FlyBase Allele Report: Dmel\Su(dx)[sp]

General Information

Symbol

Dmel\Su(dx)^sp

Species

D. melanogaster

Name

spontaneous

FlyBase ID

FBal0039064

Feature type

allele

Associated gene

Dmel\Su(dx)

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Busseau et al., 1994)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Cornell et al., 1999)

Description

Seven codon deletion within the protein coding sequence. The deletion preserves the reading frame and leaves the remainder of the protein intact.

(Cornell et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:2,042,965..2,042,985 [+]

Comment:

A 7 amino acid deletion.

(Cornell et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | oogenesis

(Wilkin et al., 2024)

visible | adult stage (with Su(dx)^JD)

(Wilkin et al., 2024)

visible | adult stage | recessive

(Wilkin et al., 2024)

visible | heat sensitive

(Cornell et al., 1999, Fostier et al., 1998)

Phenotype Manifest In

crossvein | heat sensitive

(Fostier et al., 1998)

egg chamber

(Wilkin et al., 2024)

egg chamber (with Su(dx)⁵⁶)

(Wilkin et al., 2024)

female germline 16-cell cyst | increased number

(Wilkin et al., 2024)

follicle cell & nucleus | somatic clone

(Wilkin et al., 2004)

follicle cell | somatic clone

(Wilkin et al., 2004)

ovariole

(Wilkin et al., 2024)

ovariole (with Su(dx)⁵⁶)

(Wilkin et al., 2024)

stalk follicle cell | decreased number

(Wilkin et al., 2024)

wing

(Wilkin et al., 2024)

wing (with Su(dx)^JD)

(Wilkin et al., 2024)

wing vein

(Wilkin et al., 2024)

wing vein (with Su(dx)^JD)

(Wilkin et al., 2024)

wing vein | heat sensitive

(Cornell et al., 1999, Fostier et al., 1998)

wing vein L2 | heat sensitive

(Fostier et al., 1998)

wing vein L4 | heat sensitive

(Fostier et al., 1998)

wing vein L5 | heat sensitive

(Fostier et al., 1998)

Detailed Description

Statement

Reference

Cell density is reduced in homozygous follicle cell clones and the nuclei are enlarged.

(Wilkin et al., 2004)

Temperature sensitive wing-vein gap phenotype.

(Cornell et al., 1999)

Wing veins are wild type at 25^oC. At 29^oC a recessive wing vein gap phenotype appears, most often in L4 and L5, frequently in L2 but never in L3. At 29^oC heterozygotes with Su(dx)⁴, Su(dx)⁵⁶ or Df(2L)Su(dx)-7 show a recessive wing vein gap phenotype. At 25^oC the same combination has intact longitudinal veins but forked or incomplete crossveins. Temperature-shift analysis revealed a temperature sensitive period for the wing vein phenotype between 20 and 28 hours APF at 25^oC.

(Fostier et al., 1998)

Homozygotes and heterozygotes are phenotypically wild type.

(Busseau et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(dx)^sp is an enhancer of visible phenotype of N^Ax-E2

(Fostier et al., 1998)

Suppressor of

Statement

Reference

Su(dx)^sp is a suppressor | partially of visible | adult stage phenotype of N^nd-1

(Wilkin et al., 2024)

Other

Statement

Reference

Su(dx)^sp, dx¹⁵² has visible | adult stage phenotype

(Wilkin et al., 2024)

N^nd-1, Su(dx)^sp has visible | adult stage phenotype

(Wilkin et al., 2024)

N^nd-1, Su(dx)^sp/Su(dx)[+], dx^S1M has lethal phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp/Su(dx)³², dx^S1M has visible phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp has visible | recessive phenotype

(Cornell et al., 1999)

N^Ax-E2, Su(dx)^sp has partially lethal - majority die phenotype

(Fostier et al., 1998)

N^unspecified, Su(dx)^sp has partially lethal - majority die phenotype

(Fostier et al., 1998)

N^Ax-E2, Su(dx)^sp, dx^ENU has lethal phenotype

(Busseau et al., 1994)

Phenotype Manifest In

Enhanced by

Statement

Reference

Su(dx)^sp/Su(dx)⁵⁶ has egg chamber phenotype, enhanceable by N^55e11

(Wilkin et al., 2024)

Su(dx)^sp/Su(dx)⁵⁶ has ovariole phenotype, enhanceable by N^55e11

(Wilkin et al., 2024)

Enhancer of

Statement

Reference

Su(dx)^sp is an enhancer of tarsal segment & joint | ectopic phenotype of N^nd-1

(Mazaleyrat et al., 2003)

Su(dx)^sp is an enhancer of tarsal segment 4 & joint | ectopic phenotype of N^nd-1

(Mazaleyrat et al., 2003)

Su(dx)^sp is an enhancer of wing vein L5 phenotype of H¹

(Fostier et al., 1998)

Su(dx)^sp is an enhancer of macrochaeta phenotype of H¹

(Fostier et al., 1998)

Su(dx)^sp is an enhancer of microchaeta phenotype of H¹

(Fostier et al., 1998)

Su(dx)^sp is an enhancer of wing vein phenotype of N^Ax-E2

(Fostier et al., 1998)

Su(dx)^sp is an enhancer of wing vein phenotype of E(spl)mβ-HLH^UAS.cdCa, Scer\GAL4^Bx-MS1096

(Fostier et al., 1998)

Su(dx)^sp is an enhancer of macrochaeta phenotype of E(spl)mβ-HLH^UAS.cdCa, Scer\GAL4^Bx-MS1096

(Fostier et al., 1998)

Su(dx)^sp is an enhancer of microchaeta phenotype of E(spl)mβ-HLH^UAS.cdCa, Scer\GAL4^Bx-MS1096

(Fostier et al., 1998)

NOT Enhancer of

Statement

Reference

Su(dx)^sp/Su(dx)[+] is a non-enhancer of wing phenotype of pyd^tam/pyd^ex147

(Djiane et al., 2011)

Su(dx)^sp/Df(2L)Exel6006 is a non-enhancer of wing phenotype of pyd^tam/pyd^ex147

(Djiane et al., 2011)

Suppressor of

Statement

Reference

Su(dx)^sp is a suppressor of wing margin phenotype of N^nd-1

(Wilkin et al., 2024)

Su(dx)^sp is a suppressor of wing vein phenotype of Delta¹⁷¹

(Fostier et al., 1998)

Su(dx)^sp is a suppressor of wing vein phenotype of dx^S1M

(Fostier et al., 1998)

Su(dx)^sp is a suppressor of wing phenotype of dx^S1M

(Fostier et al., 1998)

Su(dx)^sp is a suppressor of wing vein phenotype of dx^ENU

(Fostier et al., 1998)

Su(dx)^sp is a suppressor of wing phenotype of dx^ENU

(Fostier et al., 1998)

Su(dx)^sp/Su(dx)[+] is a suppressor of wing phenotype of dx¹

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of eye phenotype of dx^P

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of ocellus phenotype of dx^P

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of wing phenotype of dx^S1M

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of eye phenotype of dx^S1M

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of ocellus phenotype of dx^S1M

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of eye phenotype of dx¹

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of ocellus phenotype of dx¹

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of wing phenotype of dx^ENU

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of eye phenotype of dx^ENU

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of ocellus phenotype of dx^ENU

(Busseau et al., 1994)

Su(dx)^sp/Su(dx)[+] is a suppressor of wing phenotype of dx^P

(Busseau et al., 1994)

Other

Statement

Reference

Su(dx)^sp, dx¹⁵² has leg joint | ectopic | adult stage phenotype

(Wilkin et al., 2024)

N^nd-1, Su(dx)^sp has wing vein phenotype

(Wilkin et al., 2024)

N^nd-1, Su(dx)^sp has tarsal segment 3 & joint | ectopic phenotype

(Mazaleyrat et al., 2003)

N^nd-1, Su(dx)^sp has wing vein L3 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp has wing vein L4 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp/Su(dx)³², dx^S1M has wing vein phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp has wing vein L2 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp has wing vein L5 phenotype

(Cornell et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Wings from pyd^ex147/pyd^tam flies are broader compared to control wings, and this phenotype is not modified in a Su(dx)^sp/Df(2L)Exel6006 background.

Wings from pyd^ex147/pyd^tam flies are broader compared to control wings, and this phenotype is not modified in a Su(dx)^sp/+ background.

(Djiane et al., 2011)

N^nd-1/Y, Su(dx)^sp have extra, reversed polarity joints in tarsal segments three and four.

(Mazaleyrat et al., 2003)

N^nd-1/+, Su(dx)^sp/Su(dx)³² shows a longitudinal vein gap phenotype.

(Cornell et al., 1999)

Suppression of dx^ENU and dx^S1M is stronger than for Df(2L)Su(dx)-7. Dominantly suppresses the wing notching phenotype of a notchoid allele of N, at the same time as enhancing a wing vein gap phenotype. This combination is near lethal when homozygous, with escapers showing further enhancement of wing vein gaps and held out and down curved wings. Heterozygous combinations of Su(dx)^sp, Su(dx)⁴, Su(dx)⁵⁶ and Df(2L)Su(dx)-7 weakly enhance the wing vein phenotype of N^Ax-E2, but homozygous Su(dx)^sp at 25^oC strongly enhances the phenotype. The combination is poorly viable but escapers show further enhancement of wing vein gaps and held out and down curved wings. Enhances the wing vein gap phenotype and bristle phenotype of H¹. Suppression of Dl¹⁷¹ by Su(dx)^sp acts particularly at the distal ends of the veins. Su(dx)^sp has no effect on the wing margin phenotype of Ser¹. Enhances the wing gap and bristle phenotypes of Scer\GAL4^Bx-MS1096, HLHmβ^{Scer\UAS.cdCa} flies.

(Fostier et al., 1998)

Triple homozygotes with N^Ax-E2, dx^ENU are inviable. Dominantly suppresses the mutant wing eye and ocelli phenotypes of dx^ENU, dx¹, dx^P and dx^S1M.

(Busseau et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Su(dx)⁵⁶

(Wilkin et al., 2024)

Su(dx)³²

(Cornell et al., 1999)

Su(dx)⁵⁶

(Fostier et al., 1998)