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General Information
Symbol
Dmel\exdEM5
Species
D. melanogaster
Name
FlyBase ID
FBal0039336
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T15994534A

Amino acid change:

Y258N | exd-PA; Y258N | exd-PB; Y258N | exd-PD; Y258N | exd-PE

Reported amino acid change:

Y?N

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: T978A. Amino acid replacement: Y?N. Missense mutation within the homeodomain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

If the maternal component of exd is increased occasional pharate adults are obtained that can be dissected from the pupal case. These flies lack proximal leg structures while distal structures are normal. The survival of gynandromorph mosaic individuals is 41%. Abdominal segments 1 to 5 are unaffected and clones within segment 6 often retain their appropriate identity, those that are transformed have an A5 identity. Clones within abdominal segment 7 are always transformed anteriorly toward A6, evidenced by differentiation into a tergite lacking trichomes. Clones in female genitalia also show anterior-ward transformation, clones in the male genitalia have subtle effects. Clones in the head could encompass any region. Clones in the antenna cause a size reduction and slight thickening of the arista which may indicate a partial transformation toward leg. Mitotic clones in the distal tarsal regions of the leg survive and participate in normal patterning. Clones located in the proximal regions either do not survive, grossly distort pattern and reduce leg segment size or make ectopic clusters of bristles in regions of leg usually devoid of bristles. The segment identities of mutant legs are not affected.

Weak allele. Homozygotes die as pharate adults with specific cuticular defects. exdEM5 embryos lacking maternal as well as zygotic exd function have reduced denticle bands in T3 and T2 which resemble the wild-type T1 beard. The denticles and dorsal hairs of T1 are eliminated, the only remnants of T1 being the ventral pit and Keilin's organ.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)