Allele Dmel\eya^unspecified

General Information
Symbol	Dmel\eya^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0042909
Feature type	allele	Associated gene	Dmel\eya
Also Known As	unspecified

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Tearle and Nusslein-Volhard, 1987) visible \| somatic clone (Bessa et al., 2002)
Phenotype Manifest In
	embryonic head (Tearle and Nusslein-Volhard, 1987) eye \| somatic clone (Bessa et al., 2002) head capsule \| somatic clone (Bessa et al., 2002) lamina \| precursor (Selleck and Steller, 1991) lateral longitudinal muscle 1 (Boyle et al., 1997) photoreceptor cell (Selleck and Steller, 1991) polar follicle cell \| ectopic \| somatic clone (Medioni and Noselli, 2005)
Detailed Description
	Statement Reference When eya^unspecified mutant clones are generated in the anterior follicle cells, ectopic polar cells form and are capped with basement membrane components. Ectopic polar cells made in the posterior region do not show an apical cap. (Medioni and Noselli, 2005) Flies containing homozygous clones show loss of eye and a corresponding increase in head capsule. (Bessa et al., 2002) The initial behaviour of germ cells is normal in mutant embryos; they contact the mesoderm and gather into bilateral groups as in wild-type embryos. However, defects in germ cell migration are seen in early germ band retraction, and germ cells are scattered throughout the posterior regions of late embryos. The final muscle pattern of the embryo is disorganised in the lateral regions, with the normal cluster of 4 lateral longitudinal muscles being absent or reduced. Dorsal and ventral oblique muscle fibres are normal. (Boyle et al., 1997) Eye discs lack photoreceptor cells. Mitotically active lamina precursor cells are absent in third instar larvae. (Selleck and Steller, 1991) Embryos show defects in head involution, and do not show segmental movements. Abdominal transformations are seen in double mutant combinations with Pc like mutants. (Tearle and Nusslein-Volhard, 1987)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Other
Statement Reference Scer\GAL4^Act5C.PP, ci^{Zn:C.Scer\UAS}, eya^unspecified has glial cell & eye phenotype (Rangarajan et al., 2001, Rangarajan et al., 2001) Scer\GAL4^bi-omb-Gal4, eya^unspecified, stg^Scer\UAS.cNa has larval optic stalk sheath cell & glial cell phenotype (Rangarajan et al., 2001, Rangarajan et al., 2001)
Additional Comments
Genetic Interactions
Statement Reference When clones of ci^{Zn:C.Scer\UAS} are made in the developing eye in a eya^unspecified background, glial cells never enter the eye disc. When stg^Scer\UAS.cNa is driven by Scer\GAL4^bi-omb-Gal4, in a eya^unspecified background, glial cells in the optic stalk undergo excessive proliferation. However these glial cells never enter the eye disc. (Rangarajan et al., 2001)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	eya^54C2 (Bai and Montell, 2002)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	cli^unspecified eya (Kim et al., 2008) eya^unspecified unspecified (Boyle et al., 1997, Jarman et al., 1995)
Name Synonym
Secondary FlyBase IDs

References ( 15 )
Research paper	Kim et al., 2008, Insect Mol. Biol. 17(5): 537--543 Characterization of the Drosophila melanogaster retinin gene encoding a cornea-specific protein. [FBrf0206102] Medioni and Noselli, 2005, Development 132(13): 3069--3077 Dynamics of the basement membrane in invasive epithelial clusters in Drosophila. [FBrf0187473] Sarfare et al., 2005, J. Biol. Chem. 280(12): 11895--11901 The Drosophila ninaG Oxidoreductase Acts in Visual Pigment Chromophore Production. [FBrf0184043] Yang et al., 2005, Nucleic Acids Res. 33(17): e148 Isolation of mRNA from specific tissues of Drosophila by mRNA tagging. [FBrf0191351] Bai and Montell, 2002, Development 129(23): 5377--5388 Eyes Absent, a key repressor of polar cell fate during Drosophila oogenesis. [FBrf0151937] Bessa et al., 2002, Genes Dev. 16(18): 2415--2427 Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt. [FBrf0152003] Lin et al., 2002, Nature 420(6917): 816--820 A role for casein kinase 2alpha in the Drosophila circadian clock. [FBrf0155498] Zheng et al., 2002, J. Biol. Chem. 277(3): 2000--2005 Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye. [FBrf0144934] Rangarajan et al., 2001, Mech. Dev. 108(1-2): 93--103 Dpp and Hedgehog mediate neuron-glia interactions in Drosophila eye development by promoting the proliferation and motility of subretinal glia. [FBrf0139746] Schulz et al., 1999, J. Biol. Chem. 274(53): 37605--37610 A novel G isolated from Drosophila constitutes a visual G protein subunit of the fly compound Eye. [FBrf0123192] Tomioka et al., 1998, J. Insect Physiol. 44(7-8): 587--596 Light and temperature cooperate to regulate the circadian locomotor rhythm of wild type and period mutants of Drosophila melanogaster. [FBrf0103487] Boyle et al., 1997, Development 124(5): 971--982 Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm. [FBrf0092473] Jarman et al., 1995, Development 121(7): 2019--2030 Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. [FBrf0080128] Selleck and Steller, 1991, Neuron 6(1): 83--99 The influence of retinal innervation on neurogenesis in the first optic ganglion of Drosophila. [FBrf0054817]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\eyaunspecified

Allele Dmel\eya^unspecified