The complete lethality of vir2f homozygous females cannot be suppressed by combination with a single copy of nito1 or FlaccC individually but heterozygosity for both does partially restore viability of the vir2f/vir2f females.
SxlM4/+ ; vir6/vir2f animals derived from females carrying homozygous vir6 germ line clones mated to vir2f/+ males survive, but are sexually transformed. SxlM4/+ ; vir2f/vir2f animals derived from females carrying homozygous vir2f germ line clones mated to homozygous vir2f males survive, but are sexually transformed. SxlM1 cannot rescue the XX progeny of females carrying homozygous vir2f germ line clones mated to homozygous vir2f males whether it is paternally or maternally inherited.
Female lethality can be rescued by msl-1γ222, msl-2γ136 or mle9 mutations, rescued animals are transformed into pseudomales. The presence of SxlM1, SxlM4 or SxlF1.hs rescues the female lethality of vir transheterozygotes, animals are strongly macsculinised and in some cases transformed to pseudomales.