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General Information
Symbol
Dmel\drkΔP24
Species
D. melanogaster
Name
FlyBase ID
FBal0042991
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Deletion of drk.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
     

    drkΔP24 mosaic clones are made in the antenna and the eye by using the eyFLP system.

    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Adults bearing whole-eye/antenna drkΔP24 clones have severely reduced climbing activity, suggesting defects in gravity sensing. These individuals exhibit disorganized scolopidia (as revealed by phalloidin staining, which labels cap rods, scolopale rods, and the actin bundles within the cilia of the mechanosensory neurons) and significantly smaller antennal mechanosensory motor center, indicating loss of sensory nerve terminals in the brain.

    Olfactory association learning is lower in drkΔP24 heterozygotes compared to controls. There is a 20% decrease in learning after training with 6 or less pairings.

    Histological and immunohistochemical examination of drke0A heterozygous heads with multiple antigenic markers does not reveal and gross structural anomalies in the brain. Avoidance of odors used as CS and electroshock (US) are no different from that of controls. Heterozygous mutants exhibit normal odor avoidance after pre-exposure to electric shock.

    drkΔP24 homozygous clones in the dorsal air sac primordium are found at the tip of the primordium at a significantly lower frequency than wild-type clones.

    The initiation of mesoderm spreading is unaffected in embryos derived from homozygous female germline clones.

    Mutants exhibit no defects in hemocyte migration.

    When mutant somatic clones are made in the border cells no effect is seen.

    Embryos derived from dosP115 drkΔP24 or ShcBG drkΔP24 double mutant female germline clones have a stronger phenotype than embryos derived from either single mutant female germline clone.

    Null embryos from homozygous female germlines differentiate a significant amount of cuticle. In embryos from homozygous germlines that receive a paternal wild type drk, defects in the posterior spiracles and A8, which are common in Sos mutant embryos, are rarely observed.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressor of
    Statement
    Reference

    drk[+]/drkΔP24 is a suppressor of phenotype of Src42ASu(Raf)1-1

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Expression of Ras85DV12.S35.Scer\UAS alone, or combined with the Scer\GAL4c747 driver but kept silent by Scer\GAL80ts.αTub84B does not suppress the learning deficit of drkΔP24/+ animals. In contrast, expression of Ras85DV12.S35.Scer\UAS by inactivation of the Scer\GAL80ts.αTub84B suppressor restores normal learning to drkΔP24 heterozygotes, while it does not appear to affect learning in control animals.

    Expression of phlScer\UAS.F179 alone, or combined with the Scer\GAL4c747 driver but kept silent by Scer\GAL80ts.αTub84B does not suppress the learning deficit of drkΔP24/+ animals. Conditional expression of phlScer\UAS.F179 in adult mushroom bodies reverse the learning deficit of drkΔP24 heterozygotes.

    Expression of phlScer\UAS.F179 under the control of Scer\GAL4c747 does not rescue 90 minute memory in drkΔP24/+ animals.

    Dominantly suppresses the ability of Src42ASu(phl)1-1 to suppress the lethality of phl1/Y flies.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Fails to complement
    Rescued by
    Partially rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer

    T. Raabe and E. Hafen.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (5)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
    • FBal0127235
    References (11)