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General Information
Symbol
Dmel\InR31
Species
D. melanogaster
Name
FlyBase ID
FBal0042639
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G21575066A

Amino acid change:

W1587term | InR-PA; W1587term | InR-PB; W1587term | InR-PC; W1587term | InR-PD

Reported amino acid change:

W1439term

Comment:

Mutation is in the cytoplasmic region.

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation. InR[31] and InR[304] have mutations at adjacent G residues; specific changes for each not reported. The mutation was annotated at the second base of the codon.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W1439term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Selective removal of InRE19 function in eye progenitor cells generates flies with strongly reduced eye and head capsule while all other parts are wild-type. Mosaic eyes show photoreceptors that are reduced in size by more than half.

CNS defect and failure of germ band retraction, failure dorsal closure and defects in head structure.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference

InR31 is a non-enhancer of visible phenotype of upd1GMR.PB

NOT Suppressor of
Statement
Reference

InR31 is a non-suppressor of visible phenotype of upd1GMR.PB

Phenotype Manifest In
NOT Enhancer of
Statement
Reference

InR31 is a non-enhancer of eye phenotype of upd1GMR.PB

NOT Suppressor of
Statement
Reference

InR31 is a non-suppressor of eye phenotype of upd1GMR.PB

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Alleles of InR form an allelic series based on phenotypic strength: InR339 > InR31 > InR211 > InRE19 > InR353.

When in trans with Df(3R)e-D7 the lethal phenotype can be rescued by P{hs-inr}.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)