FB2025_01 , released February 20, 2025
Allele: Dmel\plu6
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General Information
Symbol
Dmel\plu6
Species
D. melanogaster
Name
FlyBase ID
FBal0039765
Feature type
allele
Associated gene
Dmel\plu
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Axton et al., 1994)
Progenitor genotype
plu1
(Axton et al., 1994)
Cytology
Description

An inversion or insertion.

(Axton et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos undergo extensive DNA replication without nuclear division and form a fused giant polyploid nuclei from the male and female pronuclei and from the polar body nuclei.

      (Axton et al., 1994)

      Transheterozygotes with plu2 produce a few viable adult progeny.

      (Shamanski and Orr-Weaver, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      plu6 has egg & nucleus phenotype, non-enhanceable by gnuUAS.EGFP/Scer\GAL4VP16.mat.αTub67C

      (Renault et al., 2003)
      Suppressed by
      Statement
      Reference

      plu6 has phenotype, suppressible by CycB+t10

      (Lee et al., 2001)
      NOT suppressed by
      Statement
      Reference

      plu6 has egg & nucleus phenotype, non-suppressible by gnuUAS.EGFP/Scer\GAL4VP16.mat.αTub67C

      (Renault et al., 2003)

      plu6 has polar body nucleus phenotype, non-suppressible by CycB+t10

      (Lee et al., 2001)
      Suppressor of
      Statement
      Reference

      plu6 is a suppressor of nurse cell & nucleus phenotype of Scer\GAL4VP16.mat.αTub67C, gnuUAS.EGFP

      (Renault et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      39% of embryos derived from plu6 females carrying 4 copies of CycB+t10 are multinucleated, compared to only 1.5% of those derived from plu6 single mutant females. The polar body defects are not corrected.

      (Lee et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      plu6 is rescued by plu+t3.8

      (Axton et al., 1994)

      plu6 is rescued by plu+t6.5

      (Axton et al., 1994)
      Comments

      Mutant phenotype can be rescued by plu+t6.5 and plu+t3.8 construct.

      (Axton et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      plu6
      (Tadros et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)