Embryos expressing aopACT.UAS under the double control of Scer\GAL4tin.cBa and Scer\GAL4tin.CΔ4 leads to a severe decrease in the overall number of cardioblasts (both generic and ostial cardioblasts), as compared to controls.
The expression of aopACT.UAS under the control of Scer\GAL4NP1624 leads to testes showing increased numbers of cyst stem cells (Zfh-1-positive cells), accompanied by structures that resemble stem cell, GB and spermatogonial tumors.
Expression of aopACT.Scer\UAS under the control of Scer\GAL4btl.PS inhibits specification of tracheal fusion cells and terminal cells at every branch tip.
Overexpression of aopACT.Scer\UAS in outer border cells, driven by Scer\GAL4slbo.2.6, results in a strong delay in border cell migration; 60% migrate less than 25%, 26% migrate 25-50%, 12% migrate 50-75% and 2% complete their migration.
Migration of many of the ganglionic tracheal branches is stalled or misrouted in aopACT.Scer\UAS; Scer\GAL4bs-23.26 embryos, but branches do not cross the ventral midline.
When expression is driven by Scer\GAL4He.PZ, hemocyte proliferation is increased, lamellocyte numbers are increased and crystal cells numbers are increased. Melanotic masses form.
Embryos expressing aopACT.Scer\UAS under the control of Scer\GAL4how-24B show loss of lateral adult muscle precursors and a dramatic reduction in precursors of the segmental border muscle. Embryos expressing aopACT.Scer\UAS under the control of Scer\GAL4how-24B show marked loss of cardiac cells in some segments.
Expression of aopACT.Scer\UAS in embryonic glia, under the control of Scer\GAL4repo, causes PNS patterning defects in embryonic hemisegments. In hemisegments that are moderately affected, sensory axons can be misdirected and nerves in the CNS-PNS transition zone show incorrect fasciculation-bundling. In severely-affected hemisegments, there is a loss of sensory neurons and those remaining have misplaced cell bodies and misdirected sensory axons. Additionally, motor neuron patterning is disrupted.
Expression of aopACT.Scer\UAS driven by Scer\GAL4dpp.blk1 leads to abnormal wing discs with a central cleft. In the few adult escapers that survive, a loss of macrochaetae on the scutellum is seen, and wings are small and sometimes bifurcated.
When expression is driven by Scer\GAL4hs.PB, extra cell death is induced.
Scer\GAL469B-mediated expression during embryogenesis prevents dorsal closure and results in dead embryos with a strong dorsal open phenotype.
Scer\GAL4sim.PS-mediated expression leads to fused commissures and to disruption in the longitudinal axons. Scer\GAL4sim.PS-mediated expression leads to moderate fusion of the segmental commissures.
Embryos fail to complete germ band retraction.