FlyBase Allele Report: Dmel\Src42A[Su(Raf)1-1]

General Information

Symbol

Dmel\Src42A^Su(Raf)1-1

Species

D. melanogaster

Name

FlyBase ID

FBal0039065

Feature type

allele

Associated gene

Dmel\Src42A

Associated Insertion(s)

Carried in Construct

Also Known As

Src42A^Su(Raf)1

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lu and Li, 1999, Lu et al., 1994)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal | recessive

(Zhang et al., 1999)

lethal - all die during embryonic stage | recessive

(Lu and Li, 1999)

some die during embryonic stage | recessive

(Lu and Li, 1999)

Phenotype Manifest In

embryo | dorsal closure stage

(Lu and Li, 1999)

embryonic/larval tracheal system

(Lu and Li, 1999)

Detailed Description

Statement

Reference

Homozygous clones in the eye do not produce extra photoreceptor cells. Src42A^Su(phl)1-1/Df(2R)nap9 animals show defects in head involution, tail morphology and tracheal necrosis.

(Lu and Li, 1999)

Heterozygotes are viable with no obvious phenotype.

(Zhang et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Src42A^Su(Raf)1-1 is a suppressor of lethal phenotype of Raf¹

(Zhang and Lu, 2000, Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor of visible | recessive phenotype of Dsor1^XS520

(Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor of visible | recessive phenotype of Sos^x122

(Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor of visible | recessive phenotype of Raf¹

(Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor of visible | recessive phenotype of Sos^AM14

(Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor of lethal | recessive phenotype of Raf¹

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 is a suppressor of lethal | pupal stage | heat sensitive phenotype of Raf¹²

(Lu et al., 1994)

Src42A^Su(Raf)1-1 is a suppressor of lethal phenotype of Dsor1^LH110

(Lu et al., 1994)

NOT Suppressor of

Statement

Reference

Src42A^Su(Raf)1-1 is a non-suppressor of lethal | pupal stage phenotype of Csk^j1D8/Csk^S030003

(Read et al., 2004)

cnk^sag13L/Src42A^Su(Raf)1-1 is a non-suppressor of lethal phenotype of Raf¹

(Zhang and Lu, 2000)

Src42A^Su(Raf)1-1/cnk^sag32-3 is a non-suppressor of lethal phenotype of Raf¹

(Zhang and Lu, 2000)

Other

Statement

Reference

Ras85D^V12.sev, Src42A^Su(Raf)1-1 has lethal | dominant | pupal stage phenotype

(Lu and Li, 1999)

Src42A^Su(Raf)1-1, Raf¹ has viable phenotype

(Lu and Li, 1999, Zhang et al., 1999)

Src42A^Su(Raf)1-1, Raf::tor^13D.hs.sev has lethal | dominant | pupal stage phenotype

(Lu and Li, 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr^unspecified

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr^f24

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by S[+]/S^IIN

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by rho^7M43/rho[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by 14-3-3ζ⁰⁷¹⁰³/14-3-3zeta[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by bowl⁸⁵/bowl[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by bowl^2-17-29-5/bowl[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(tor)2-164-14[+]/Su(tor)2-164-14^2-164-14

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(tor)278-22[+]/Su(tor)278-22^278-22

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(tor)2-113-31^2-113-31/Su(tor)2-113-31[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(tor)2-68-20[+]/Su(tor)2-68-20^2-68-20

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(tor)2-321[+]/Su(tor)2-321¹

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by rl[+]/rl¹⁰

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(H)⁸/Su(H)[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Ser^rev6-1/Ser[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr^40-6

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr^30-1

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr^9-2

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr^24-1

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr^26-3

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr⁴

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr⁵

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr⁶

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by drk[+]/drk^ΔP24

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr⁹

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr¹⁵

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Egfr[+]/Egfr²⁷

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by rl^41-1/rl[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by rl[+]/rl^A3-2

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by cnk^16-2/sag[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by cnk⁸/sag[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by sag[+]/cnk¹⁶

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by cnk¹⁸/sag[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by cnk³³/sag[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Sos^x122/Sos[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by cnk^sag13L/sag[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(SuRaf1)IV^A7-2/Su(SuRaf1)IV[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(SuRaf1)IV⁴/Su(SuRaf1)IV[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(SuRaf1)19-2[+]/Su(SuRaf1)19-2^19-2

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(SuRaf1)A2-1[+]/Su(SuRaf1)A2-1^A2-1

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(SuRaf1)1[+]/Su(SuRaf1)1¹

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(SuRaf1)2[+]/Su(SuRaf1)2²

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(SuRaf1)10[+]/Su(SuRaf1)10¹⁰

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(SuRaf1)11¹¹/Su(SuRaf1)11[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Su(SuRaf1)12[+]/Su(SuRaf1)12¹²

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Sos[+]/Sos^34Ea-6

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Ras85D^e2F/Ras85D[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Df(2R)M41A10

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Df(2L)ast2

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Ras85D^e1B/Ras85D[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by Ras85D⁰⁵⁷⁰³/Ras85D[+]

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, suppressible by spi[+]/spi^SC1

(Zhang et al., 1999)

NOT suppressed by

Statement

Reference

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by Ras85D^ΔC40B

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by spi¹

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by vn^ddd-4

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by bowl^2-60-20

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by Su(tor)2-187-2^2-187-2

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by Su(tor)2-280-28^2-280-28

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by Su(tor)2-341-39^2-341-39

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by Su(tor)2-28-23^2-28-23

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by bib⁷

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by neur¹¹

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by mam²¹

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by tkv⁷

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by Mad¹²

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by rl^13R

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by put¹³⁵

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by Df(3R)Espl4

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 has phenotype, non-suppressible by Df(3R)Dl-M2

(Zhang et al., 1999)

Suppressor of

Statement

Reference

Src42A^Su(Raf)1-1 is a suppressor of eye phenotype of Dsor1^XS520

(Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor of eye phenotype of Sos^x122

(Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor of eye phenotype of Raf¹

(Lu and Li, 1999, Lu et al., 1994)

Src42A^Su(Raf)1-1 is a suppressor of ommatidium phenotype of Raf¹

(Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor of photoreceptor cell R7 phenotype of Raf¹

(Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor of eye phenotype of Sos^AM14

(Lu and Li, 1999)

Src42A^Su(Raf)1-1 is a suppressor | partially of photoreceptor cell R7 phenotype of Raf¹

(Zhang et al., 1999)

Src42A^Su(Raf)1-1 is a suppressor | partially of ommatidium phenotype of Raf¹

(Zhang et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Suppresses the lethality of phl¹. Lethality at the pupal stage is seen in Src42A^Su(phl)1-1 Ras85D^V12.sev or Src42A^Su(phl)1-1 phl::tor^13D.hs.sev double heterozygotes. The rough eye phenotype of hemizygous phl¹ pharate adult males is also suppressed by Src42A^Su(phl)1-1. Dominantly suppresses the rough eye phenotype of Dsor1^XS520 and Sos^x122/Sos^AM14.

(Lu and Li, 1999)

Suppresses the phl¹ phenotype; phl¹/Y flies die, whereas phl¹/Y ; Src42A^Su(phl)1-1/+ flies are viable and fertile. phl¹/Y pharate adults have rough eyes and the R7 cell is missing in 88% of ommatidia. Rescued phl¹/Y ; Src42A^Su(phl)1-1/+ flies have rough eyes and the R7 cell is missing in 36% of ommatidia. The ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies is dominantly suppressed by Egfr^unspecified, Egfr^f24, rl¹⁰, Df(2R)M41A10, drk^ΔP24, Sos^x122, Sos^34Ea-6, Ras85D^e2F, Ras85D^e1B, Ras85D⁰⁵⁷⁰³, spi^SC1, Df(2L)ast2, S^IIN, rho^7M43, 14-3-3ζ⁰⁷¹⁰³, bowl⁸⁵, bowl^2-17-29-5, Su(tor)2-164-14^2-164-14, Su(tor)278-22^278-22, Su(tor)2-113-31^2-113-31, Su(tor)2-68-20^2-68-20, Su(tor)2-321¹, Su(H)⁸, Df(3R)Dl-M2, Ser^rev6-1, Egfr^40-6, Egfr^30-1, Egfr^9-2, Egfr^24-1, Egfr^26-3, Egfr⁴, Egfr⁵, Egfr⁶, Egfr⁹, Egfr¹⁵, Egfr²⁷, rl^41-1, rl^A3-2, rl^21-1, rl^Z3, rl^Z7, rl¹⁹, sag^32-3, sag^A4-2, sag^16-2, sag⁸, sag¹⁶, sag¹⁸, sag³³, sag^13L, Su(SuRaf1)IV^A7-2, Su(SuRaf1)IV⁴, Su(SuRaf1)19-2^19-2, Su(SuRaf1)A2-1^A2-1, Su(SuRaf1)1¹, Su(SuRaf1)2², Su(SuRaf1)10¹⁰, Su(SuRaf1)11¹¹ or Su(SuRaf1)12¹². The ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies is not suppressed by Ras85D^ΔC40B, spi¹, vn^ddd-4, bowl^2-60-20, Su(tor)2-187-2^2-187-2, Su(tor)2-280-28^2-280-28, Su(tor)2-341-39^2-341-39, Su(tor)2-28-23^2-28-23, bib⁷, Df(3R)Espl4, neur¹¹, mam²¹, tkv⁷, Mad¹², rl^13R or put¹³⁵.

(Zhang et al., 1999)

One copy is able to rescue the lethality of phl¹, phl¹² and Dsor1^LH110 homozygotes, partially rescue the eye defect of phl¹ male hemizygotes and allow phl¹ homozygous females to produce few eggs with variable phenotype, fused or normal dorsal appendages.

(Lu et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Src42A^k10115

(Lu and Li, 1999)

Src42A^k10108

(Lu and Li, 1999)

Src42A^18-2

(Lu and Li, 1999)