Open Close
General Information
Symbol
Dmel\barrk14014
Species
D. melanogaster
Name
FlyBase ID
FBal0042875
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)k14014
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a P{lacW} element.

Insertion components
P{lacW}barrk14014
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Average Citrate Synthase activity is increased by 9% in heterozygous males

Malpighian tubules are not fully elongated in mutant embryos. Proventriculus morphogenesis and invagination of the pharynx are incomplete. Midgut constrictions do not form. Head involution is incomplete, tracheae are abnormal and there are holes in the epidermis.

Homozygous embryos exhibit severe loss of PNS neurons and a significant increase in size of remaining neurons. Embryos arrest in cycle 16.

Homozygous embryos exhibit pathfinding and organisation defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

I. Kiss.

Comments
Comments

Precise excision of the P{lacW} element reverts the lethal phenotype.

Complements: neb03552. Complements: neb05217. Complements: l(2)k10239k10239. Complements: l(2)k11537k11537. Complements: nebs4158.

P{lacW} insertion can be excised and the revert the lethal phenotype to wild type. barrk14014 and barrk14028 insertions may be members of the same cluster and not genuine alleles. Phenotypic analysis provides an allelic series: nebk00802 < barrk14014 < barrk14028 < barrk00310 < barrk13903 < barrk04805 < barrk04912.

P{lacW} insertion is revertible.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (9)