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General Information
Symbol
Dmel\aopACT.sev
Species
D. melanogaster
Name
activated
FlyBase ID
FBal0042853
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sev-yanACT
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Construct: Phosphoacceptor residues at the eight consensus sites within the coding region are replaced with a nonphosphorylatable amino acid, alanine. Expression is driven by an sev promoter.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

aopACT.sev mutants exhibit a rough eye phenotype.

Flies carrying aopACT.sev have a rough eye phenotype.

Mutants show reduced number of R7 photoreceptors.

Flies have rough eyes characterized by the loss of the R3, R4 and R7 photoreceptor neurons and the nonneuronal cone cells.

Eyes are slightly smaller than wild type with a rough appearance, photoreceptors R3, R4 and R7 fail to develop. Also an increase in cell death in eye tissue.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

aopACT.sev has visible phenotype, enhanceable by edl[+]/edlk06602

aopACT.sev has visible phenotype, enhanceable by edlunspecified

Enhancer of
Statement
Reference

aopACT.sev is an enhancer of visible phenotype of lzts1

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

aopACT.sev has eye phenotype, enhanceable by edl[+]/edlk06602

aopACT.sev has eye phenotype, enhanceable by edlunspecified

aopACT.sev has eye phenotype, enhanceable by EY2-5AH425

aopACT.sev has eye phenotype, enhanceable by EY2-6AC403

aopACT.sev has eye phenotype, enhanceable by EY2-6AQR618

aopACT.sev has eye phenotype, enhanceable by EY3-4x1S805

aopACT.sev has eye phenotype, enhanceable by EY3-4xII790

aopACT.sev has eye phenotype, enhanceable by EY3-5xKR845

aopACT.sev has eye phenotype, enhanceable by EY3-5xZB970

aopACT.sev has eye phenotype, enhanceable by SBA651

aopACT.sev has eye phenotype, enhanceable by SU132

aopACT.sev has eye phenotype, enhanceable by SosD120

aopACT.sev has eye phenotype, enhanceable by SosxB10

aopACT.sev has eye phenotype, enhanceable by eyaA188

aopACT.sev has eye phenotype, enhanceable by eyaG130

aopACT.sev has eye phenotype, enhanceable by retnB142

aopACT.sev has eye phenotype, enhanceable by retnx1N793

aopACT.sev has eye phenotype, enhanceable by pntAF397

aopACT.sev has eye phenotype, enhanceable by pntAP553

aopACT.sev has eye phenotype, enhanceable by rlA0648

aopACT.sev has eye phenotype, enhanceable by spenAH393

aopACT.sev has eye phenotype, enhanceable by spenBU720

aopACT.sev has phenotype, enhanceable by SosEY2-3

NOT Enhanced by
Statement
Reference

aopACT.sev has phenotype, non-enhanceable by lilliXS407/lilliXS407

aopACT.sev has phenotype, non-enhanceable by lilliXS575

aopACT.sev has phenotype, non-enhanceable by lillis35

aopACT.sev has phenotype, non-enhanceable by EY2-5DW1080

aopACT.sev has phenotype, non-enhanceable by Scer\GAL4[-]/EY2-8EP1160

aopACT.sev has phenotype, non-enhanceable by EY2-8xCB204

aopACT.sev has phenotype, non-enhanceable by EY3-2xAZ145

aopACT.sev has phenotype, non-enhanceable by EY3-2xCF301

aopACT.sev has phenotype, non-enhanceable by EY3-2xDF411

aopACT.sev has phenotype, non-enhanceable by EY3-3xBE183

aopACT.sev has phenotype, non-enhanceable by EY3-3xF6

aopACT.sev has phenotype, non-enhanceable by Su(Tpl)DI998

aopACT.sev has phenotype, non-enhanceable by Su(Tpl)EZ1217

aopACT.sev has phenotype, non-enhanceable by lilliDE884

aopACT.sev has phenotype, non-enhanceable by lilliDR999

aopACT.sev has phenotype, non-enhanceable by Sin3ACY886

aopACT.sev has phenotype, non-enhanceable by Sin3ADW1046

aopACT.sev has phenotype, non-enhanceable by glDZ1053

aopACT.sev has phenotype, non-enhanceable by glER1085

Suppressed by
Statement
Reference

aopACT.sev has eye phenotype, suppressible by aopACT.sev

aopACT.sev has ommatidium phenotype, suppressible by edslH8/ed1X5

aopACT.sev has eye phenotype, suppressible by Taf4AG456

aopACT.sev has eye phenotype, suppressible by Taf4I53

aopACT.sev has eye phenotype, suppressible by stgD115

aopACT.sev has eye phenotype, suppressible by stgDD937

NOT suppressed by
Statement
Reference

aopACT.sev has phenotype, non-suppressible by lilliXS407/lilliXS407

aopACT.sev has phenotype, non-suppressible by lilliXS575

aopACT.sev has phenotype, non-suppressible by lillis35

aopACT.sev has phenotype, non-suppressible by EY3-2xDF411

aopACT.sev has phenotype, non-suppressible by EY3-3xBE183

aopACT.sev has phenotype, non-suppressible by EY3-3xF6

aopACT.sev has phenotype, non-suppressible by Su(Tpl)DI998

aopACT.sev has phenotype, non-suppressible by Su(Tpl)EZ1217

aopACT.sev has phenotype, non-suppressible by lilliDE884

aopACT.sev has phenotype, non-suppressible by lilliDR999

aopACT.sev has phenotype, non-suppressible by Sin3ACY886

aopACT.sev has phenotype, non-suppressible by Sin3ADW1046

aopACT.sev has phenotype, non-suppressible by glDZ1053

aopACT.sev has phenotype, non-suppressible by glER1085

aopACT.sev has phenotype, non-suppressible by EY2-5DW1080

aopACT.sev has phenotype, non-suppressible by Scer\GAL4[-]/EY2-8EP1160

aopACT.sev has phenotype, non-suppressible by EY2-8xCB204

aopACT.sev has phenotype, non-suppressible by EY3-2xAZ145

aopACT.sev has phenotype, non-suppressible by EY3-2xCF301

Enhancer of
Statement
Reference

aopACT.sev is an enhancer of eye phenotype of lzts1

Suppressor of
Statement
Reference

aopACT.sev is a suppressor of eye phenotype of aopACT.sev

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

A CblK26 heterozygous background rescues the rough eye phenotype found in aopACT.sev mutants.

The rough eye phenotype caused by aopACT.sev is enhanced if the flies also carry edlk06602/+. The rough eye phenotype caused by aopACT.sev is enhanced by expression of edlScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.2sev.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Dominant activated form of aop.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Sev-YanACT
aopACT.sev
Name Synonyms
Secondary FlyBase IDs
    References (14)