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General Information
Symbol
Dmel\aosW11
Species
D. melanogaster
Name
FlyBase ID
FBal0039377
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
aos-lacZ, argosw11, aos-lacZW11, W11, aosw11-lacZ, argos-lacZ
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
P{lwB} insertion 500bp downstream of the P{lArB} insertion of argosA254.
P{lwB} insertion within the 5' exon.
Insertion components
P{lwB}aosW11
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
argosΔ7/argosW11 flies have blisters in the eye. Only 5% of eggs derived from argosΔ7/argosW11 have defects in dorsal appendage morphology, which include a reduced distance between the two appendages and appendages that are shorter than normal.
Heterozygotes show a direct effect on the shape of the wing.
When homozygous mutant clones are made in the eye, although many of the mutant ommatidia have too many photoreceptors, a significant proportion have the correct number. many of these ommatidia are misrotated.
Mutant eye discs show, in addition to the extra R-cell phenotype, severe ommatidial rotation defects, though the initial 45oC rotation seen in wild-type is less affected.
argosΔ7/argosW11 hypomorphic females lay a significant proportion of eggs with fused dorsal appendages. Larvae hatch from the eggs, with dorsal-ventral pattern unperturbed.
The number of midline glia cells is increased to an average of 5.1 +/- 0.2 cells per segment in homozygous embryos.
Retinal degeneration in aging flies.
Mutant ommatidia have extra pigment cells.
Reduced viability and rough eye phenotype, including blistering in the posterior region of the eye due to a lawn of undifferentiated cells in the pupal eye. Eyes have abnormal rhabdomere morphology and extra outer photoreceptors. Optic lobes are small and disorganised. Many of the mystery cells start differentiating as neurons and never leave the developing ommatidia. Extra cone cells and an abnormally high number of primary pigment cells are found in the pupal eye. Interommatidial bristle precursors are disorganised though the total number appears to be normal.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
aos[+]/aosW11 is an enhancer of visible phenotype of Chmp1GD11219, Scer\GAL4Bx-MS1096
argos[+]/aosW11 is an enhancer of visible phenotype of Scer\GAL4en-e16E, Socs44AUAS.cRa
aosW11 is an enhancer of visible phenotype of EgfrE3/EgfrE1
NOT Enhancer of
Statement
Reference
argos[+], aosW11, N[+], N55e11 is a non-enhancer of planar polarity defective phenotype of Pcyt116919
Suppressor of
Statement
Reference
aosW11 is a suppressor of visible phenotype of EgfrE3/EgfrE1
Phenotype Manifest In
Enhancer of
Statement
Reference
argos[+]/aosW11 is an enhancer of wing vein | ectopic phenotype of Scer\GAL4en-e16E, Socs44AUAS.cRa
aosW11 is an enhancer of wing phenotype of EgfrE3/EgfrE1
aosW11 is an enhancer of wing vein | ectopic phenotype of EgfrE3/EgfrE1
NOT Enhancer of
Statement
Reference
argos[+], aosW11, N[+], N55e11 is a non-enhancer of eye photoreceptor cell phenotype of Pcyt116919
argos[+], aosW11, N[+], N55e11 is a non-enhancer of ommatidium phenotype of Pcyt116919
Suppressor of
Statement
Reference
aosW11 is a suppressor of eye phenotype of EgfrE3/EgfrE1
Additional Comments
Genetic Interactions
Statement
Reference
The ectopic wing vein phenotype caused by expression of Socs44AScer\UAS.cRa under the control of Scer\GAL4en-e16E is enhanced by argosW11/+.
argosW11 enhances the edk01102 phenotype; the number of ommatidia with multiple R8 cells is increased from 21% to 46% in the double mutant flies.
The Cct116919 defective eye phenotype is not significantly enhanced in Cct116919/+, argosW11/+, N55e11/+ triple heterozygotes.
argosW11 enhances the extra wing vein phenotype of EgfrE1/EgfrE3 transheterozygotes, but suppresses the eye phenotype.
No effect on the faf eye phenotype.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments
Excision of the P{lwB} insertion reverts the mutant phenotype to wild type.
argosW11 chromosome also carries a mutation at chp, chpW11, that causes strong rhabdomere defects. Mutation can be recombined off the chromosome.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (27)