Allele Dmel\InR³²⁷

General Information
Symbol	Dmel\InR³²⁷	Species	D. melanogaster
Name		FlyBase ID	FBal0042640
Feature type	allele	Associated gene	Dmel\InR

Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Fernandez et al., 1995)
Mutagen	ethyl methanesulfonate (Fernandez et al., 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Fernandez et al., 1995) lethal \| larval stage (with InR³⁰⁴) (Oldham et al., 2002) small body \| somatic clone (Oldham et al., 2002)
Phenotype Manifest In
	commissure (Fernandez et al., 1995) embryonic/first instar larval cuticle (Fernandez et al., 1995) embryonic/larval brain \| embryonic stage (Fernandez et al., 1995) embryonic head (Fernandez et al., 1995) extended germ band embryo (Fernandez et al., 1995) fascicle (Fernandez et al., 1995) longitudinal connective (Fernandez et al., 1995)
Detailed Description
	Statement Reference Mosaic flies in which the head is composed of homozygous InR³²⁷ cells (clones generated using the "eyFLP" system) have disproportionally small heads ("pin head" phenotype). (Oldham et al., 2002) Cell size is reduced by 28% in InR³²⁷/InR³¹³ flies. (Bohni et al., 1999) CNS defect and failure of germ band retraction, failure dorsal closure and defects in head structure. (Fernandez et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference InR³²⁷/InR³⁰⁴ has lethal \| larval stage phenotype, suppressible \| partially by Pten^2L100/Pten¹¹⁷ (Oldham et al., 2002)
NOT Enhancer of
Statement Reference InR³²⁷ is a non-enhancer of visible phenotype of os^GMR.PB (Bach et al., 2003)
NOT Suppressor of
Statement Reference InR³²⁷ is a non-suppressor of visible phenotype of os^GMR.PB (Bach et al., 2003)
Other
Statement Reference InR³²⁷/InR³⁰⁴, Pten^2L100/Pten¹¹⁷ has lethal \| pupal stage phenotype (Oldham et al., 2002, Oldham et al., 2002)
Phenotype Manifest In
NOT Enhancer of
Statement Reference InR³²⁷ is a non-enhancer of eye phenotype of os^GMR.PB (Bach et al., 2003)
NOT Suppressor of
Statement Reference InR³²⁷ is a non-suppressor of eye phenotype of os^GMR.PB (Bach et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference Mosaic flies in which the head is doubly mutant for InR³²⁷ and Pten¹¹⁷ have heads which are almost the size of heads singly mutant for Pten¹¹⁷. (Oldham et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	When in trans with Df(3R)e-D7 the lethal phenotype can be rescued by P{hs-inr}. (Fernandez et al., 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	InR³²⁷
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Bach et al., 2003, Genetics 165(3): 1149--1166 A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. [FBrf0167623] Oldham et al., 2002, Development 129(17): 4103--4109 The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP₃ levels. [FBrf0151278] Bohni et al., 1999, Cell 97(7): 865--875 Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. [FBrf0108621] Fernandez et al., 1995, EMBO J. 14(14): 3373--3384 The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential. [FBrf0081989]

Allele Dmel\InR327

Allele Dmel\InR³²⁷