Allele Dmel\per^+t7.2

General Information
Symbol	Dmel\per^+t7.2	Species	D. melanogaster
Name		FlyBase ID	FBal0039741
Feature type	allele	Associated gene	Dmel\per

Allele class
Mutagen	in vitro construct - genomic fragment
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - genomic fragment (Hardin et al., 1990, Frisch et al., 1994, Cooper et al., 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Consists of a truncated per gene in which the promoter and a portion of the first (non-coding) exon are deleted. (Krishnan et al., 1999) Construct: 7.2kb per DNA, 5' end begins within the first intron so contains all coding regions and 3' flanking sequence. 5' end is 800bp closer to the second intron than per^+t14.6 or per^+t8.0. (Cooper et al., 1994) Promoterless 7.2kb genomic fragment of per. (Frisch et al., 1994) 7.2kb fragment that contains all the per coding DNA, but is missing much of the non-coding DNA, including exon 1. (Hardin et al., 1990)
Carried in construct	P{perC7.2} (Levine et al., 2002, Cooper et al., 1994, Frisch et al., 1994, Krishnan et al., 1999, Frisch et al., 1993, So and Rosbash, 1997, Hardin et al., 1990, Hamblen-Coyle et al., 1992, Beaver and Giebultowicz, 2004, Yu et al., 1987, Mazzoni et al., 2005, Fujii et al., 2007, Donlea et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	circadian rhythm defective (Hamblen-Coyle et al., 1992) mating rhythm defective \| male limited, with per⁰¹ (Fujii et al., 2007) wild-type (Frisch et al., 1994, Cooper et al., 1994)
Phenotype Manifest In

Detailed Description
	Statement Reference Rescue circadian behavioural rhythms of per⁰¹ flies. Exhibit free-running, temperature-compensated behavioural rhythms and can also entrain and re-entrain to LD cycles. (Frisch et al., 1994) Long cycle duration, the evening peak of activity is shifted to a later time than wild type. (Hamblen-Coyle et al., 1992) per⁰¹ flies transformed with this allele are frequently rhythmic, though circadian periods are slightly longer than the normal range. (Yu et al., 1987)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	per^+t7.2 rescues per⁰¹ (Frisch et al., 1994, Cooper et al., 1994, Mazzoni et al., 2005, Donlea et al., 2009)
Partially rescues	per^+t7.2 partially rescues per⁰¹ (Beaver and Giebultowicz, 2004)
Fails to rescue	per^+t7.2 fails to rescue per⁰¹ (Krishnan et al., 1999, Fujii et al., 2007)
Comments	per[01]; per[+t7.2] flies display normal experience-dependent increase in sleep. per[01]; per[+t7.2] flies display long-term memory and increase in sleep. (Donlea et al., 2009) The pronounced circadian rhythm of close-proximity encounters seen in wild-type male:female pairs is lost when the male is hemizygous for per[01]. This phenotype is not rescued by P{perC7.2}2. (Fujii et al., 2007) The blindness of per[01] mutants at 750 lux is rescued by the presence of per[+t7.2], whose expression is limited to the LNs. (Mazzoni et al., 2005) The extension of time spent copulating seen in per⁰¹ hemizygous males mated with wild type females is not suppressed by per^+t7.2, even though it does rescue rhythmic locomoter activity in these flies. (Beaver and Giebultowicz, 2004) Circadian rhythms in olfactory responses to ethyl acetate are abolished in per⁰¹ mutants that also have the P{perC7.2} transgene. (Krishnan et al., 1999) Rescues the arrhythmicity of per⁰¹ flies. (Cooper et al., 1994)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	per expression, with respect to behavioural circadian rhythms, is dosage compensated. (Cooper et al., 1994)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	per^+t7.2
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Donlea et al., 2009, Science 324(5923): 105--108 Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. [FBrf0207700] Mazzoni et al., 2005, Neuron 45(2): 293--300 Circadian pacemaker neurons transmit and modulate visual information to control a rapid behavioral response. [FBrf0184213] Beaver and Giebultowicz, 2004, Curr. Biol. 14(16): 1492--1497 Regulation of copulation duration by period and timeless in Drosophila melanogaster. [FBrf0180057] Levine et al., 2002, Science 298(5600): 2010--2012 Resetting the circadian clock by social experience in Drosophila melanogaster. [FBrf0155497] So and Rosbash, 1997, EMBO J. 16(23): 7146--7155 Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling. [FBrf0099738] Cooper et al., 1994, Genetics 138(3): 721--732 Dosage compensation of the period gene in Drosophila melanogaster. [FBrf0079957] Frisch et al., 1994, Neuron 12(3): 555--570 A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. [FBrf0068497] Hamblen-Coyle et al., 1992, J. Insect Behav. 5(4): 417--446 Behavior of period-altered circadian rhythm mutants of Drosophila in light:dark cycles (Diptera, Drosophilidae). [FBrf0056532] Hardin et al., 1990, Nature 343(6258): 536--540 Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. [FBrf0052650] Yu et al., 1987, Proc. Natl. Acad. Sci. U.S.A. 84: 784--788 Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster. [FBrf0047238]
Supplementary material	Fujii et al., 2007, Curr. Biol. 17(3): Nocturnal male sex drive in Drosophila. Supplementary material. [FBrf0208091]
Abstract	Frisch et al., 1993, Davis, Zipursky, 1993: 161 Cyclic expression of the period (per) gene in 5'-less transgenic flies. [FBrf0099215]
Letter	Krishnan et al., 1999, Nature 400(6742): 375--378 Circadian rhythms in olfactory responses of Drosophila melanogaster. [FBrf0110109]

Allele Dmel\per+t7.2

Allele Dmel\per^+t7.2