Allele Dmel\Src42A^Su(phl)1-1

General Information
Symbol	Dmel\Src42A^Su(phl)1-1	Species	D. melanogaster
Name		FlyBase ID	FBal0039065
Feature type	allele	Associated gene	Dmel\Src42A
Also Known As	Src42A^Su(Raf)1

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Lu et al., 1994, Lu and Li, 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Lu and Li, 1999) lethal \| recessive (Zhang et al., 1999)
Phenotype Manifest In
	dorsal closure embryo (Lu and Li, 1999) embryonic/larval tracheal system (Lu and Li, 1999)
Detailed Description
	Statement Reference Homozygous clones in the eye do not produce extra photoreceptor cells. Src42A^Su(phl)1-1/Df(2R)nap9 animals show defects in head involution, tail morphology and tracheal necrosis. (Lu and Li, 1999) Heterozygotes are viable with no obvious phenotype. (Zhang et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Src42A^Su(phl)1-1 is a suppressor of lethal \| pupal stage \| heat sensitive phenotype of phl¹² (Lu et al., 1994) Src42A^Su(phl)1-1 is a suppressor of lethal \| recessive phenotype of phl¹ (Zhang et al., 1999) Src42A^Su(phl)1-1 is a suppressor of lethal phenotype of Dsor1^LH110 (Lu et al., 1994) Src42A^Su(phl)1-1 is a suppressor of lethal phenotype of phl¹ (Lu and Li, 1999, Zhang and Lu, 2000) Src42A^Su(phl)1-1 is a suppressor of visible \| recessive phenotype of Dsor1^XS520 (Lu and Li, 1999) Src42A^Su(phl)1-1 is a suppressor of visible \| recessive phenotype of phl¹ (Lu and Li, 1999) Src42A^Su(phl)1-1 is a suppressor of visible \| recessive phenotype of Sos^AM14 (Lu and Li, 1999) Src42A^Su(phl)1-1 is a suppressor of visible \| recessive phenotype of Sos^x122 (Lu and Li, 1999)
NOT Suppressor of
Statement Reference sag^13L/Src42A^Su(phl)1-1 is a non-suppressor of lethal phenotype of phl¹ (Zhang and Lu, 2000) Src42A^Su(phl)1-1/sag^32-3 is a non-suppressor of lethal phenotype of phl¹ (Zhang and Lu, 2000) Src42A^Su(phl)1-1 is a non-suppressor of lethal \| pupal stage phenotype of Csk^j1D8/Csk^S030003 (Read et al., 2004)
Other
Statement Reference Ras85D^V12.sev, Src42A^Su(phl)1-1 has lethal \| dominant \| pupal stage phenotype (Lu and Li, 1999, Lu and Li, 1999) Src42A^Su(phl)1-1, phl::tor^13D.hs.sev has lethal \| dominant \| pupal stage phenotype (Lu and Li, 1999, Lu and Li, 1999) Src42A^Su(phl)1-1, phl¹ has viable phenotype (Lu and Li, 1999, Zhang et al., 1999)
Phenotype Manifest In
Suppressed by
Statement Reference Src42A^Su(phl)1-1 has phenotype, suppressible by 14-3-3ζ⁰⁷¹⁰³/14-3-3zeta[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by bowl^2-17-29-5/bowl[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by bowl⁸⁵/bowl[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Df(2L)ast2 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Df(2R)M41A10 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by drk[+]/drk^ΔP24 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr⁴ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr⁵ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr⁶ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr^9-2 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr⁹ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr¹⁵ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr^24-1 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr^26-3 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr²⁷ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr^30-1 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr^40-6 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr^f24 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Egfr[+]/Egfr^unspecified (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Ras85D⁰⁵⁷⁰³/Ras85D[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Ras85D^e1B/Ras85D[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Ras85D^e2F/Ras85D[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by rho^7M43/rho[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by rl[+]/rl¹⁰ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by rl[+]/rl^A3-2 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by rl^41-1/rl[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by S[+]/S^IIN (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by sag[+]/sag¹⁶ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by sag⁸/sag[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by sag^13L/sag[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by sag^16-2/sag[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by sag¹⁸/sag[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by sag³³/sag[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Ser^rev6-1/Ser[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Sos[+]/Sos^34Ea-6 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Sos^x122/Sos[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by spi[+]/spi^SC1 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(H)⁸/Su(H)[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(SuRaf1)1[+]/Su(SuRaf1)1¹ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(SuRaf1)2[+]/Su(SuRaf1)2² (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(SuRaf1)10[+]/Su(SuRaf1)10¹⁰ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(SuRaf1)11¹¹/Su(SuRaf1)11[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(SuRaf1)12[+]/Su(SuRaf1)12¹² (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(SuRaf1)19-2[+]/Su(SuRaf1)19-2^19-2 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(SuRaf1)A2-1[+]/Su(SuRaf1)A2-1^A2-1 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(SuRaf1)IV⁴/Su(SuRaf1)IV[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(SuRaf1)IV^A7-2/Su(SuRaf1)IV[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(tor)2-68-20[+]/Su(tor)2-68-20^2-68-20 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(tor)2-113-31^2-113-31/Su(tor)2-113-31[+] (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(tor)2-164-14[+]/Su(tor)2-164-14^2-164-14 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(tor)2-321[+]/Su(tor)2-321¹ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, suppressible by Su(tor)278-22[+]/Su(tor)278-22^278-22 (Zhang et al., 1999)
NOT suppressed by
Statement Reference Src42A^Su(phl)1-1 has phenotype, non-suppressible by bib⁷ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by bowl^2-60-20 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by Df(3R)Dl-M2 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by Df(3R)Espl4 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by Mad¹² (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by mam²¹ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by neur¹¹ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by put¹³⁵ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by Ras85D^ΔC40B (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by rl^13R (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by spi¹ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by Su(tor)2-28-23^2-28-23 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by Su(tor)2-187-2^2-187-2 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by Su(tor)2-280-28^2-280-28 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by Su(tor)2-341-39^2-341-39 (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by tkv⁷ (Zhang et al., 1999) Src42A^Su(phl)1-1 has phenotype, non-suppressible by vn^ddd-4 (Zhang et al., 1999)
Suppressor of
Statement Reference Src42A^Su(phl)1-1 is a suppressor \| partially of ommatidium phenotype of phl¹ (Zhang et al., 1999) Src42A^Su(phl)1-1 is a suppressor \| partially of photoreceptor cell R7 phenotype of phl¹ (Zhang et al., 1999) Src42A^Su(phl)1-1 is a suppressor of eye phenotype of Dsor1^XS520 (Lu and Li, 1999) Src42A^Su(phl)1-1 is a suppressor of eye phenotype of phl¹ (Lu and Li, 1999, Lu et al., 1994) Src42A^Su(phl)1-1 is a suppressor of eye phenotype of Sos^AM14 (Lu and Li, 1999) Src42A^Su(phl)1-1 is a suppressor of eye phenotype of Sos^x122 (Lu and Li, 1999) Src42A^Su(phl)1-1 is a suppressor of ommatidium phenotype of phl¹ (Lu and Li, 1999) Src42A^Su(phl)1-1 is a suppressor of photoreceptor cell R7 phenotype of phl¹ (Lu and Li, 1999)
Additional Comments
Genetic Interactions
Statement Reference Suppresses the lethality of phl¹. Lethality at the pupal stage is seen in Src42A^Su(phl)1-1 Ras85D^V12.sev or Src42A^Su(phl)1-1 phl::tor^13D.hs.sev double heterozygotes. The rough eye phenotype of hemizygous phl¹ pharate adult males is also suppressed by Src42A^Su(phl)1-1. Dominantly suppresses the rough eye phenotype of Dsor1^XS520 and Sos^x122/Sos^AM14. (Lu and Li, 1999) Suppresses the phl¹ phenotype; phl¹/Y flies die, whereas phl¹/Y ; Src42A^Su(phl)1-1/+ flies are viable and fertile. phl¹/Y pharate adults have rough eyes and the R7 cell is missing in 88% of ommatidia. Rescued phl¹/Y ; Src42A^Su(phl)1-1/+ flies have rough eyes and the R7 cell is missing in 36% of ommatidia. The ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies is dominantly suppressed by Egfr^unspecified, Egfr^f24, rl¹⁰, Df(2R)M41A10, drk^ΔP24, Sos^x122, Sos^34Ea-6, Ras85D^e2F, Ras85D^e1B, Ras85D⁰⁵⁷⁰³, spi^SC1, Df(2L)ast2, S^IIN, rho^7M43, 14-3-3ζ⁰⁷¹⁰³, bowl⁸⁵, bowl^2-17-29-5, Su(tor)2-164-14^2-164-14, Su(tor)278-22^278-22, Su(tor)2-113-31^2-113-31, Su(tor)2-68-20^2-68-20, Su(tor)2-321¹, Su(H)⁸, Df(3R)Dl-M2, Ser^rev6-1, Egfr^40-6, Egfr^30-1, Egfr^9-2, Egfr^24-1, Egfr^26-3, Egfr⁴, Egfr⁵, Egfr⁶, Egfr⁹, Egfr¹⁵, Egfr²⁷, rl^41-1, rl^A3-2, rl^21-1, rl^Z3, rl^Z7, rl¹⁹, sag^32-3, sag^A4-2, sag^16-2, sag⁸, sag¹⁶, sag¹⁸, sag³³, sag^13L, Su(SuRaf1)IV^A7-2, Su(SuRaf1)IV⁴, Su(SuRaf1)19-2^19-2, Su(SuRaf1)A2-1^A2-1, Su(SuRaf1)1¹, Su(SuRaf1)2², Su(SuRaf1)10¹⁰, Su(SuRaf1)11¹¹ or Su(SuRaf1)12¹². The ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies is not suppressed by Ras85D^ΔC40B, spi¹, vn^ddd-4, bowl^2-60-20, Su(tor)2-187-2^2-187-2, Su(tor)2-280-28^2-280-28, Su(tor)2-341-39^2-341-39, Su(tor)2-28-23^2-28-23, bib⁷, Df(3R)Espl4, neur¹¹, mam²¹, tkv⁷, Mad¹², rl^13R or put¹³⁵. (Zhang et al., 1999) One copy is able to rescue the lethality of phl¹, phl¹² and Dsor1^LH110 homozygotes, partially rescue the eye defect of phl¹ male hemizygotes and allow phl¹ homozygous females to produce few eggs with variable phenotype, fused or normal dorsal appendages. (Lu et al., 1994)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Src42A^1.15 (Lu and Li, 1999) Src42A^7-4 (Lu and Li, 1999) Src42A^9-4 (Lu and Li, 1999) Src42A^15-1 (Lu and Li, 1999) Src42A^18-2 (Lu and Li, 1999) Src42A^k10108 (Lu and Li, 1999) Src42A^k10115 (Zhang et al., 1999, Lu and Li, 1999)
Rescued by	Src42A^Su(phl)1-1 is rescued by Src42A^Ubi-p63E.PL (Zhang et al., 1999, Lu and Li, 1999)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Src42A^Su1 (Read et al., 2004) Src42A^Su(phl)1-1 Src42A^Su(Raf)1 (Zhang and Lu, 2000, Lu and Li, 1999) Su(phl)1¹ Su(Raf)1 (Zhang et al., 1999) unnamed (Lu et al., 1994)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Read et al., 2004, Mol. Cell. Biol. 24(15): 6676--6689 Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. [FBrf0179404] Zhang and Lu, 2000, Mech. Dev. 95(1-2): 113--122 semang affects the development of a subset of cells in the Drosophila compound eye. [FBrf0130193] Lu and Li, 1999, Dev. Biol. 208(1): 233--243 Drosophila Src42A is a negative regulator of RTK signaling. [FBrf0107862] Zhang et al., 1999, Genetics 151(2): 697--711 A genetic screen for modifiers of Drosophila Src42A identifies mutations in egfr, rolled and a novel signaling gene. [FBrf0107534] Lu et al., 1994, EMBO J. 13(11): 2592--2599 Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction. [FBrf0073777]

Allele Dmel\Src42ASu(phl)1-1

Allele Dmel\Src42A^Su(phl)1-1