Allele Dmel\drk^ΔP24

General Information
Symbol	Dmel\drk^ΔP24	Species	D. melanogaster
Name		FlyBase ID	FBal0042991
Feature type	allele	Associated gene	Dmel\drk

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Deletion of drk. (Hou et al., 1995)
Cytology
Phenotypic Data
Phenotypic Class
	learning defective (Moressis et al., 2009) memory defective (Moressis et al., 2009)
Phenotype Manifest In
	dorsal air sac primordium \| somatic clone (Cabernard and Affolter, 2005)
Detailed Description
	Statement Reference Olfactory association learning is lower in drk[ΔP24] heterozygotes compared to controls. There is a 20% decrease in learning after training with 6 or less pairings. Histological and immunohistochemical examination of drk[e0A] heterozygous heads with multiple antigenic markers does not reveal and gross structural anomalies in the brain. Avoidance of odors used as CS and electroshock (US) are no different from that of controls. Heterozygous mutants exhibit normal odor avoidance after pre-exposure to electric shock. (Moressis et al., 2009) drk[ΔP24] homozygous clones in the dorsal air sac primordium are found at the tip of the primordium at a significantly lower frequency than wild-type clones. (Cabernard and Affolter, 2005) The initiation of mesoderm spreading is unaffected in embryos derived from homozygous female germline clones. (Wilson et al., 2005) Mutants exhibit no defects in hemocyte migration. (Cho et al., 2002) When mutant somatic clones are made in the border cells no effect is seen. (Duchek et al., 2001) Embryos derived from dos^P115 drk^ΔP24 or Shc^BG drk^ΔP24 double mutant female germline clones have a stronger phenotype than embryos derived from either single mutant female germline clone. (Luschnig et al., 2000) Null embryos from homozygous female germlines differentiate a significant amount of cuticle. In embryos from homozygous germlines that receive a paternal wild type drk, defects in the posterior spiracles and A8, which are common in Sos mutant embryos, are rarely observed. (Hou et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference drk^ΔP24 has learning defective phenotype, suppressible by Scer\GAL4^c747/phl^{Scer\UAS.F179} (Moressis et al., 2009) drk^ΔP24 has learning defective phenotype, suppressible by Scer\GAL4^c747/Ras85D^{V12.S35.Scer\UAS} (Moressis et al., 2009)
NOT suppressed by
Statement Reference drk^ΔP24 has learning defective phenotype, non-suppressible by Scer\GAL4^c747/phl^{Scer\UAS.F179}/Scer\GAL80^ts.αTub84B (Moressis et al., 2009) drk^ΔP24 has learning defective phenotype, non-suppressible by Scer\GAL4^c747/Scer\GAL80^ts.αTub84B/Ras85D^{V12.S35.Scer\UAS} (Moressis et al., 2009) drk^ΔP24 has memory defective phenotype, non-suppressible by Scer\GAL4^c747/phl^fl.Scer\UAS (Moressis et al., 2009) drk^ΔP24 has memory defective phenotype, non-suppressible by Scer\GAL4^c747/phl^{Scer\UAS.F179} (Moressis et al., 2009)
Phenotype Manifest In
Suppressor of
Statement Reference drk[+]/drk^ΔP24 is a suppressor of phenotype of Src42A^Su(phl)1-1 (Zhang et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference Expression of Ras85D[V12.S35.Scer\UAS] alone, or combined with the Scer\GAL4[c747] driver but kept silent by Scer\GAL80[ts.αTub84B] does not suppress the learning deficit of drk[ΔP24]/+ animals. In contrast, expression of Ras85D[V12.S35.Scer\UAS] by inactivation of the Scer\GAL80[ts.αTub84B] suppressor restores normal learning to drk[ΔP24] heterozygotes, while it does not appear to affect learning in control animals. Expression of phl[Scer\UAS.F179] alone, or combined with the Scer\GAL4[c747] driver but kept silent by Scer\GAL80[ts.αTub84B] does not suppress the learning deficit of drk[ΔP24]/+ animals. Conditional expression of phl[Scer\UAS.F179] in adult mushroom bodies reverse the learning deficit of drk[ΔP24] heterozygotes. Expression of phl[Scer\UAS.F179] under the control of Scer\GAL4[c747] does not rescue 90 minute memory in drk[ΔP24]/+ animals. (Moressis et al., 2009) Dominantly suppresses the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies. (Zhang et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	drk^ΔP24 is rescued by drk^hs.PM (Moressis et al., 2009)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	T. Raabe and E. Hafen.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Drk^J03 (Duchek et al., 2001) drk^ΔP2 (Cho et al., 2002) drk^Δp24 (Zhang et al., 1999) drk^ΔP24 (Cabernard and Affolter, 2005, Moressis et al., 2009)
Name Synonym
Secondary FlyBase IDs
	FBal0127235
References ( 9 )
Research paper	Moressis et al., 2009, J. Neurosci. 29(8): 2611--2625 A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory. [FBrf0207513] Cabernard and Affolter, 2005, Dev. Cell 9(6): 831--842 Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. [FBrf0190195] Wilson et al., 2005, Development 132(3): 491--501 FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos. [FBrf0183935] Cho et al., 2002, Cell 108(6): 865--876 Developmental control of blood cell migration by the Drosophila VEGF pathway. [FBrf0146914] Duchek et al., 2001, Cell 107(1): 17--26 Guidance of cell migration by the Drosophila PDGF/VEGF receptor. [FBrf0139607] Luschnig et al., 2000, Mol. Cell 5(2): 231--241 The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases. [FBrf0128139] Zhang et al., 1999, Genetics 151(2): 697--711 A genetic screen for modifiers of Drosophila Src42A identifies mutations in egfr, rolled and a novel signaling gene. [FBrf0107534] Hou et al., 1995, Cell 81(1): 63--71 The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. [FBrf0080103] Raabe et al., 1995, EMBO J. 14(11): 2509--2518 Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila. [FBrf0082502]

Allele Dmel\drkΔP24

Allele Dmel\drk^ΔP24