Mmus\Pkacahs.PJ increases the survival rate of flies that express Hsap\HDQ48.ex1p.Scer\UAS in the nervous system at 18[o]C and 22[o]C (under the regulation of Scer\GAL4elav-C155). The increase in survival rate with Mmus\Pkacahs.PJ is larger at 22[o]C than at 18[o]C (~10% at 22[o]C and ~5% at 18[o]C).
Mmus\Pkacahs.PJ completely rescues the learning defect of Nf1P1 when the flies are raised at room temperature. Mmus\Pkacahs.PJ partially rescues the learning defect of Nf1P2 when the flies are raised at room temperature, and completely rescues Nf1P2 when it is expressed using heat shock (37oC, 30 minutes). Nf1P1 and Nf1P2 flies show a short-term memory defect (3 and 8 hour retention) which is completely rescued by heat shock induced expression of Mmus\Pkacahs.PJ.