Allele Dmel\Ubx^MX17

General Information
Symbol	Dmel\Ubx^MX17	Species	D. melanogaster
Name		FlyBase ID	FBal0039099
Feature type	allele	Associated gene	Dmel\Ubx

Allele class	hypomorphic allele - genetic evidence
Mutagen	X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Busturia et al., 1990)
Mutagen	X ray (Busturia et al., 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Inversion of 18kb with breakpoints flanking exon mII. Right breakpoint maps to coordinate -46kb in intron 2 (coordinates of FBrf0040194). (Subramaniam et al., 1994) A fragment of about 18kb, from -64kb to -46kb (coordinates of FBrf0040194), is in reverse orientation. This alteration inverts the second microexon of the Ubx transcription unit and flanking intronic sequences, placing the coding sequences and splice site on the non-transcribed strand. Mutants will not be able to produce any transcript including microexon 2. (Busturia et al., 1990)
Cytology	Polytene chromosomes normal. (Micol and Garcia-Bellido, 1988)
Phenotypic Data
Phenotypic Class
	viable (Micol and Garcia-Bellido, 1988) visible (Busturia et al., 1990, de Navas et al., 2011)
Phenotype Manifest In
	abdominal 1 dorsal transverse muscle 1 (Reed et al., 2010) abdominal 1 lateral transverse muscle (Reed et al., 2010) abdominal 2 dorsal transverse muscle 1 (Reed et al., 2010) abdominal 2 lateral transverse muscle (Reed et al., 2010) abdominal segment 1 (Busturia et al., 1990) chordotonal organ (Subramaniam et al., 1994) chordotonal organ & axon (Subramaniam et al., 1994) haltere (Busturia et al., 1990, de Navas et al., 2011) metathoracic leg (de Navas et al., 2011) metathoracic metatarsus (de Navas et al., 2011) peripheral nervous system & parasegment 5 (Subramaniam et al., 1994) peripheral nervous system & parasegment 6 (Subramaniam et al., 1994) wing \| ectopic (de Navas et al., 2011)
Detailed Description
	Statement Reference Homozygotes show partial transformation of haltere to wing and the number of bristles in the first abdominal segment is reduced compared to wild type. 83% of mutant metathoracic legs have a small apical bristle in the anterior compartment, similar to that found in the wild-type mesothoracic leg. The number of big bristles present n the posterior compartment of the metathoracic basitarsus is reduced, indicating a partial transformation into the basitarsus of the wild-type mesothoracic leg (which has no bristles). (de Navas et al., 2011) Abdominal segments A1 and A2 show transformation towards thoracic identity in mutant embryos; the dorsal transverse 1 muscle is lost and the lateral transverse muscles have a thinner, more thoracic-like morphology than normal. The ventral acute 2 muscle is still present in the mutant A1 and A2 segments. (Reed et al., 2010) Dorsal chordotonal organs of T2 and T3 are transformed into T1-like lateral chordotonal organs whose axons project into the more posterior segment. This phenotype is not 100% penetrant. Extra monoscolopoid chordotonal organs appear in the ventral regions of T3 and A1, when all components of dorsal chordotonal organ 3 are present. Ectopic chordotonal organs are rare in other Ubx mutants. In general there is a loss of specific cells, sensory organs or entire cell clusters from PS6 without replacement by elements from PS5 or PS4. PNS elements that disappear from A1 with high frequency in Ubx^MX17 appear with low frequency in the thoracic segments of Ubx^IVa.hs, and vice versa. (Subramaniam et al., 1994) Homozygotes and Ubx^MX17/Ubx^MX19 transheterozygotes show a slight but clear transformation of haltere to wing. The transformation appears stronger in trans to Df(3R)P9. Only the distal part of the appendage is affected. There is a partial transformation of the first abdominal segment to thorax as indicated by the reduced number of bristles. There is no detectable embryonic phenotype. (Busturia et al., 1990) Weak allele. (Micol and Garcia-Bellido, 1988)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Ubx^MX17 (Reed et al., 2010, de Navas et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	de Navas et al., 2011, Development 138(1): 107--116 Integration of RNA processing and expression level control modulates the function of the Drosophila Hox gene Ultrabithorax during adult development. [FBrf0212483] Reed et al., 2010, Genetics 184(3): 745--758 Alternative splicing modulates Ubx protein function in Drosophila melanogaster. [FBrf0210406] Hatton et al., 1998, Mol. Cell 2(6): 787--796 Generation of alternative Ultrabithorax isoforms and stepwise removal of a large intron by resplicing at exon-exon junctions. [FBrf0105838] Subramaniam et al., 1994, Genetics 136(3): 979--991 Functional differences between Ultrabithorax protein isoforms in Drosophila melanogaster: evidence from elimination, substitution and ectopic expression of specific isoforms. [FBrf0074561] Busturia et al., 1990, EMBO J. 9: 3551--3555 Different forms of Ultrabithorax proteins generated by alternative splicing are functionally equivalent. [FBrf0051648] Micol and Garcia-Bellido, 1988, Proc. Natl. Acad. Sci. U.S.A. 85: 1146--1150 Genetic analysis of 'transvection' effects involving Contrabithorax mutations in Drosophila melanogaster. [FBrf0048913]
Abstract	Hatton and Lopez, 1999, A. Dros. Res. Conf. 40: 482A A role for exon coupling in Ultrabithorax splicing regulation. [FBrf0106623]

Allele Dmel\UbxMX17

Allele Dmel\Ubx^MX17