAL4^332.3 (Harden et al., 2002) dorsal closure embryo, with Scer\GAL4^c381 (Harden et al., 2002) dorsal closure embryo, with Scer\GAL4^hs.PB (Ricos et al., 1999) dorsal closure embryo, with Scer\GAL4^pnr-MD237 (Geisbrecht and Montell, 2004) dorsal group branch precursor, with Scer\GAL4^btl.PS (Chihara et al., 2003) dorsal medial muscle, with Scer\GAL4¹¹⁵¹ (Fernandes et al., 2005) dorsal multidendritic neuron ddaA \| larval stage, with Scer\GAL4^1003.3 (Tsubouchi et al., 2012) dorsal trunk primordium, with Scer\GAL4^btl.PS (Chihara et al., 2003) embryonic/first instar larval cuticle, with Scer\GAL4^332.3 (Harden et al., 2002) embryonic/first instar larval cuticle, with Scer\GAL4^arm.PS (Jones and Bejsovec, 2005) embryonic/first instar larval cuticle, with Scer\GAL4^c381 (Harden et al., 2002) embryonic/first instar larval cuticle, with Scer\GAL4^twi.PG (Hacker and Perrimon, 1998) embryonic/first instar larval cuticle \| dorsal, with Scer\GAL4^69B (Geisbrecht and Montell, 2004) embryonic/first instar larval cuticle \| dorsal, with Scer\GAL4^hs.PB (Harden et al., 1999) embryonic/first instar larval cuticle \| dorsal, with Scer\GAL4^pnr-MD237 (Geisbrecht and Montell, 2004) embryonic/first instar larval cuticle \| dorsal, with Scer\GAL4^ptc-559.1 (Harden et al., 1999, Raymond et al., 2001) embryonic/larval hindgut, with Scer\GAL4^NP2432 (Taniguchi et al., 2011) embryonic/larval midgut \| embryonic stage, with Scer\GAL4^48Y (Martin-Bermudo et al., 1999) embryonic dorsal epidermis, with Scer\GAL4^unspecified (Hou et al., 1997) embryonic epidermis, with Scer\GAL4^332.3 (Harden et al., 2002) embryonic epidermis, with Scer\GAL4^c381 (Harden et al., 2002) embryonic hemocyte, with Scer\GAL4^crq.PO (Olofsson and Page, 2005) embryonic hemocyte, with Scer\GAL4^Pxn.PS, Scer\GAL4^crq.PA (Stramer et al., 2005) embryonic leading edge cell & actin filament, with Scer\GAL4^en-e16E (Woolner et al., 2005) embryonic segment, with Scer\GAL4^en-e16E (Woolner et al., 2005) eye, with Df(3L)Ar14-8, Scer\GAL4^hs.2sev (Fanto et al., 2000) eye, with Scer\GAL4^GMR.PF (Schenck et al., 2003) eye, with Scer\GAL4^GMR.PU (Geisbrecht et al., 2008, Raymond et al., 2004) eye, with Scer\GAL4^hs.2sev (Fanto et al., 2000) eye, with Scer\GAL4^sev.EP (Morris et al., 2012) eye disc, with Scer\GAL4^ey.PH (Benlali et al., 2000) eye photoreceptor cell, with Scer\GAL4^GMR.PU (Raymond et al., 2004) eye photoreceptor cell \| somatic clone, with Scer\GAL4^hs.2sev (Strutt et al., 2002) giant axon, with Scer\GAL4^A307 (Allen et al., 2000) hemocyte, with Scer\GAL4^He.PZ (Zettervall et al., 2004) indirect flight muscle \| larval stage, with Scer\GAL4¹¹⁵¹ (Fernandes et al., 2005) intersegmental nerve, with Scer\GAL4^elav.PLu (Hu et al., 2001) intersegmental nerve, with Scer\GAL4^elav-C155 (Bateman et al., 2000) intersegmental nerve, with Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) lamellipodium, with Scer\GAL4^en-e16E (Woolner et al., 2005) lamellocyte, with Scer\GAL4^He.PZ (Zettervall et al., 2004) lamina, with Scer\GAL4^GMR.PF (Long et al., 2006) lateral oblique dorsal muscle, with Scer\GAL4¹¹⁵¹ (Fernandes et al., 2005, Dutta et al., 2004) longitudinal connective, with Scer\GAL4^elav-C155 (Bateman et al., 2000) macrophage, with Scer\GAL4^{Cg25C-A109.1F2.P} (Paladi and Tepass, 2004) macrophage, with Scer\GAL4^gcm-rA87.P (Paladi and Tepass, 2004) macrophage, with Scer\GAL4^unspecified (Paladi and Tepass, 2004) medial longitudinal fascicle, with Scer\GAL4^elav.PLu (Hu et al., 2005) medulla, with Scer\GAL4^GMR.PF (Long et al., 2006) mesothoracic intersegmental nerve, with Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) metathoracic intersegmental nerve, with Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) microchaeta & wing, with Scer\GAL4^ptc-559.1 (Eaton et al., 1995, Eaton et al., 1996) motor neuron, with Scer\GAL4^elav.PLu (Kim et al., 2003) myoblast, with Scer\GAL4^how-24B (Geisbrecht and Montell, 2004) neurite, with Scer\GAL4^A307 (Allen et al., 2000) nurse follicle cell, with Scer\GAL4^Act5C.PP (Dobens et al., 2001) ommatidium, with Df(3L)Ar14-8, Scer\GAL4^hs.2sev (Fanto et al., 2000) ommatidium, with Scer\GAL4^GMR.PF (Schenck et al., 2003) ommatidium, with Scer\GAL4^hs.2sev (Fanto et al., 2000) ommatidium \| somatic clone, with Scer\GAL4^hs.2sev (Strutt et al., 2002) peripheral glial cell, with Scer\GAL4^repo (Sepp and Auld, 2003) polar follicle cell, with Scer\GAL4^slbo.2.6 (Medioni and Noselli, 2005) presumptive embryonic/larval tracheal system, with Scer\GAL4^btl.PS (Lee and Kolodziej, 2002) presumptive embryonic salivary gland, with Scer\GAL4^fkh.PH (Pirraglia et al., 2006) prothoracic intersegmental nerve, with Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) retina, with Scer\GAL4^GMR.PU (Raymond et al., 2004) rhabdomere, with Scer\GAL4^GMR.PU (Raymond et al., 2004) rhabdomere, with Scer\GAL4^unspecified (Chang and Ready, 2000) rhabdomere & actin filament, with Scer\GAL4^unspecified (Chang and Ready, 2000) rhabdomere & microvillus, with Scer\GAL4^unspecified (Chang and Ready, 2000) RP2 motor neuron, with Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) sensory dendrite \| larval stage, with Scer\GAL4^1003.3 (Tsubouchi et al., 2012) tergosternal muscle, with Scer\GAL4¹¹⁵¹ (Fernandes et al., 2005, Dutta et al., 2004) tracheal branch primordium, with Scer\GAL4^btl.PS (Chihara et al., 2003) ventral midline, with Scer\GAL4^elav.PLu (Hu et al., 2005) ventral midline, with Scer\GAL4^en-e16E (Woolner et al., 2005) ventral nerve cord \| embryonic stage, with Scer\GAL4¹⁵⁸ (Olofsson and Page, 2005) ventral nerve cord \| embryonic stage, with Scer\GAL4^crq.PO (Olofsson and Page, 2005) wing, with Scer\GAL4^ptc-559.1 (Eaton et al., 1995) wing, with Scer\GAL4^sd-SG29.1 (Sotillos and Campuzano, 2000) wing \| anterior compartment, with Scer\GAL4^ptc-559.1 (Eaton et al., 1995) wing disc, with Scer\GAL4^ptc-559.1 (Eaton et al., 1995)
Detailed Description
	Statement Reference Class III ddaA neurons expressing Rac1[N17.Scer\UAS] under the control of Scer\GAL4[1003.3] show a significant decrease in the number of dendritic sensory filopodia compared to wild type. The average length of the filopodia is significantly decreased compared to wild type, while the total length of primary dendritic branches is not altered. Larvae expressing Rac1[N17.Scer\UAS] under the control of Scer\GAL4[1003.3] show a reduced response to gentle touch compared to controls. (Tsubouchi et al., 2012) Flies with induced expression of Rac1[N17.Scer\UAS] for three days under the control of Scer\GAL4[elav-C155] and Scer\GAL80[ts.αTub84B] show a remarkable tolerance to paraquat-induced oxidative stress, desiccation, starvation and high temperature. These flies survive for 50-100% longer than control flies in adverse conditions. The body weight of flies expressing of Rac1[N17.Scer\UAS] for three days under the control of Scer\GAL4[elav-C155] and Scer\GAL80[ts.αTub84B] is largely comparable to un-induced controls, although a marginal but statistically significant increase is found in males. The level of triglyceride, the primary storage form of lipid, is not altered either. The fecundity of female flies as determined by the number of eggs laid per fly per day is not compromised compared to that of controls. Continuous expression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[elav-C155] and Scer\GAL80[ts.αTub84B] (with flies kept at 30[o]C) does not confer any obvious beneficial or detrimental effects on life span. Flies with induced expression of Rac1[N17.Scer\UAS] for three days under the control of Scer\GAL4[Cha.7.4] and Scer\GAL80[ts.αTub84B] exhibit improved survival rates compared to controls when exposed to 20 mM paraquat and desiccation. Flies with induced expression of Rac1[N17.Scer\UAS] for three days under the control of Scer\GAL4[repo] and Scer\GAL80[ts.αTub84B] do not exhibit improved survival rates compared to controls when exposed to 20 mM paraquat and desiccation. (Shuai et al., 2011) Expression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[60] results in a low frequency of axonal 'stalling' phenotypes. (Song and Giniger, 2011) Hindgut epithelial cells do not show the left-right asymmetry in cell shape which is seen in wild-type hindgut epithelial cells at late stage 12 (before epithelial tube rotation) in embryos expressing Rac1[N17.Scer\UAS] under the control of Scer\GAL4[NP2432]. (Taniguchi et al., 2011) Expression of Rac1[N17.Scer\UAS] driven by Scer\GAL4[slbo.2.6] results in the impairment of border cell migration during egg chamber development. (Assaker et al., 2010) Expression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[nos.UTR.T:Hsim\VP16] does not block germ cell transepithelial migration or later germ cell migration. (Renault et al., 2010) Expression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[DB331] does not alter the overall dendritic architecture in the lobular plate tangential cells; neither the position not branching patterns of primary and secondary order dendrites are affected. However, there is an increase in spine density and a change in spine morphology (the spines appear shorter and less well defined) compared to controls. (Leiss et al., 2009) Scer\GAL4[GMR.PU]-mediated expression of Rac1[N17.Scer\UAS] results in a severe rough eye. (Geisbrecht et al., 2008) Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^GMR.PF results in a weak axonal hyperfasciculation phenotype in the lamina and medulla. (Long et al., 2006) The salivary gland fails to migrate posteriorly and some cells remain at the ventral surface in embryos expressing Rac1[N17.Scer\UAS] under the control of Scer\GAL4[fkh.PH]. (Pirraglia et al., 2006) Expression of Rac1^N17.Scer\UAS under the control of cer\GAL4^ato.3.6 results in a marked increase in the number of axons from dorsal cluster neurons crossing the optic chiasm (an average of only 19.8 axons crossing in contrast to the wild-type average of 11.7). (Srahna et al., 2006) Expression of Rac1^N17.Scer\UAS in myoblasts, driven by Scer\GAL4¹¹⁵¹, affects indirect flight muscles. There is a reduction in the mean number of dorsal longitudinal muscle (DLM) fibers (from 6 to ~4) and in DLM size (35% reduction in area). Additionally, the tergal depressor of trochanter (TDT) and the dorso-ventral muscles (DVMs) are almost completely absent. Expression of Rac1^N17.Scer\UAS, under the control of Scer\GAL4¹¹⁵¹, does not affect the number of adult muscle precursors present at late embryonic stages. However, there is an approximately 43% reduction in the number of myoblast numbers in the wing discs of third instar larva. Experiments using Scer\GAL80^ts.αTub84B show that Rac1^N17.Scer\UAS needs to be expressed during larval stages to affect muscle development. Expression of Rac1^N17.Scer\UAS, under the control of Scer\GAL4¹¹⁵¹, affects pupal myogenesis. DLM myoblast expansion and proliferation follows a different pattern in Scer\GAL4¹¹⁵¹/+; Rac1^N17.Scer\UAS/+ mutants compared to controls: in the mutants there is no significant increase of proliferation at 12-16 hours APF and there is a sharp decline in expanse by 20 hours APF. At 16 hours APF, Scer\GAL4¹¹⁵¹/+; Rac1^N17.Scer\UAS/+ myoblasts undergo less fusion than controls. Fiber formation is delayed compared to controls, and by 24 hours APF, the majority of Scer\GAL4¹¹⁵¹/+; Rac1^N17.Scer\UAS/+ mutants have only 3 DLM fibers, instead of the wild-type number of 6. Pupal myogenesis is severely affected in the DVMs of Scer\GAL4¹¹⁵¹/+; Rac1^N17.Scer\UAS/+ mutants. Myoblast proliferation fails to increase at 12-16 hours APF and there is a sharp decline at 20 hours APF. At 16 hours APF, Scer\GAL4¹¹⁵¹/+; Rac1^N17.Scer\UAS/+ DVM myoblasts are disorganized and are not aligned along the long axis of the founder cells, as occurs in wild type. At 20-24 hours APF, control myoblasts become compact and rounded, while Scer\GAL4¹¹⁵¹/+; Rac1^N17.Scer\UAS/+ DVM myoblasts fail to assume this shape. Myoblast segregation and fusion does not occur in the mutants. By 20 hours APF, when DVM fiber formation is complete in controls, myoblasts of Scer\GAL4¹¹⁵¹/+; Rac1^N17.Scer\UAS/+ mutants remain unpatterned. (Fernandes et al., 2005) When Rac1^N17.Scer\UAS is driven by Scer\GAL4^elav.PLu, embryos display mild midline axon outgrowth defects, with small breaks in the outermost longitudinal pathways, with rare axons ectopically crossing the midline. (Hu et al., 2005) Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^arm.PS does not affect ventral patterning in the embryo, but causes a dorsal hole phenotype. (Jones and Bejsovec, 2005) Expression of Rac1^N17.Scer\UAS in border cells, driven by Scer\GAL4^slbo.2.6, inhibits the migration of border cell clusters to the oocyte. However, the apical cap of these egg chambers forms and is shed normally. (Medioni and Noselli, 2005) Expression of Rac1^N17.Scer\UAS, under the control of the hemocyte-specific driver Scer\GAL4^crq.PO, inhibits hemocyte migration in the embryo by stage 14. Hemocytes begin migration out of the head region, but then lose polarized migration and accumulate in the anterior of the embryo. At stage 17, the ventral nerve cord is shorter in Rac1^N17.Scer\UAS embryos than in wild-type, indicating that the VNC fails to condense correctly in Rac1^N17.Scer\UAS mutants. Expression of Rac1^N17.Scer\UAS in the lateral glia, driven by Scer\GAL4¹⁵⁸, results in inhibition of VNC condensation in embryos but does not affect the differentiation or survival of the lateral glial cells. Expression of Rac1^N17.Scer\UAS throughout the CNS, driven by Scer\GAL4^elav-C155, does not affect the condensation of the VNC in embryos. (Olofsson and Page, 2005) Expression of Rac1^N17.Scer\UAS in the aCC/RP2 axons (under the control of Scer\GAL4^eve.RN2), results in stalling in 15.2% of hemisegments. Stalled aCC/RP2 axons cause a co-arrest of the complete intersegmental motor nerve in 90% of cases. (Sanchez-Soriano and Prokop, 2005) Expression of Rac1^N17.Scer\UAS, under the control of Scer\GAL4^slbo.2.6, inhibits border cell migration. (Silver, 2005) Developmental dispersal of hemocytes is abnormal in embryos expressing Rac1^N17.Scer\UAS under the simultaneous control of both Scer\GAL4^Pxn.PS and Scer\GAL4^crq.PA. One hour after laser-induced wounding, approximately half the number of hemocytes are recruited to the wound in embryos expressing Rac1^N17.Scer\UAS under the simultaneous control of both Scer\GAL4^Pxn.PS and Scer\GAL4^crq.PA compared to wild type embryos. Hemocytes that are recruited in the mutant embryos have significantly reduced lamellar protrusions. (Stramer et al., 2005) Expression of Rac1^N17.Scer\UAS in segmental stripes of the embryonic epithelium, driven by Scer\GAL4^en-e16E, inhibits the production of actin protrusions and the actin cable within epithelial cells. These embryos are able to complete dorsal closure but the Rac1^N17.Scer\UAS-expressing cells fail to fuse properly, which results in the presence of small holes in the midline. These embryos also show segmental mismatching along the midline. (Woolner et al., 2005) Expression of Rac1^N17.Scer\UAS in the muscle, under the regulation of Scer\GAL4^Mhc.PW has no effect on synapse development. (Albin and Davis, 2004) Rac1^N17.Scer\UAS; Scer\GAL4¹¹⁵¹ pupae have severely reduced myoblast fusion, the effect being most dramatic in the lateral muscles of the abdomen and, to a lesser extent, in the thoracic muscles. The lateral muscles of the abdomen in these pupae don't fuse and the resulting unfused myoblasts cluster around founder myoblasts, but do not differentiate further. Each unfused founder cell elongates and differentiates into a thin myotube eventually eventually developing into a mononucleate fibre. By contrast, some fusion does occur in the developing dorso-ventral indirect flight muscles. The putative founders myoblasts of these muscles are present in the pupal thorax in a wild-type pattern. These founders initiate fibre formation, but to a lesser extent than normal, leading to the formation of fibres with fewer nuclei than wild-type fibres of the same stage. The resulting muscles are abnormally thin, but form at the correct position and with the correct number of fibres. (Dutta et al., 2004) When Rac1^N17.Scer\UAS is driven by Scer\GAL4⁴⁷⁷, no detectable phenotype is seen in dendrites. (Emoto et al., 2004) Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 results in defects in border follicle cell migration in more than 95% of stage 10 egg chambers. Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 does not results in apoptotic cells in stage 10 egg chambers. Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^69B or Scer\GAL4^pnr-MD237 results in a failure of dorsal closure and lethality. Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^how-24B results in dramatic defects in myoblast fusion. (Geisbrecht and Montell, 2004) Expression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[gcm-rA87.P] blocks macrophage migration in embryos; only a few macrophages move anteriorly and posteriorly for short distances. Expression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[Cg25C-A109.1F2.P] causes macrophages to clump in various areas of the embryo (such as the head region, around the pharynx, midgut and hindgut and laterally along the ventral cord). This defect is seen at stage 16, but becomes more pronounced during stage 17. The macrophages are abnormal in shape in the mutant embryos, appearing rounder than normal due to a block in the formation of cellular protrusions. Macrophages expressing Rac1[N17.Scer\UAS] under the control of Scer\GAL4[unspecified] show wild-type levels of cortical F-actin. The macrophages have few or no cytoplasmic extensions in the mutant embryos. (Paladi and Tepass, 2004) Flies expressing Rac1[N17.Scer\UAS] under the control of Scer\GAL4[GMR.PU] have rough eyes with a loss of rhabdomeres, abnormal photoreceptor cells, vacuolated material in the retina and polarity defects. (Raymond et al., 2004) When expression is driven by Scer\GAL4^He.PZ, hemocyte proliferation is unaffected, lamellocytes are abnormal and replaced by multinucleate cells that do not express lamellocyte markers and crystal cells are decreased. (Zettervall et al., 2004) Rac1^N17.Scer\UAS; Scer\GAL4^btl.PS embryos have tracheal defects including truncated and/or zig-zagged dorsal trunk, misguided dorsal branches and a lack of terminal branches. The cell rearrangements occurring during extension of the dorsal branches towards the dorsal midline are greatly inhibited in these embryos: migration of cells to form the dorsal branch begins, but the number of cells contributed is less than in wild-type, and the resulting dorsal branches are shorter, occasionally failing to form at all. (Chihara et al., 2003) When Rac1^N17.Scer\UAS is overexpressed under the control of Scer\GAL4^elav.PLu, mutants do not exhibit longitudinal axon ectopic midline crossing defects. (Fan et al., 2003) Although Rac1^N17.Scer\UAS; Scer\GAL4^elav.PLu embryos have occasional defects in the segmental nerve (SN)b and SNa motoneurons, they always extend their axons out of the CNS (as part of the abdominal posterior fascicle). In some cases (16%), the lateral branch of SNa motor axon actually extends beyond its target muscles. (Kim et al., 2003) Rac1^N17.Scer\UAS driven by Scer\GAL4^GMR.PF gives a rough eye phenotype. (Schenck et al., 2003) When Rac1^N17.Scer\UAS is driven by Scer\GAL4^repo, mutant embryos have mildly disrupted glial wrapping profiles with occasional small gaps in the nerve sheath. Sensory neurons also show defasciculation. (Sepp and Auld, 2003) When Rac1^N17.Scer\UAS is driven by Scer\GAL4^ftz.ng, no midline crossovers are seen in the pCC/MP2 pathway axons. When Rac1^N17.Scer\UAS is driven by Scer\GAL4^elav.PLu, no adults eclose. (Fritz and VanBerkum, 2002) Expression of Rac1^N17.Scer\UAS, driven by Scer\GAL4^332.3, causes a failure to secrete cuticle in 61% of embryos and holes in the dorsal surface of 8% of embryos that do manage cuticle secretion. Expression of Rac1^N17.Scer\UAS, driven by Scer\GAL4^332.3, results in impairment of amnioserosa morphogenesis and migration of the epidermis. The amnioserosa of these mutants remains elliptical at an age where the same tissue is narrowing in wild type. This lack of morphological change appears to impede the movement of the epidermis resulting in a dorsal hole which is larger than in wild type. Within a single mutant embryo there may be patches of cells that change shape correctly and patches that do not. The progression of the epidermis is impeded more around patches of cells that have failed to change shape. Overexpression of Rac1^N17.Scer\UAS driven by Scer\GAL4^c381 does not cause failure of cuticle formation. However, embryos do fail to complete dorsal closure and have a large dorsal hole in the cuticle extending from the middle of the dorsal surface to the rear of the embryo. Additionally, the epidermis fails to migrate over the amnioserosa. (Harden et al., 2002) Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^btl.PS does not affect lumen formation in the tracheal system although these embryos do show some defects in tracheal branch migration. (Lee and Kolodziej, 2002) 77.6% of ommatidia in mutant somatic clones (driven by Scer\GAL4^hs.2sev) in the eye are normal. 18.1% have rotated ommatidia, 0.5% have chirality defects, 0.7% are achiral (3.1% unscorable). (Strutt et al., 2002) Co-expression of Rac1^N17.Scer\UAS has little or no effect on the gain of function axon guidance defects caused by expression of Gef64C^EP3035 under the control of Scer\GAL4^elav.PLu. (Bashaw et al., 2001) Clones of cells expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^Act5C.PP in the nurse cell follicle cells results in aberrant morphology. (Dobens et al., 2001) When Rac1^N17.Scer\UAS is driven by Scer\GAL4^elav.PLu dramatic effects are seen on axon guidance. The intersegmental nerve b (ISNb) fails to branch off and enter the ventral muscles and instead follows the ISN distally toward dorsal muscles. The SNa motor axons also sometimes abnormally project to lateral muscle targets, bypassing their normal targets. (Hu et al., 2001) Embryos expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^ptc-559.1 have a dorsal hole. (Raymond et al., 2001) Eggs derived from females expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^T155 have short dorsal appendages. Eggs derived from females expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^CY2 show a failure of the dorsal appendages to elongate. (Suzanne et al., 2001) Approximately 70% of axons expressing Rac1[N17.Scer\UAS] under the control of Scer\GAL4[A307] exhibit morphological abnormalities such as excess branching in the target region. The axons often send ectopic projections across the midline into the contralateral side of the ganglion in T2 or extra processes down into T3, a phenotype never seen in controls. In some cases one GF splits and makes bilateral bends while its partner grows on into T3 without making any bend. Often the axons split several times sending a number of projections to inappropriate parts of the ganglion. In addition to these extra processes the lateral bends, along which the synapse with the TTMn can be formed, are always seen in T2. The function of the GF-TTMn synapse in Scer\GAL4[A307]; Rac1[N17.Scer\UAS] flies in both the response latency and the percentage following at 250Hz are normal. Dendritic defects are seen in about 25% of Scer\GAL4[A307]; Rac1[N17.Scer\UAS] GFs. The dendritic field always contains its distinct domains, but the large dendrites have a brush-like appearance with many small processes emanating from the larger ones. Approximately 81% of Scer\GAL4[A307]; Rac1[Scer\UAS.cLa] flies exhibit a bendless GF phenotype, while 64% of Scer\GAL4[A307]; Rac1[Scer\UAS.cLa] GFs are bendless. The remainder exhibit wild-type bends or large abnormally shaped processes in the target region. (Allen et al., 2000) When expression is driven by Scer\GAL4^elav-C155, ISNb shows a bypass phenotype. The CNS shows similar breaks in longitudinal connectives to those of trio loss of function mutants. (Bateman et al., 2000) Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^ey.PH results in uncoordinated differentiation in the eye disc. (Benlali et al., 2000) Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^unspecified during rhabdomere morphogenesis results in reduced, disorganised rhabdomeres. Fewer microvilli than normal are seen in cross section and a well-defined rhabdomere base is not formed; apposed sheets of membrane are involuted into the photoreceptor cytoplasm. The actin cytoskeleton appears diffuse and disordered. (Chang and Ready, 2000) Rac1^N17.Scer\UAS when driven by Scer\GAL4^hs.2sev leads to planar polarity, defects in the eye. This phenotype is enhanced by the addition of Df(3L)Ar14-8, which removes the Rac1 gene. Although it is mostly ommatidial rotation that is randomised in Scer\GAL4^hs.2sev, Rac1^N17.Scer\UAS mutants the enhancement of the phenotype by Df(3L)Ar14-8 increases the number of symmetrical, achiral ommatidia. These phenotypes appear early in development, suggesting they are primary defects. (Fanto et al., 2000) When expression is driven by Scer\GAL4^sd-SG29.1 wing size is reduced. (Sotillos and Campuzano, 2000) Embryos expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^ptc-559.1 or Scer\GAL4^hs.PB (using heat shock) have dorsal holes ranging in size from a small 'scab' to a wide open dorsal surface. (Harden et al., 1999) Expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^48Y in the developing midgut causes a delay in migration of the endodermal midgut cells. (Martin-Bermudo et al., 1999) Expression of Rac1^N17.Scer\UAS by Scer\GAL4^prd.RG1 has no effect on cytokinesis or mitosis. (Prokopenko et al., 1999) Scer\GAL4^twi.PG-mediated expression causes severe cuticle defects. (Hacker and Perrimon, 1998) Scer\GAL4^elav-C155-mediated expression causes ISNb axons to extend past the ventral longitudinal muscles. ISNb axons may also form a distinct fascicle that follows the ISN beyond ventral muscles. Phenotype of segments showing any evidence of ISNb bypass or the full bypass phenotype is more severe with Scer\GAL4¹⁴⁰⁷ or Scer\GAL4^elav.PLu-mediated expression. Scer\GAL4^elav-C155-mediated expression causes the dorsal projection of SNa axons to extend beyond the distal edge of muscle 4 or the axons extend beyond the target site to make ectopic contacts onto dorsal muscles, sensory sheath cells or ISN axons. Phenotype is more severe with Scer\GAL4¹⁴⁰⁷ or Scer\GAL4^elav.PLu-mediated expression. Scer\GAL4^elav-C155-mediated expression causes defects in the morphology of the CNS pathways. Coexpression of Rac1^Scer\UAS.cLa under the same Scer\GAL4 driver yields near normal morphology of the CNS pathways, some abnormalities can be seen in occasional segments. (Kaufmann et al., 1998) Embryos exhibit a dorsal open phenotype. (Hou et al., 1997) Causes duplications and triplications of wing hairs when expressed using Scer\GAL4^ptc-559.1. The duplicated or triplicated hairs are morphologically indistinguishable from wild-type. Actin distribution in Rac1^N17.Scer\UAS expressing cells is abnormal at 30-35 hours after puparium formation, and microtubules appear disorganised 30-32 hours after puparium formation. (Eaton et al., 1996) Scer\GAL4^198Y- or Scer\GAL4³⁰⁶-mediated expression causes no or little border cell migration in 80% stage 10 egg chambers. 19 to 22% of laid eggs hatch. Scer\GAL4⁴⁵⁸-mediated expression causes arrested migration in 10% of stage 10 egg chambers. Removing Rac1 activity during migration (using Scer\GAL4^hs.PB) seems to halt all activity. (Murphy and Montell, 1996) Wing discs expressing Rac1^N17.Scer\UAS using Scer\GAL4^ptc-559.1 often contain dead cells that are extruded from the basal side of the epithelium. Adherens junction actin is disrupted in cells expressing Rac1^N17.Scer\UAS. Wings derived from discs in which Rac1^N17.Scer\UAS is expressed using Scer\GAL4^ptc-559.1 are of normal length but narrow, with the reduction in wing area restricted to the anterior compartment. Wing hairs are often duplicated or triplicated, the penetrance of this phenotype decreasing at the wing margin. (Eaton et al., 1995) Semi-embryonic lethal with Scer\GAL4¹⁴⁰⁷ and Scer\GAL4^elav.PLu and viable with Scer\GAL4⁶⁰. Embryos with Scer\GAL4^how-24B have weak muscle contractions. (Luo et al., 1994)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has neuroanatomy defective phenotype, enhanceable by bur^e10/bur[+] (Long et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by dco^EP3280, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Eip78C^EP3468, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by EP1207^EP1207, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by EP1408^EP1408, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by lilli^EP1211, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by tlk^EP1413, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, enhanceable by tou^EP622, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by bchs^EP2299, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by C3G^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by CG5261^EP816, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by CG6701^EP2054, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by cpo^EP3395, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by grp^EP587, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by P{EP}EP2233, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by P{EP}EP2491, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by SNF4Aγ^EP648, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^sd-SG29.1 has visible phenotype, enhanceable by tum^Scer\UAS.cSa, Scer\GAL4^sd-SG29.1 (Sotillos and Campuzano, 2000)
NOT Enhanced by
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has neuroanatomy defective phenotype, non-enhanceable by btl^Scer\UAS.cDa, Scer\GAL4^ato.3.6 (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has neuroanatomy defective phenotype, non-enhanceable by dsh¹ (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by ago^EP1135, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Amun^EP1503, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Atg1^EP3348, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by ball^EP863, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG1090^EP3028, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG3542^EP719, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG4266^EP2258, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG10082^EP436, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG10082^EP2310, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG10082^EP2440, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG10433^EP2034, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG10433^EP2516, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CHES-1-like^EP1342, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CHES-1-like^EP1453, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Dlc90F^EP3634, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP712^EP712, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP1200^EP1200, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP1340^EP1340, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP2444^EP2444, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by HmgD^EP467, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by lea^EP2582, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by MESR4^EP988, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by NFAT^EP1335, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by NFAT^EP1353, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by NFAT^EP1390, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by NFAT^EP1508, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Sar1^EP3575, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by skd^EP3443, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Smg5^EP2171, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Tao^EP1455, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Tim10^EP541, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Tim10^EP2421, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Tsp42Ef^EP2571, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Akap200^EP2072, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by CG2017^EP3503, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by cindr^EP3700, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by dom^EP2371, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Dp1^EP2422, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by EP474^EP474, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by hppy^EP2445, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by kis^EP563, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by MESR4^EP386, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by P{EP}fax^EP807, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by P{EP}wun^EP652, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by rho-6^EP2023, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by RhoGEF64C^EP3035, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Traf6^EP325, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^sev.EP has visible phenotype, non-enhanceable by CRMP^supK1 (Morris et al., 2012)
Suppressed by
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^69B has lethal \| embryonic stage phenotype, suppressible \| partially by th^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^69B (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has neuroanatomy defective phenotype, suppressible by bsk^DN.Scer\UAS, Scer\GAL4^ato.3.6 (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu, sli² has neuroanatomy defective phenotype, suppressible \| partially by Pak^{Scer\UAS.T:Myr-Src64B}, Scer\GAL4^elav.PLu (Fan et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by CG10082^EP2319, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by EP2204^EP2204, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by cdi^EP3319, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by numb^EP2455, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by poe^EP349, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by poe^EP737, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^pnr-MD237 has lethal \| embryonic stage phenotype, suppressible \| partially by th^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^pnr-MD237 (Geisbrecht and Montell, 2004)
NOT suppressed by
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has neuroanatomy defective phenotype, non-suppressible by btl^Scer\UAS.cDa, Scer\GAL4^ato.3.6 (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has neuroanatomy defective phenotype, non-suppressible by dsh¹ (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by ago^EP1135, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Amun^EP1503, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Atg1^EP3348, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by ball^EP863, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG1090^EP3028, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG3542^EP719, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG4266^EP2258, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG10082^EP436, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG10082^EP2310, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG10082^EP2440, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG10433^EP2034, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG10433^EP2516, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CHES-1-like^EP1342, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CHES-1-like^EP1453, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Dlc90F^EP3634, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP712^EP712, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP1200^EP1200, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP1340^EP1340, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP2444^EP2444, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by HmgD^EP467, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by lea^EP2582, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by MESR4^EP988, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by NFAT^EP1335, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by NFAT^EP1353, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by NFAT^EP1390, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by NFAT^EP1508, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Sar1^EP3575, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by skd^EP3443, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Smg5^EP2171, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Tao^EP1455, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Tim10^EP541, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Tim10^EP2421, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Tsp42Ef^EP2571, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Akap200^EP2072, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by CG2017^EP3503, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by cindr^EP3700, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by dom^EP2371, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Dp1^EP2422, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by EP474^EP474, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by hppy^EP2445, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by kis^EP563, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by MESR4^EP386, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by P{EP}fax^EP807, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by P{EP}wun^EP652, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by rho-6^EP2023, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by RhoGEF64C^EP3035, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Traf6^EP325, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^sev.EP has visible phenotype, non-suppressible by CRMP^supK1 (Morris et al., 2012)
Enhancer of
Statement Reference Scer\GAL4⁶⁰/Rac1^N17.Scer\UAS is an enhancer of neuroanatomy defective \| heat sensitive phenotype of N^l1N-ts1 (Song and Giniger, 2011) Scer\GAL4^twi.2PE/Rac1^N17.Scer\UAS is an enhancer of cell migration defective \| embryonic stage phenotype of pbl⁵ (van Impel et al., 2009)
NOT Enhancer of
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 is a non-enhancer of neuroanatomy defective phenotype of Scer\GAL4^ato.3.6, bsk^DN.Scer\UAS (Srahna et al., 2006)
Suppressor of
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 is a suppressor of neuroanatomy defective phenotype of Scer\GAL4^ato.3.6, btl^Scer\UAS.cDa (Srahna et al., 2006) Rac1^N17.Scer\UAS/Scer\GAL4^ato.3.6 is a suppressor of neuroanatomy defective phenotype of dsh¹ (Srahna et al., 2006) Rac1^N17.Scer\UAS/Scer\GAL4^C57 is a suppressor of neuroanatomy defective \| larval stage phenotype of Vps35^EY14200/Df(2R)ED3952 (Korolchuk et al., 2007) Rac1^N17.Scer\UAS/Scer\GAL4^elav.PLu is a suppressor of neuroanatomy defective \| larval stage phenotype of Vps35^EY14200/Df(2R)ED3952 (Korolchuk et al., 2007) Scer\GAL4^15J2/Rac1^N17.Scer\UAS is a suppressor of neuroanatomy defective \| recessive phenotype of N^l1N-ts1 (Kuzina et al., 2011)
NOT Suppressor of
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 is a non-suppressor of neuroanatomy defective phenotype of Scer\GAL4^ato.3.6, bsk^DN.Scer\UAS (Srahna et al., 2006) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Rac1^N17.Scer\UAS is a non-suppressor of decreased cell number \| germline clone \| maternal effect \| embryonic stage 15 phenotype of wun2^EP2650ex34, wun⁴⁹ (Renault et al., 2010) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Rac1^N17.Scer\UAS is a non-suppressor of decreased cell number \| germline clone \| maternal effect \| embryonic stage 16 phenotype of wun2^EP2650ex34, wun⁴⁹ (Renault et al., 2010) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Rac1^N17.Scer\UAS is a non-suppressor of increased cell death \| germline clone \| maternal effect \| embryonic stage phenotype of wun2^EP2650ex34, wun⁴⁹ (Renault et al., 2010) Scer\GAL4^NP2225/Rac1^N17.Scer\UAS is a non-suppressor of neuroanatomy defective \| embryonic stage phenotype of cv-c¹²⁶⁰ (Sato et al., 2010)
Other
Statement Reference Dcp-1^Scer\UAS.cKa, Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF has lethal phenotype (Kim et al., 2010) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu, sli² has neuroanatomy defective phenotype (Fan et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^ftz.ng, sli² has neuroanatomy defective phenotype (Fan et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU, pbl^EP3415 has lethal \| pupal stage phenotype (Raymond et al., 2004) RhoGEF64C^EP3322, Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has lethal \| pupal stage phenotype (Raymond et al., 2004)
Phenotype Manifest In
Enhanced by
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu has abdominal segmental nerve phenotype, enhanceable by plexB^Scer\UAS.cHa, Scer\GAL4^elav.PLu (Hu et al., 2001) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu has intersegmental nerve phenotype, enhanceable by plexB^Scer\UAS.cHa, Scer\GAL4^elav.PLu (Hu et al., 2001) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu has medial longitudinal fascicle phenotype, enhanceable by RhoGAP93B^Scer\UAS.cHa, Scer\GAL4^elav.PLu (Hu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has lamina phenotype, enhanceable by bur^e10/bur[+] (Long et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has medulla phenotype, enhanceable by bur^e10/bur[+] (Long et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by bchs^EP2299, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by C3G^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by CG5261^EP816, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by CG6701^EP2054, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by cpo^EP3395, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by grp^EP587, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by P{EP}EP2233, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by P{EP}EP2491, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by SNF4Aγ^EP648, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Rho1^k07903 (Fanto et al., 2000) Rac1^N17.Scer\UAS, Scer\GAL4^hs.2sev has ommatidium phenotype, enhanceable by Rho1^k07903 (Fanto et al., 2000) Rac1^N17.Scer\UAS, Scer\GAL4^sd-SG29.1 has wing phenotype, enhanceable by tum^Scer\UAS.cSa, Scer\GAL4^sd-SG29.1 (Sotillos and Campuzano, 2000) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, enhanceable by Rab11^{S25N.Scer\UAS.P\T.T:Avic\GFP-YFP}, Scer\GAL4^slbo.2.6 (Assaker et al., 2010)
NOT Enhanced by
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has axon & dorsal cluster neuron phenotype, non-enhanceable by btl^Scer\UAS.cDa, Scer\GAL4^ato.3.6 (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has axon & dorsal cluster neuron phenotype, non-enhanceable by dsh¹ (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu has abdominal segmental nerve phenotype, non-enhanceable by plexB^Bd7.Scer\UAS, Scer\GAL4^elav.PLu (Hu et al., 2001) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu has intersegmental nerve phenotype, non-enhanceable by plexB^Bd7.Scer\UAS, Scer\GAL4^elav.PLu (Hu et al., 2001) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu has medial longitudinal fascicle phenotype, non-enhanceable by Cdc42^N17.Scer\UAS, Scer\GAL4^elav.PLu (Hu et al., 2005) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Sra-1^EP3267, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Schenck et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Sra-1^unspecified (Schenck et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, non-enhanceable by Sra-1^EP3267, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Schenck et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, non-enhanceable by Sra-1^unspecified (Schenck et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Akap200^EP2072, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by CG2017^EP3503, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by cindr^EP3700, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by dom^EP2371, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Dp1^EP2422, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by EP474^EP474, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by hppy^EP2445, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by kis^EP563, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by MESR4^EP386, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by P{EP}fax^EP807, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by P{EP}wun^EP652, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by rho-6^EP2023, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by RhoGEF64C^EP3035, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Traf6^EP325, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^sev.EP has eye phenotype, non-enhanceable by CRMP^supK1 (Morris et al., 2012)
Suppressed by
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^69B has dorsal closure embryo phenotype, suppressible by th^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^69B (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^69B has embryonic/first instar larval cuticle \| dorsal phenotype, suppressible by th^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^69B (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has axon & dorsal cluster neuron phenotype, suppressible by bsk^DN.Scer\UAS, Scer\GAL4^ato.3.6 (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu, sli² has longitudinal connective phenotype, suppressible \| partially by Pak^{Scer\UAS.T:Myr-Src64B}, Scer\GAL4^elav.PLu (Fan et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu has intersegmental nerve phenotype, suppressible \| partially by plexB^dsRNA.cHa (Hu et al., 2001) Rac1^N17.Scer\UAS, Scer\GAL4^elav-C155 has intersegmental nerve phenotype, suppressible by trio^Scer\UAS.cBa, Scer\GAL4^elav-C155 (Bateman et al., 2000) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by cdi^EP3319, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mbc^Scer\UAS.cBa/Ced-12^Scer\UAS.cGa, Scer\GAL4^GMR.PU (Geisbrecht et al., 2008) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by numb^EP2455, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by poe^EP349, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by poe^EP737, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^hs.PB has dorsal closure embryo phenotype, suppressible \| partially by tkv^TAJ3 (Ricos et al., 1999) Rac1^N17.Scer\UAS, Scer\GAL4^pnr-MD237 has dorsal closure embryo phenotype, suppressible by th^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^pnr-MD237 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^pnr-MD237 has embryonic/first instar larval cuticle \| dorsal phenotype, suppressible by th^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^pnr-MD237 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by Act5C^EP1604, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by Ark[+]/Ark^CD8 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by Ark^CD4/Ark[+] (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by Ark^CD4/Ark^CD4 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by Ark^CD4/Ark^CD8 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by Ark^CD8/Ark^CD8 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by chic^Scer\UAS.cCa, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by Iap2^Scer\UAS.cWa, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by Nc^{CARD.Scer\UAS}, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by Nc^{ΔN.C-A.Scer\UAS}, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by th^EP3279, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by th^EP3308, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by th^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible \| partially by trio^Scer\UAS.cBa, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible by hop^Tum.Scer\UAS, Scer\GAL4^slbo.2.6 (Silver, 2005) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible by os^Scer\UAS.cCa, Scer\GAL4^slbo.2.6 (Silver, 2005) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, suppressible by Stat92E^Scer\UAS.cPa, Scer\GAL4^slbo.2.6 (Silver, 2005) Rac1^N17.Scer\UAS, Scer\GAL4^unspecified has embryonic epidermis \| dorsal phenotype, suppressible by Jra^Asp.hs.sev (Hou et al., 1997)
NOT suppressed by
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has axon & dorsal cluster neuron phenotype, non-suppressible by btl^Scer\UAS.cDa, Scer\GAL4^ato.3.6 (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 has axon & dorsal cluster neuron phenotype, non-suppressible by dsh¹ (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu has abdominal segmental nerve phenotype, non-suppressible by plexB^Bd7.Scer\UAS, Scer\GAL4^elav.PLu (Hu et al., 2001) Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu has intersegmental nerve phenotype, non-suppressible by plexB^Bd7.Scer\UAS, Scer\GAL4^elav.PLu (Hu et al., 2001) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Sra-1^EP3267, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Schenck et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Sra-1^unspecified (Schenck et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, non-suppressible by Sra-1^EP3267, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Schenck et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, non-suppressible by Sra-1^unspecified (Schenck et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Akap200^EP2072, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by CG2017^EP3503, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by cindr^EP3700, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by dom^EP2371, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Dp1^EP2422, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by EP474^EP474, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by hppy^EP2445, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by kis^EP563, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by MESR4^EP386, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by P{EP}fax^EP807, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by P{EP}wun^EP652, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by rho-6^EP2023, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by RhoGEF64C^EP3035, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Traf6^EP325, Scer\GAL4^GMR.PU (Raymond et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^how-24B/Scer\GAL4^how-24B has myoblast phenotype, non-suppressible by th^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^how-24B/Scer\GAL4^how-24B (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^sev.EP has eye phenotype, non-suppressible by CRMP^supK1 (Morris et al., 2012) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, non-suppressible by awd^Scer\UAS.cDa, Scer\GAL4^slbo.2.6 (Silver, 2005) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, non-suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, non-suppressible by slbo^Scer\UAS.cLa, Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004) Rac1^N17.Scer\UAS has border follicle cell phenotype, non-suppressible by Mmus\Cd8a^{Scer\UAS.T:Avic\GFP}/Scer\GAL4^slbo.2.6 (Geisbrecht and Montell, 2004)
Enhancer of
Statement Reference Rac1^N17.Scer\UAS/Scer\GAL4^ftz.ng is an enhancer of dMP2 neuron phenotype of Sos^e49 (Fritz and VanBerkum, 2002) Rac1^N17.Scer\UAS/Scer\GAL4^ftz.ng is an enhancer of pCC neuron phenotype of Sos^e49 (Fritz and VanBerkum, 2002) Rac1^N17.Scer\UAS/Scer\GAL4^ftz.ng is an enhancer of vMP2 neuron phenotype of Sos^e49 (Fritz and VanBerkum, 2002) Scer\GAL4⁶⁰/Rac1^N17.Scer\UAS is an enhancer of intersegmental nerve \| heat sensitive phenotype of N^l1N-ts1 (Song and Giniger, 2011) Scer\GAL4⁶⁰/Rac1^N17.Scer\UAS is an enhancer of intersegmental nerve branch ISNb of A1-7 \| heat sensitive phenotype of N^l1N-ts1 (Song and Giniger, 2011) Scer\GAL4^elav-C155/Rac1^N17.Scer\UAS is an enhancer of phenotype of Lar^5.5 (Kaufmann et al., 1998) Scer\GAL4^elav-C155/Rac1^N17.Scer\UAS is an enhancer of phenotype of Lar^13.2 (Kaufmann et al., 1998) Scer\GAL4^elav-C155/Rac1^N17.Scer\UAS is an enhancer of phenotype of Lar^bypass (Kaufmann et al., 1998) Scer\GAL4^twi.2PE/Rac1^N17.Scer\UAS is an enhancer of mesoderm phenotype of pbl⁵ (van Impel et al., 2009)
NOT Enhancer of
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4⁴⁷⁷ is a non-enhancer of multidendritic neuron & dendrite \| supernumerary phenotype of Scer\GAL4⁴⁷⁷, trc^{K122A.Scer\UAS.T:Zzzz\FLAG}/trc^{K122A.Scer\UAS.T:Zzzz\FLAG} (Emoto et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4⁴⁷⁷ is a non-enhancer of multidendritic neuron & dendrite phenotype of Scer\GAL4⁴⁷⁷, trc^{K122A.Scer\UAS.T:Zzzz\FLAG}/trc^{K122A.Scer\UAS.T:Zzzz\FLAG} (Emoto et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 is a non-enhancer of axon & dorsal cluster neuron phenotype of Scer\GAL4^ato.3.6, bsk^DN.Scer\UAS (Srahna et al., 2006) Rac1^N17.Scer\UAS/Scer\GAL4^ftz.ng is a non-enhancer of dMP2 neuron phenotype of robo¹ (Fritz and VanBerkum, 2002) Rac1^N17.Scer\UAS/Scer\GAL4^ftz.ng is a non-enhancer of pCC neuron phenotype of robo¹ (Fritz and VanBerkum, 2002) Rac1^N17.Scer\UAS/Scer\GAL4^ftz.ng is a non-enhancer of vMP2 neuron phenotype of robo¹ (Fritz and VanBerkum, 2002)
Suppressor of
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4⁴⁷⁷ is a suppressor of multidendritic neuron & dendrite \| supernumerary phenotype of Scer\GAL4⁴⁷⁷, trc^{K122A.Scer\UAS.T:Zzzz\FLAG}/trc^{K122A.Scer\UAS.T:Zzzz\FLAG} (Emoto et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 is a suppressor of axon & dorsal cluster neuron phenotype of Scer\GAL4^ato.3.6, btl^Scer\UAS.cDa (Srahna et al., 2006) Rac1^N17.Scer\UAS, Scer\GAL4^ftz.ng is a suppressor \| partially of dMP2 neuron phenotype of Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Fritz and VanBerkum, 2002) Rac1^N17.Scer\UAS, Scer\GAL4^ftz.ng is a suppressor \| partially of pCC neuron phenotype of Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Fritz and VanBerkum, 2002) Rac1^N17.Scer\UAS, Scer\GAL4^ftz.ng is a suppressor \| partially of vMP2 neuron phenotype of Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Fritz and VanBerkum, 2002) Rac1^N17.Scer\UAS/Scer\GAL4^ato.3.6 is a suppressor of axon & dorsal cluster neuron phenotype of dsh¹ (Srahna et al., 2006) Rac1^N17.Scer\UAS/Scer\GAL4^C57 is a suppressor of NMJ bouton phenotype of Vps35^EY14200/Df(2R)ED3952 (Korolchuk et al., 2007) Rac1^N17.Scer\UAS/Scer\GAL4^elav.PLu is a suppressor of NMJ bouton phenotype of Vps35^EY14200/Df(2R)ED3952 (Korolchuk et al., 2007) Scer\GAL4^15J2/Rac1^N17.Scer\UAS is a suppressor of pioneer neuron phenotype of N^l1N-ts1 (Kuzina et al., 2011)
NOT Suppressor of
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^332.3 is a non-suppressor of amnioserosa phenotype of Scer\GAL4^332.3, crb^Scer\UAS.cWa (Harden et al., 2002) Rac1^N17.Scer\UAS, Scer\GAL4⁴⁷⁷ is a non-suppressor of multidendritic neuron & dendrite \| supernumerary phenotype of Scer\GAL4⁴⁷⁷, trc^{K122A.Scer\UAS.T:Zzzz\FLAG}/trc^{K122A.Scer\UAS.T:Zzzz\FLAG} (Emoto et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4⁴⁷⁷ is a non-suppressor of multidendritic neuron & dendrite phenotype of Scer\GAL4⁴⁷⁷, trc^{K122A.Scer\UAS.T:Zzzz\FLAG}/trc^{K122A.Scer\UAS.T:Zzzz\FLAG} (Emoto et al., 2004) Rac1^N17.Scer\UAS, Scer\GAL4^ato.3.6 is a non-suppressor of axon & dorsal cluster neuron phenotype of Scer\GAL4^ato.3.6, bsk^DN.Scer\UAS (Srahna et al., 2006) Rac1^N17.Scer\UAS/Scer\GAL4^ftz.ng is a non-suppressor of dMP2 neuron phenotype of robo¹ (Fritz and VanBerkum, 2002) Rac1^N17.Scer\UAS/Scer\GAL4^ftz.ng is a non-suppressor of pCC neuron phenotype of robo¹ (Fritz and VanBerkum, 2002) Rac1^N17.Scer\UAS/Scer\GAL4^ftz.ng is a non-suppressor of vMP2 neuron phenotype of robo¹ (Fritz and VanBerkum, 2002) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Rac1^N17.Scer\UAS is a non-suppressor of germline cell \| germline clone \| maternal effect \| embryonic stage 15 phenotype of wun2^EP2650ex34, wun⁴⁹ (Renault et al., 2010) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/Rac1^N17.Scer\UAS is a non-suppressor of germline cell \| germline clone \| maternal effect \| embryonic stage 16 phenotype of wun2^EP2650ex34, wun⁴⁹ (Renault et al., 2010) Scer\GAL4^NP2225/Rac1^N17.Scer\UAS is a non-suppressor of dendritic tree \| embryonic stage phenotype of cv-c¹²⁶⁰ (Sato et al., 2010) Scer\GAL4^NP2225/Rac1^N17.Scer\UAS is a non-suppressor of dorsal multidendritic neuron ddaE \| embryonic stage phenotype of cv-c¹²⁶⁰ (Sato et al., 2010)
Other
Statement Reference Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu, sli² has longitudinal connective phenotype (Fan et al., 2003, Fan et al., 2003) Rac1^N17.Scer\UAS, Scer\GAL4^ftz.ng, sli² has longitudinal connective phenotype (Fan et al., 2003, Fan et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference Animals expressing dominant-negative Rac1[N17.Scer\UAS] under the control of Scer\GAL4[sev.EP] display no discernible differences in the presence or absence of homozygous CRMP[supK1]. (Morris et al., 2012) Overexpression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[15J2] suppresses the early longitudinal axon phenotype of N[l1N-ts1]. (Kuzina et al., 2011) Expression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[60], significantly increases the occurrence of ISNb bypass in N[l1N-ts1] embryos. (Song and Giniger, 2011) Co-expression of Rab11[S25N.Scer\UAS.P\T.T:Avic\GFP-YFP] with Rac1[N17.Scer\UAS] driven by Scer\GAL4[slbo.2.6] enhances the border follicle cell migration phenotype associated with Rac1[N17.Scer\UAS] expression. (Assaker et al., 2010) Co-expression of Rac1[N17.Scer\UAS] and Dcp-1[Scer\UAS.cKa] (insertion line P{UAS-Dcp-1.K}19-2) under the control of Scer\GAL4[GMR.PF] is lethal. (Kim et al., 2010) Expression of Rac1[N17.Scer\UAS] in the germline under the control of Scer\GAL4[nos.UTR.T:Hsim\VP16] does not rescue the germ cell death seen in embryos derived from females carrying wun[49] wun2[EP2650ex34] germline clones. (Renault et al., 2010) Expression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[NP2225] does not suppress the reduction in length of secondary dendritic branches which is seen in the ddaE neurons of cv-c[1260] embryos at 20-22 hours after egg laying. (Sato et al., 2010) Expression of Rac1[N17.Scer\UAS] under the control of Scer\GAL4[twi.2PE] enhances the mesodermal migration defects seen in pbl[5] homozygotes. (van Impel et al., 2009) The Scer\GAL4[GMR.PU], Rac1[N17.Scer\UAS] rough eye phenotype is suppressed by co-expression of Ced-12[Scer\UAS.cGa] and mbc[Scer\UAS.cBa]. (Geisbrecht et al., 2008) The increased bouton number at the neuromuscular junction that is seen in Vps35[EY14200]/Df(2R)ED3952 larvae is suppressed by expression of Rac1[N17.Scer\UAS] under the control of either Scer\GAL4[elav.PLu] or Scer\GAL4[C57]. (Korolchuk et al., 2007) The axonal hyperfasciculation phenotype in the lamina and medulla caused by expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^GMR.PF is enhanced by bur^e10/+. (Long et al., 2006) Coexpression of bsk^DN.Scer\UAS and Rac1^N17.Scer\UAS under the control of Scer\GAL4^ato.3.6 results in the few dorsal cluster neuron axons crossing the optic chiasma, which is the same phenotype seen as single bsk^DN.Scer\UAS expression and is opposite to that seen when only Rac1^N17.Scer\UAS is expressed. Coexpression of btl^Scer\UAS.cDa and Rac1^N17.Scer\UAS, under the control of Scer\GAL4^ato.3.6, results in the dominance of the Rac1^N17.Scer\UAS phenotype, with a large increase in the number of dorsal cluster neuron axons that cross the optic chiasm. Coexpression of btl^DN.Scer\UAS and Rac1^N17.Scer\UAS, under the control of Scer\GAL4^ato.3.6, results in all dorsal cluster neuron axons crossing the optic chiasm, instead of the majority retracting and branching within the lobula. Expression of Rac1^N17.Scer\UAS, under the control of Scer\GAL4^ato.3.6, in a dsh¹ background results in a dorsal neuron cluster phenotype similar to when Rac1^N17.Scer\UAS is expressed in a wild-type background, which is opposite to that seen in dsh¹ mutants. (Srahna et al., 2006) When RhoGAP93B^Scer\UAS.cHa is added to RhoGAP93B^Scer\UAS.cHa, Scer\GAL4^elav.PLu embryos, multiple axons exhibit ectopic crossing of the midline. On the other hand Cdc42^N17.Scer\UAS does not enhance this phenotype. (Hu et al., 2005) When RhoGAP93B^Scer\UAS.cHa is added to Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu embryos, multiple axons exhibit ectopic crossing of the midline. On the other hand Cdc42^N17.Scer\UAS does not enhance this phenotype. (Hu et al., 2005) Expression of os^Scer\UAS.cCa, hop^Tum.Scer\UAS or Stat92E^Scer\UAS.cPa suppress the border cell migration defect caused by expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6. However, expression of awd^Scer\UAS.cDa does not suppress this phenotype. (Silver, 2005) Co-expression of Cdc42^N17.Scer\UAS and Rac1^N17.Scer\UAS in the muscle, under the regulation of Scer\GAL4^Mhc.PW has no effect on gross synapse development. (Albin and Davis, 2004) The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is partially suppressed by coexpression of trio^Scer\UAS.cBa, Act5C^EP1604, th^EP3308, th^EP3279, th^{Scer\UAS.T:Ivir\HA1} or Iap2^Scer\UAS.cWa. The penetrance of the embryonic lethal phenotype caused by expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^69B or Scer\GAL4^pnr-MD237 is reduced by coexpression of th^{Scer\UAS.T:Ivir\HA1}. The embryonic cuticle phenotype (dorsal hole) caused by expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^69B or Scer\GAL4^pnr-MD237 is rescued by coexpression of th^{Scer\UAS.T:Ivir\HA1}. The dramatic defects in myoblast fusion caused by expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^how-24B are not rescued by coexpression of th^{Scer\UAS.T:Ivir\HA1}. The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is partially suppressed by coexpression of chic^Scer\UAS.cCa. The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is partially suppressed by coexpression of Nc^{ΔN.C-A.Scer\UAS} or Nc^{CARD.Scer\UAS}. The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is partially suppressed by Ark^CD4/+, Ark^CD8/+, Ark^CD4/Ark^CD4, Ark^CD8/Ark^CD8 or Ark^CD4/Ark^CD8. The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is not suppressed by coexpression of slbo^Scer\UAS.cLa. (Geisbrecht and Montell, 2004) The combination of heterozygous sli² and pan-neural overexpression of Rac1^N17.Scer\UAS (expressed under the control of Scer\GAL4^elav.PLu) leads to longitudinal axon ectopic midline crossing defects. An average of 8.3 defects are seen per animal, and an average of 75% of segments have defects. If expression of Rac1^N17.Scer\UAS is driven by Scer\GAL4^ftz.ng 4 defects are seen per animal, and an average of 36% of segments have defects. Co-expression of Pak^{Scer\UAS.T:Myr1} partially suppresses longitudinal axon ectopic midline crossing defects seen in sli²/+, Rac1^N17.Scer\UAS ; Scer\GAL4^elav.PLu animals. An average of 5 defects are seen per animal, and an average of 45% of segments have defects. (Fan et al., 2003) The addition of Rac1^N17.Scer\UAS (driven by Scer\GAL4^ftz.ng) to robo¹/+ embryos has no effect on the midline crossover phenotype seen in the pCC/MP2 pathway axons. The addition of Rac1^N17.Scer\UAS (driven by Scer\GAL4^ftz.ng) to Sos^e49 homozygous embryos enhances the midline crossover phenotype seen in the pCC/MP2 pathway axons. 91% of embryos exhibit the phenotype. An average of 8.0 crossovers are seen per embryo. The addition of chic^sand-1 to Rac1^N17.Scer\UAS has no effect on their midline crossover phenotypes in the pCC/MP2 pathway axons. (Fritz and VanBerkum, 2002) Embryos that express both crb^Scer\UAS.cWa and Rac1^N17.Scer\UAS driven by Scer\GAL4^332.3 show the premature apical cell constriction phenotype in the amnioserosa that is seen when crb^Scer\UAS.cWa expression alone is driven by Scer\GAL4^332.3. (Harden et al., 2002) The addition of plexB^Scer\UAS.cHa to Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu flies enhances the ISNb bypass phenotype seen in these flies. The addition of plexB^Scer\UAS.cHa to Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu flies has no effect on the ISNb bypass phenotype seen in these flies. The addition of plexB^Scer\UAS.cHa to Rac1^N17.Scer\UAS, Scer\GAL4^elav.PLu flies significantly suppresses the ISNb bypass phenotype seen in these flies. (Hu et al., 2001) The addition of Rho1^k07903 to Rac1^N17.Scer\UAS,Scer\GAL4^hs.2sev flies significantly enhances the eye phenotype. There is an increase in the number of achiral ommatidia. (Fanto et al., 2000) tkv^TAJ3 partially rescues the dorsal closure defect caused by expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^hs.PB. (Ricos et al., 1999) Scer\GAL4^elav-C155-mediated expression causes synergy of the Lar^5.5, Lar^13.2 and Lar^bypass full ISNb bypass phenotype. Synergistic interaction is not seen in beat-Ia²/beat-Ia³ embryos. (Kaufmann et al., 1998) The Rac1^N17.Scer\UAS dorsal open phenotype can be significantly rescued by heat induced expression of Jra^Asp.hs.sev. (Hou et al., 1997)
Xenogenetic Interactions
Statement Reference Border cell clusters expressing Rac1[N17.Scer\UAS] and Hsap\RAC1[PA.Q61L.Scer\UAS.T:Disc\RFP-mCherry,T:Zzzz\PT1] under the control of Scer\GAL4[slbo.2.6] in which Hsap\RAC1[PA.Q61L.Scer\UAS.T:Disc\RFP-mCherry,T:Zzzz\PT1] has been activated by illumination in one cell do not show forward migration. However, photoactivation of Hsap\RAC1[PA.Q61L.Scer\UAS.T:Disc\RFP-mCherry,T:Zzzz\PT1] in approximately half of the cluster results in slow forward movement. (Wang et al., 2010) The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is not suppressed by coexpression of Mmus\Cd8a^{Scer\UAS.T:Avic\GFP}. The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is not significantly suppressed by coexpression of BacA\p35^Scer\UAS.cHa. (Geisbrecht and Montell, 2004) The addition of Rac1^N17.Scer\UAS to Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng embryos partially suppresses the midline crossover phenotype seen in the pCC/MP2 pathway axons. 4.0% of embryos exhibit the phenotype. An average of 1.o crossovers are seen per embryo. (Fritz and VanBerkum, 2002)
Complementation & Rescue Data
Partially rescued by	Rac1^N17.Scer\UAS is partially rescued by Scer\GAL4^elav-C155/Rac1^Scer\UAS.cLa (Kaufmann et al., 1998) Rac1^N17.Scer\UAS is partially rescued by Scer\GAL4^slbo.2.6/Rac1^Scer\UAS.cLa (Geisbrecht and Montell, 2004)
Comments	The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is partially suppressed by coexpression of Rac1^Scer\UAS.cLa. (Geisbrecht and Montell, 2004)
Stocks ( 2 )
Bloomington	6292 y¹ w^*; P{UAS-Rac1.N17}1
Kyoto	108725 y¹ w^*; P{UAS-Rac1.N17}1
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	DRac1^N17 (Zarske and Hafen, 2003) Drac1^N17 (Paululat et al., 1999) Drac^DN (Hou et al., 1997) DRac^N17 (Medioni and Noselli, 2005) Rac1.N17 (Taniguchi et al., 2011) Rac1^N17.Scer\UAS Rac1^N17.UAS Rac1^N17 Rac^N17 (Zhu et al., 2005, Fanto et al., 2000, Stramer et al., 2005, Jang et al., 2009)
Name Synonym
Secondary FlyBase IDs
	FBal0038993
References ( 84 )

Generate a list of	All references relating to this allele ( 84 )

List References by type	Research paper ( 78 ) Supplementary material ( 4 ) Review ( 1 ) Abstract ( 1 )
Recent research papers ( 6 )
	Morris et al., 2012, Genetics 191(4): 1227--1238 Divergent Functions Through Alternative Splicing: The Drosophila CRMP Gene in Pyrimidine Metabolism, Brain, and Behavior. [FBrf0219149] Tsubouchi et al., 2012, Curr. Biol. 22(22): 2124--2134 Dendritic Filopodia, Ripped Pocket, NOMPC, and NMDARs Contribute to the Sense of Touch in Drosophila Larvae. [FBrf0219946] Kuzina et al., 2011, Development 138(9): 1839--1849 How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493] Shuai et al., 2011, J. Neurogenet. 25(1-2): 35--39 Stress Resistance Conferred by Neuronal Expression of Dominant-Negative Rac in Adult Drosophila melanogaster. [FBrf0213665] Song and Giniger, 2011, Dev. Dyn. 240(2): 324--332 Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio. [FBrf0212819] Taniguchi et al., 2011, Science 333(6040): 339--341 Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis. [FBrf0214402] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\Rac1N17.Scer\UAS

Allele Dmel\Rac1^N17.Scer\UAS