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General Information
Symbol
Dmel\Dsor1Su1
Species
D. melanogaster
Name
FlyBase ID
FBal0039033
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G9249014A

Amino acid change:

G195S | Dsor1-PA; G192S | Dsor1-PB

Reported amino acid change:

G192S

Comment:

Reported as G192S in FBrf93573. Maps to G195S in the CDS encoded by the reference sequence. The difference is due to the use of an upstream splice acceptor in an upstream intron. The annotated version is supported by full length cDNA LD41207 (GB:AY058692). The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: G192S.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Single mutant shows no mitotic figure mutant phenotype in larval brain neuroblast preparations.

Shows supernumerary pigment cells in the developing eye, due to failure of apoptosis.

The number of R7-like cells per ommatidium is slightly increased in homozygotes compared to wild-type flies.

2% of homozygous ommatidia exhibit supernumerary R7 cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Dsor1Su1, SosJC2 has visible phenotype, enhanceable by cln[+]/clnSF3-2

NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference

Dsor1Su1, SosJC2 has wing vein | ectopic phenotype, enhanceable by cln[+]/clnSF3-2

Dsor1Su1, SosJC2 has wing phenotype, enhanceable by cln[+]/clnSF3-2

Dsor1Su1, fs(1)M31901 has embryo | posterior phenotype, enhanceable by rl[+]/rl9

Dsor1Su1, fs(1)M31901 has embryo | posterior phenotype, enhanceable by rl[+]/rl10a

Suppressor of
Statement
Reference

Dsor1Su1 is a suppressor of wing phenotype of lace2/lacek05305

Dsor1Su1 is a suppressor of embryo | posterior phenotype of fs(1)M31901

Dsor1Su1 is a suppressor of wing margin phenotype of N55e11

Dsor1Su1 is a suppressor of eye phenotype of aspDD3

Dsor1Su1 is a suppressor of wing phenotype of aspDD3

Dsor1Su1 is a suppressor of eye phenotype of asp1

Dsor1Su1 is a suppressor of wing phenotype of asp1

Dsor1Su1 is a suppressor of eye phenotype of rprGMR.PW

Dsor1Su1 is a suppressor of eye disc phenotype of hidGMR.PG/WGMR.PG

Dsor1Su1 is a suppressor of phenotype of Raf1

Dsor1Su1 is a suppressor of phenotype of tor4

Dsor1Su1 is a suppressor of head phenotype of Egfrf7

Dsor1Su1 is a suppressor of phenotype of sev6

Dsor1Su1 is a suppressor of phenotype of aoshs.PSa

Other
Additional Comments
Genetic Interactions
Statement
Reference

Dsor1Su1/Y ; SosJC2/+ flies have extra wing veins. This phenotype is enhanced by one copy of clnSF3-2.

Strongly suppresses the lacek05305/lace2 phenotype.

Embryos derived from homozygous fs(1)M31901 females fail to develop structures posterior to the seventh abdominal segment as well as anterior-most structures, including the head skeleton. The posterior defect is significantly suppressed if the female is also carrying one copy of Dsor1Su1; an eighth abdominal segment is formed. This suppression is significantly reduced if the females are also carrying one copy of rl9, rl10a or Df(2R)rl10b. Enhances the tor11D phenotype; considerable numbers of embryos laid by females heterozygous for Dsor1Su1 and tor11D fail to hatch at 28oC.

Suppresses the wing margin defect of N55e11/+ flies.

Suppresses the morphological defects and sterility of asp1/aspDD3 mutants. Survival of embryos is increased, fewer have no nuclei. The asp1; Dsor1Su1 double mutant shows reduction in the frequency of aneuploid and polyploid figures compared to asp1 single mutants.

Suppresses the eye reduction phenotype caused by rprGMR.PW. Suppresses the eye reduction phenotype caused by WGMR.PG.

Suppresses the reduced-eye and increased cell death phenotypes of WGMR.PG.

Completely suppresses the eye phenotype of phl1 hemizygotes. SosJC2 heterozygotes also hemizygous for Dsor1Su1 have 2.62 +/- 0.83 R7-like cells per ommatidium. Partly suppresses the sev6 phenotype; flies hemizygous for sev6 and Dsor1Su1 have an R7 photoreceptor cell in 28.7% of ommatidia. Partly suppresses the maternal tor4 phenotype; 80.3% of embryos derived from tor4 Dsor1Su1 females have an A8 segment. Does not significantly alter the EgfrE3 eye phenotype. Partly suppresses the Egfrf7 phenotype.

Dsor1Su1; argos152 flies exhibit extra R7-like cells in 25% of ommatidia. Suppression of P{hs-argos.S} rough eye phenotype is dose-dependent.

Suppression of eclosion defects and rough eye phenotype of phl1, increase the proliferation rate of phlraf-1 and rescue defects associated with other phl mutations (alleles unspecified).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Induced on: phl1.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Dsor1Su1
Name Synonyms
Secondary FlyBase IDs
    References (16)