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General Information
Symbol
Dmel\orbF303
Species
D. melanogaster
Name
FlyBase ID
FBal0039707
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T23266431A

Reported nucleotide change:

T?A

Amino acid change:

Y742N | orb-PA; Y740N | orb-PB; Y386N | orb-PC; Y740N | orb-PD; Y386N | orb-PE; Y444N | orb-PF; Y742N | orb-PG

Reported amino acid change:

Y742N

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Y742N.

Nucleotide substitution: T?A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

75% of embryos derived from heterozygous female hatch.

16 cell cysts form in mutant ovaries, but the oocyte is abnormal and is located in the centre of the cyst.

Oogenesis is arrested just after the formation of the 16-cell cyst in mutant ovaries. The presumptive oocyte remains in the centre of the cluster, rather than migrating to the posterior pole.

Ovarian development has arrested at an early stage but a few egg chambers are seen, some have aberrant morphology.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

orbF303 has female sterile | recessive phenotype, non-suppressible by ypsJM2

Phenotype Manifest In
Suppressed by
Statement
Reference

orbF303/orbmel has oocyte phenotype, suppressible | partially by ypsJM2/ypsJM2

NOT suppressed by
Statement
Reference
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

30% of embryos derived from BicC5/+ ; orbF303/+ females hatch. Of the non-hatching embryos, 62% are bicaudal and 30% have head defects.

Wild-type patterns of microtubule distribution and cytoplasmic streaming are restored in half of orbmel/orbF303 oocytes if they are also homozygous for ypsJM2.

The failure of most eggs derived from orbmel/orbF303 females to hatch is partially suppressed by ypsJM2/ypsJM2 (40% of eggs derived from the double mutant females hatch). Eggs laid by ypsJM2 orbmel/ypsJM2 orbF303 females have fused, reduced or absent dorsal appendages. 5% of ypsJM2 orbmel/ypsJM2 orbF303 egg chambers are bipolar.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

C. Nusslein-Volhard.

Comments
Comments

Class II orb allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
  • FBal0127197
References (13)