FlyBase Allele Report: Dmel\aop[A141]

General Information

Symbol

Dmel\aop^A141

Species

D. melanogaster

Name

FlyBase ID

FBal0042848

Feature type

allele

Associated gene

Dmel\aop

Associated Insertion(s)

P{lwB}aop^A141

Carried in Construct

Also Known As

yan^P

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Baril and Therrien, 2006)

Mutagen

P-element activity

(Lai and Rubin, 1992)

Progenitor genotype

Associated Insertion(s)

P{lwB}aop^A141

Cytology

Description

P-element insertion within an intron.

(Lai and Rubin, 1992)

Allele components

Component

Use(s)

Inserted element

P{lwB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity (with aop^yan-1)

(Weber et al., 2008)

partially lethal

(Lai and Rubin, 1992)

semi-sterile | recessive

(Lai and Rubin, 1992)

viable

(Baril and Therrien, 2006)

visible

(Lai et al., 1997, Lai et al., 1996, Rogge et al., 1995)

visible | recessive

(Lai and Rubin, 1992)

Phenotype Manifest In

eye

(Lai et al., 1996, Lai and Rubin, 1992)

eye photoreceptor cell

(Lai and Rubin, 1992)

ommatidium

(Rohrbaugh et al., 2002, Lai et al., 1996, Rogge et al., 1995, Lai and Rubin, 1992)

ommatidium (with aop^yan-1)

(Weber et al., 2008)

photoreceptor cell R7

(Lai et al., 1997, Lai et al., 1996)

photoreceptor cell R7 | increased number

(Baril and Therrien, 2006)

Detailed Description

Statement

Reference

aop^yan-1/aop^A141 eye discs show chirality defects in 9.4% of ommatidial clusters.

(Weber et al., 2008)

aop^A141 mutants exhibit on average 37% extra R7 cells.

(Baril and Therrien, 2006)

Homozygotes exhibit 20% mutant ommatidia.

(Rohrbaugh et al., 2002)

Eyes are mildly rough, only 20% ommatidia contain extra R7 cells.

(Lai et al., 1997)

Rough eye phenotype due to supernumerary R7 cells.

(Lai et al., 1996)

Almost wild type external appearance of the eye.

(Rogge et al., 1995)

Homozygotes have reduced viability and fertility. Weak rough eye phenotype, 20% of ommatidia contain at least one extra photoreceptor.

(Lai and Rubin, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

aop^A141 has visible phenotype, enhanceable by ttk^55.3

(Lai et al., 1997)

aop^A141 has visible phenotype, enhanceable by Dp(1;2)51b

(Rogge et al., 1995)

Suppressed by

Statement

Reference

aop^A141 has visible phenotype, suppressible by N^55e11

(Rogge et al., 1995)

Phenotype Manifest In

Enhanced by

Statement

Reference

aop^A141 has photoreceptor cell R7 | increased number phenotype, enhanceable by pp2c99B[+]/alph^S-331

(Baril and Therrien, 2006)

aop^A141 has photoreceptor cell R7 | increased number phenotype, enhanceable by alph^S-331

(Baril and Therrien, 2006)

aop^A141 has ommatidium phenotype, enhanceable by Su(H)^del47

(Rohrbaugh et al., 2002)

aop^A141 has photoreceptor cell R7 phenotype, enhanceable by ttk^55.3

(Lai et al., 1997)

aop^A141 has phenotype, enhanceable by ttk[+]/ttk⁰⁰²¹⁹

(Lai et al., 1996)

aop^A141 has phenotype, enhanceable by ttk[+]/ttk^rM730

(Lai et al., 1996)

aop^A141 has phenotype, enhanceable by Df(3R)ttk-Δ4/+

(Lai et al., 1996)

aop^A141 has ommatidium phenotype, enhanceable by Dp(1;2)51b

(Rogge et al., 1995)

aop^A141 has eye phenotype, enhanceable by RasGAP1^rI533

(Lai and Rubin, 1992)

aop^A141 has ommatidium phenotype, enhanceable by RasGAP1^rI533

(Lai and Rubin, 1992)

aop^A141 has eye photoreceptor cell phenotype, enhanceable by RasGAP1^rI533

(Lai and Rubin, 1992)

Suppressed by

Statement

Reference

aop^A141 has ommatidium phenotype, suppressible by pnt^07825Δ78

(Rohrbaugh et al., 2002)

aop^A141 has ommatidium phenotype, suppressible by N^55e11

(Rogge et al., 1995)

Enhancer of

Statement

Reference

aop^A141 is an enhancer of phenotype of svp^2.sev

(Begemann et al., 1995)

aop^A141 is an enhancer of phenotype of svp^1.sev

(Begemann et al., 1995)

aop^A141 is an enhancer of eye phenotype of rho^hs.sev

(Freeman, 1994)

Suppressor of

Statement

Reference

aop^A141 is a suppressor of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶

(Rogge et al., 1995)

Other

Statement

Reference

alph^c04528, aop^A141 has photoreceptor cell R7 | increased number phenotype

(Baril and Therrien, 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygous aop^A141 mutants, with one copy of alph^S-331 exhibit an increase from 37% to 86% in the number of extra R7 cells. Double homozygotes exhibit extra R7 cells in all ommatidia, with an average of almost three R7 cells per ommatidium, which visibly increases eye roughness.

Double homozygotes of alph^c04528 and aop^A141 exhibit extra R7 cells in all ommatidia, with an average of almost three R7 cells per ommatidium, which visibly increases eye roughness.

(Baril and Therrien, 2006)

The addition of Su(H)^del47 to aop^A141 homozygotes leads to 44% of ommatidia being mutant. The addition of Su(H)^del47 to pnt^07825Δ78 homozygotes leads to 1.3% of ommatidia being mutant.

(Rohrbaugh et al., 2002)

Loss of wild type ttk enhances the phenotype so up to 75% ommatidia contain extra R7 cells.

(Lai et al., 1997)

Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

sev⁶/sev⁺; Sos^JC2/aop^A141 mutants exhibit an increase in the number of R7 cells compared to sev⁶/Sos^JC2 mutants with two functional aop copies. Transheterozygotes with Dp(1;2)51b exhibit enhancement of the rough eye phenotype and transheterozygotes with N^55e11 exhibit suppression of the mutant eye phenotype.

(Rogge et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutant phenotype of aop^A141 can be reverted by excision of the P-element.

(Lai and Rubin, 1992)

Weak aop mutation.

(Rogge et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

aop^A141

yan^P

(Weber et al., 2008, Baril and Therrien, 2006, Rohrbaugh et al., 2002, Staehling-Hampton et al., 1999, Lai et al., 1997, Lai et al., 1996, Begemann et al., 1995, Rogge et al., 1995, Freeman, 1994, Lai and Rubin, 1992)

yanP

(Lai et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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