Allele Dmel\Su(H)^IB115

General Information
Symbol	Dmel\Su(H)^IB115	Species	D. melanogaster
Name		FlyBase ID	FBal0039061
Feature type	allele	Associated gene	Dmel\Su(H)

Map ( GBrowse )
Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Schweisguth and Posakony, 1992, Schweisguth et al., 1994, Couso et al., 1995, Gho et al., 1996) loss of function allele (Matsuno et al., 1997)
Mutagen	ethyl methanesulfonate (Furukawa et al., 1992, Ashburner et al., 1999.10.12)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:15,041,122..15,041,122 pr_change=K138@ na_change=A15041122T (Furukawa et al., 1992)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nonsense mutation in codon 138. (Schweisguth et al., 1994) Nucleotide substitution: A1226T. Amino acid replacement: K94@. (Furukawa et al., 1992)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (Schweisguth et al., 1994) lethal \| pupal stage \| recessive (Schweisguth and Posakony, 1992, Song et al., 2009) memory defective \| adult stage \| dominant (Song et al., 2009)
Phenotype Manifest In
	embryonic/larval lymph gland (with Su(H)¹) (Tokusumi et al., 2010) eye-antennal disc (Schweisguth and Posakony, 1992) plasmatocyte (with Su(H)¹) (Tokusumi et al., 2010) sensory mother cell (Schweisguth and Posakony, 1992) wing disc (Schweisguth and Posakony, 1992)
Detailed Description
	Statement Reference The number of corpora cardiaca cells is normal in mutant embryos. (Park et al., 2011) Su(H)[1]/Su(H)[IB115] mutant tissues exhibit a loss of ptc-positive prohemocytes and the overproduction of differentiated plasmatocytes. By contrast, an increase is not observed in the crystal cell population in Su(H)[1]/Su(H)[IB115] mutant lymph glands. (Tokusumi et al., 2010) Homozygotes are lethal during pupal development. Heterozygous flies carrying out 10 training sessions to test memory of odours display a lower 24 hour memory in spaced training (rest periods between tasks) compared to control flies. (Song et al., 2009) No effect on the faf eye phenotype. (Huang and Fischer-Vize, 1996) Su(H)⁸/Su(H)^IB115 wings are reduced to stumps. (Couso et al., 1995) Lethality during the first day of pupal development. Supernumerary cells stained in mutant imaginal discs have adopted a sensory organ precursor (SOP) fate instead of the epidermal fate they would normally express. The excess SOPs arise from the proneural clusters of potential precursor cels that appear in the imaginal discs during the development of wild type bristles. The wing pouch region of the wing imaginal disc and the retinal field of the eye-antennal imaginal disc are dramatically reduced. Identical phenotype is seen when transheterozygous with Df(2L)TE35BC-24, Su(H)¹, Su(H)² or Su(H)⁸. (Schweisguth and Posakony, 1992)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Su(H)[+]/Su(H)^IB115 is an enhancer of visible \| dominant phenotype of N^Mcd1 (Ramain et al., 2001) Su(H)[+]/Su(H)^IB115 is an enhancer of visible \| dominant phenotype of N^Mcd5 (Ramain et al., 2001)
Suppressor of
Statement Reference Su(H)^IB115 is a suppressor of visible phenotype of N^act.sev (Matsuno et al., 1997)
Other
Statement Reference N^Mcd5, Su(H)^IB115 has visible \| somatic clone phenotype (Ramain et al., 2001, Ramain et al., 2001)
Phenotype Manifest In
Enhancer of
Statement Reference Su(H)[+]/Su(H)^IB115 is an enhancer of adult thorax & microchaeta phenotype of N^Mcd1 (Ramain et al., 2001) Su(H)[+]/Su(H)^IB115 is an enhancer of adult thorax & microchaeta phenotype of N^Mcd5 (Ramain et al., 2001)
Suppressor of
Statement Reference Su(H)^IB115 is a suppressor of phenotype of H¹ (Furukawa et al., 1992) Su(H)^IB115 is a suppressor of photoreceptor cell R3 phenotype of N^act.sev (Matsuno et al., 1997) Su(H)^IB115 is a suppressor of photoreceptor cell R4 phenotype of N^act.sev (Matsuno et al., 1997) Su(H)^IB115 is a suppressor of photoreceptor cell R7 phenotype of N^act.sev (Matsuno et al., 1997)
Other
Statement Reference N^Mcd5, Su(H)^IB115 has microchaeta \| somatic clone phenotype (Ramain et al., 2001, Ramain et al., 2001)
Additional Comments
Genetic Interactions
Statement Reference Su(H)^IB115 dominantly enhances the loss of microchaetae seen in N^Mcd1, N^Mcd5 or N^Mcd8 heterozygotes, reducing the number of microchaetae per heminotum to 64.00 +/- 1.84, 69.92 +/- 1.86 or 79.67 +/- 1.40 respectively. (Ramain et al., 2001) Mutation has no detectable effect on the rough eye phenotypes of N^ANK.sev. (Matsuno et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Su(H)^IB115 is rescued by Su(H)^+t6.0 (Schweisguth et al., 1994) Su(H)^IB115 is rescued by Su(H)^F (Schweisguth et al., 1994)
Comments	Neurogenic and lethal phenotype can be fully rescued by Su(H)^+t6.0. (Schweisguth et al., 1994)
Stocks ( 1 )
Bloomington	26661 Su(H)^IB115 fzy¹ cn¹ bw¹ sp¹/CyO
Notes on Origin
Discoverer

Comments
	Has no effect the phenotype of N^l1N-ts1/N^fa-g62. (Fortini and Artavanis-Tsakonas, 1994)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Su(H)^IB115 (Tokusumi et al., 2010, Song et al., 2009, Park et al., 2011)
Name Synonym
Secondary FlyBase IDs
	FBal0034029
References ( 15 )
Research paper	Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Tokusumi et al., 2010, Development 137(21): 3561--3568 Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis. [FBrf0212074] Song et al., 2009, J. Neurogenet. 23(4): 405--411 Suppressor of Hairless Is Required for Long-Term Memory Formation in Drosophila. [FBrf0210464] Ramain et al., 2001, Curr. Biol. 11(22): 1729--1738 Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. [FBrf0141440] Matsuno et al., 1997, Development 124(21): 4265--4273 Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements. [FBrf0099385] Gho et al., 1996, Development 122(6): 1673--1682 Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. [FBrf0088148] Huang and Fischer-Vize, 1996, Development 122(10): 3207--3216 Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease. [FBrf0090618] Leviten and Posakony, 1996, Dev. Biol. 176(2): 264--283 Gain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development. [FBrf0088401] Verheyen et al., 1996, Genetics 144(3): 1127--1141 Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. [FBrf0090844] Couso et al., 1995, Curr. Biol. 5(12): 1437--1448 Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila. [FBrf0084908] Fortini and Artavanis-Tsakonas, 1994, Cell 79(2): 273--282 The suppressor of Hairless protein participates in Notch receptor signaling. [FBrf0076038] Schweisguth et al., 1994, Dev. Biol. 166(2): 812--814 The sequence similarity of the Drosophila Suppressor of Hairless protein to the integrase domain has no functional significance in vivo. [FBrf0079374] Furukawa et al., 1992, Cell 69: 1191--1197 The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. [FBrf0055544] Schweisguth and Posakony, 1992, Cell 69: 1199--1212 Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. [FBrf0055545]
Personal communication to FlyBase	Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153]

Allele Dmel\Su(H)IB115

Allele Dmel\Su(H)^IB115