Allele Dmel\w^+mF

General Information
Symbol	Dmel\w^+mF	Species	D. melanogaster
Name		FlyBase ID	FBal0040135
Feature type	allele	Associated gene	Dmel\w

Allele class
Mutagen	in vitro construct - deletion, in vitro construct
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct (Bhadra et al., 1997) in vitro construct - deletion (Levis et al., 1985, Rabinow and Birchler, 1989, Bhadra et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	w^+t9.8 (Levis et al., 1985)
Nature of the lesion	Statement Reference Deletion of cis regulatory region 5' to ScaI site. (Bhadra et al., 1997) Construct: w promoter sequences up to 360bp drive w gene expression. (Bhadra et al., 1997) Deletion of cis-regulatory region 5' to ScaI site. (Bhadra and Birchler, 1996) Synthetic deletion of regulatory region 5' to ScaI at +4.11kb. (Rabinow and Birchler, 1989) 8.32kb fragment including 2.1kb of 3' flanking sequences, 0.42kb of 5' flanking sequences and the complete w transcription unit. (Levis et al., 1985)
Carried in construct	P{wF} (Levis et al., 1985, Rabinow and Birchler, 1989, Heuer et al., 1995, Bhadra and Birchler, 1996, Bhadra et al., 1997, Bhadra et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	Malpighian tubule (Levis et al., 1985) ocellus (Levis et al., 1985) pigment cell (Levis et al., 1985)
Detailed Description
	Statement Reference No change in wild type eye pigment in the presence of Mow^gamma. (Bhadra and Birchler, 1996) Phenotype is not affected by Doa mutations. (Rabinow and Birchler, 1989) Eye colour: varies from yellow orange with spots to red-brown, depending on site of insertion. (Levis et al., 1985)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement Reference w^+mF has phenotype, non-enhanceable by Low¹ (Bhadra et al., 1997)
Suppressed by
Statement Reference w^+mF has phenotype, suppressible by Wow^ems1 (Birchler et al., 1994) w^+mF has phenotype, suppressible by Wow^hd1 (Birchler et al., 1994) w^+mF has phenotype, suppressible by Wow^γb (Birchler et al., 1994) w^+mF has phenotype, suppressible by Wow^γe (Birchler et al., 1994)
NOT suppressed by
Statement Reference w^+mF has phenotype, non-suppressible by Low¹ (Bhadra et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference The eye colour of flies carrying w^+mF in a w¹¹¹⁸ background is unaffected by a single copy of Low¹. (Bhadra et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 3 )
Bloomington	4542 y¹ w^*; Df(2R)Chi^g230, P{wF}4-1/CyO-Df(2R)B80, y⁺ 5152 w¹¹¹⁸; P{wF}mas^P ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹
Kyoto	107790 y¹ w^*; Df(2R)Chi^g230, P{wF}4-1/CyO, Ts(Y;2Lt)B80, Kr^- y⁺
Notes on Origin
Discoverer

Comments
	Protein fails to interact with Ufo¹. (Bhadra et al., 1997) Does not interact with z¹. (Levis et al., 1985)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	w^-360 w^+mF w^F
Name Synonym
Secondary FlyBase IDs
	FBal0060841
References ( 7 )
Research paper	Bhadra et al., 1997, Genetics 146(3): 903--917 A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats. [FBrf0094158] Bhadra et al., 1997, Mol. Gen. Genet. 254(6): 621--634 A trans-acting modifier causing extensive overexpression of genes in Drosophila melanogaster. [FBrf0094159] Bhadra and Birchler, 1996, Mol. Gen. Genet. 250(5): 601--613 Characterization of a sex-influenced modifier of gene expression and suppressor of position-effect variegation in Drosophila. [FBrf0086910] Heuer et al., 1995, Development 121(11): 3861--3876 The Drosophila homeotic target gene centrosomin, cnn, encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis. [FBrf0084021] Birchler et al., 1994, Genetics 137(4): 1057--1070 Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster. [FBrf0074960] Rabinow and Birchler, 1989, EMBO J. 8: 879--889 A dosage-sensitive modifier of retrotransposon-induced alleles of the Drosophila white locus. [FBrf0049635] Levis et al., 1985, EMBO J. 4(13A): 3489--3499 Separable cis-acting control elements for expression of the white gene of Drosophila. [FBrf0042436]

Allele Dmel\w+mF

Allele Dmel\w^+mF