Allele Rnor\MAP2^Scer\UAS.cAa

General Information
Symbol	Rnor\MAP2^Scer\UAS.cAa	Species	R. norvegicus
Name	Saccharomyces cerevisiae UAS construct a of Adam	FlyBase ID	FBal0042665
Feature type	allele	Associated gene	Rnor\MAP2

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Adam, 1996.1.17)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: UAS sequences direct the expression of Rnor\MAP2 c-transcript coding region. (Adam, 1996.1.17)
Carried in construct	P{UAS-MAP2.A} (Warrick et al., 1999, Hummel et al., 2000, Adam, 1996.1.17)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^unspecified (Warrick et al., 1999)
Phenotype Manifest In
	eye, with Scer\GAL4^unspecified (Warrick et al., 1999)
Detailed Description
	Statement Reference Expression of Rnor\MAP2^Scer\UAS.cAa under the control of Scer\GAL4^unspecified produces a disrupted eye phenotype. (Warrick et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement Reference Rnor\MAP2^Scer\UAS.cAa, Scer\GAL4^unspecified has visible phenotype, non-suppressible by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^unspecified (Warrick et al., 1999)
Phenotype Manifest In
Enhanced by
Statement Reference Rnor\MAP2^Scer\UAS.cAa, Scer\GAL4⁴⁴ has axon phenotype, enhanceable by futsch^EP1419, Scer\GAL4⁴⁴ (Hummel et al., 2000)
NOT suppressed by
Statement Reference Rnor\MAP2^Scer\UAS.cAa, Scer\GAL4^unspecified has eye phenotype, non-suppressible by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^unspecified (Warrick et al., 1999)
Enhancer of
Statement Reference Rnor\MAP2^Scer\UAS.cAa, Scer\GAL4⁴⁴ is an enhancer of axon phenotype of Scer\GAL4⁴⁴, futsch^EP1419 (Hummel et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Expression of futsch^EP1419 and Rnor\MAP2^Scer\UAS.cAa driven by Scer\GAL4⁴⁴ results in frequent axonal swellings and misprojection phenotypes. In 1/5 of neuromeres sensory neurons project their axons in on one of the two commissures across the central nervous system (CNS) midline and fasciculate with their contralateral counterparts, which they never do in wild-type. (Hummel et al., 2000) The disrupted eye phenotype produced by expression of Rnor\MAP2^Scer\UAS.cAa under the control of Scer\GAL4^unspecified is not modified by coexpression of Hsap\HSPA1L^Scer\UAS.cWa. (Warrick et al., 1999)
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	128 y¹ w¹¹¹⁸; P{UAS-MAP2.A}48C
Kyoto	105749 y¹ w¹¹¹⁸; P{UAS-MAP2.A}48C
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	MAP2^UAS.cAa Rnor\MAP2^Scer\UAS.cAa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Adam (Adam, 1996.1.17)
Secondary FlyBase IDs

References ( 3 )
Research paper	Hummel et al., 2000, Neuron 26(2): 357--370 Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development. [FBrf0128497] Warrick et al., 1999, Nat. Genet. 23(4): 425--428 Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. [FBrf0123236]
Personal communication to FlyBase	Adam, 1996.1.17, UAS-M2C48C and UAS-TAU59A. UAS-M2C48C and UAS-TAU59A. [FBrf0084567]

Allele Rnor\MAP2Scer\UAS.cAa

Allele Rnor\MAP2^Scer\UAS.cAa