Adults bearing whole-eye/antenna drkΔP24 clones have severely reduced climbing activity, suggesting defects in gravity sensing. These individuals exhibit disorganized scolopidia (as revealed by phalloidin staining, which labels cap rods, scolopale rods, and the actin bundles within the cilia of the mechanosensory neurons) and significantly smaller antennal mechanosensory motor center, indicating loss of sensory nerve terminals in the brain.
Olfactory association learning is lower in drkΔP24 heterozygotes compared to controls. There is a 20% decrease in learning after training with 6 or less pairings.
Histological and immunohistochemical examination of drke0A heterozygous heads with multiple antigenic markers does not reveal and gross structural anomalies in the brain. Avoidance of odors used as CS and electroshock (US) are no different from that of controls. Heterozygous mutants exhibit normal odor avoidance after pre-exposure to electric shock.
drkΔP24 homozygous clones in the dorsal air sac primordium are found at the tip of the primordium at a significantly lower frequency than wild-type clones.
The initiation of mesoderm spreading is unaffected in embryos derived from homozygous female germline clones.
Mutants exhibit no defects in hemocyte migration.
When mutant somatic clones are made in the border cells no effect is seen.
Embryos derived from dosP115 drkΔP24 or ShcBG drkΔP24 double mutant female germline clones have a stronger phenotype than embryos derived from either single mutant female germline clone.
Null embryos from homozygous female germlines differentiate a significant amount of cuticle. In embryos from homozygous germlines that receive a paternal wild type drk, defects in the posterior spiracles and A8, which are common in Sos mutant embryos, are rarely observed.