Allele Dmel\drk^k02401

General Information
Symbol	Dmel\drk^k02401	Species	D. melanogaster
Name		FlyBase ID	FBal0042995
Feature type	allele	Associated gene	Dmel\drk
Also Known As	k02401

Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Roch et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{lacW}drk^k02401 (BDGP Project Members, 1994-1999, Botella et al., 2003, Roch et al., 1998, Spradling et al., 1999, Dworkin and Gibson, 2006, Yan et al., 2009, Moressis et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	learning defective (Moressis et al., 2009) lethal \| recessive (Roch et al., 1998, Spradling et al., 1999, Dworkin and Gibson, 2006) visible \| dominant (Dworkin and Gibson, 2006)
Phenotype Manifest In
	wing \| posterior (Dworkin and Gibson, 2006)
Detailed Description
	Statement Reference Olfactory association learning is lower in drk[k02401] heterozygotes compared to controls. (Moressis et al., 2009) Heterozygotes show a direct effect on the shape of the wing, having a significant effect in the posterior region, but no effect in the anterior region. (Dworkin and Gibson, 2006) Lethality occurs during third instar larval or pupal stages. Mutants do not show any visible disc abnormalities. (Roch et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference drk^k02401 is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) drk^k02401 is a non-enhancer of visible phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) drk^k02401 is a non-enhancer of visible phenotype of Ret^GMR.PR (Read et al., 2005) drk^k02401 is a non-enhancer of visible phenotype of Ret^MEN2A.GMR (Read et al., 2005) drk^k02401 is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005)
Suppressor of
Statement Reference drk^k02401/drk[+] is a suppressor of visible \| dominant phenotype of Egfr^E1 (Read et al., 2005) drk^k02401 is a suppressor of visible phenotype of Ret^MEN2B.GMR (Read et al., 2005)
NOT Suppressor of
Statement Reference drk^k02401/drk[+] is a non-suppressor of increased cell number phenotype of Uba1^B1/Uba1^B2 (Yan et al., 2009) drk^k02401/drk[+] is a non-suppressor of lethal phenotype of Uba1^B1/Uba1^B2 (Yan et al., 2009) drk^k02401 is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) drk^k02401 is a non-suppressor of visible phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) drk^k02401 is a non-suppressor of visible phenotype of Ret^GMR.PR (Read et al., 2005) drk^k02401 is a non-suppressor of visible phenotype of Ret^MEN2A.GMR (Read et al., 2005) drk^k02401 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005)
Phenotype Manifest In
NOT Enhancer of
Statement Reference drk^k02401 is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) drk^k02401 is a non-enhancer of eye phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) drk^k02401 is a non-enhancer of eye phenotype of Ret^GMR.PR (Read et al., 2005) drk^k02401 is a non-enhancer of eye phenotype of Ret^MEN2A.GMR (Read et al., 2005) drk^k02401 is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005)
Suppressor of
Statement Reference drk^k02401/drk[+] is a suppressor \| partially of optic lobe \| adult stage phenotype of vap² (Botella et al., 2003) drk^k02401/drk[+] is a suppressor of eye phenotype of Egfr^E1 (Read et al., 2005) drk^k02401 is a suppressor of eye phenotype of Ret^MEN2B.GMR (Read et al., 2005)
NOT Suppressor of
Statement Reference drk^k02401 is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) drk^k02401 is a non-suppressor of eye phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) drk^k02401 is a non-suppressor of eye phenotype of Ret^GMR.PR (Read et al., 2005) drk^k02401 is a non-suppressor of eye phenotype of Ret^MEN2A.GMR (Read et al., 2005) drk^k02401 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference A drk[k02401]/+ background does not suppress the ectopic cell divisions found in Uba1[B1]/Uba1[B2] trans-heterozygous eye discs. (Yan et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	drk¹⁰⁶²⁶ (BDGP Project Members, 1994-1999) drk^k03106 (BDGP Project Members, 1994-1999) drk^unspecified (Dworkin and Gibson, 2006)
Comments
Stocks ( 2 )
Bloomington	10372 y¹ w^67c23; P{lacW}drk^k02401/CyO
Kyoto	111070 w¹¹¹⁸; P{neoFRT}42D P{lacW}drk^k02401 /CyO y⁺
Notes on Origin
Discoverer	I. Kiss.

Comments
	Complements: arr^k08131. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	24/1 (Roch et al., 1998) drk^k02401 (Dworkin and Gibson., 2006, Yan et al., 2009, Moressis et al., 2009) drk^K02401 (Settle et al., 2003) drk^P2 (Moressis et al., 2009) k02401 (Dworkin and Gibson, 2006, Dworkin et al., 2011) l(2)k02401 (Spradling et al., 1999)
Name Synonym
Secondary FlyBase IDs

References ( 15 )
Research paper	Dworkin et al., 2011, Genetics 187(4): 1171--1184 The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. [FBrf0214376] Moressis et al., 2009, J. Neurosci. 29(8): 2611--2625 A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory. [FBrf0207513] Yan et al., 2009, J. Cell Sci. 122(9): 1461--1470 Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo. [FBrf0207806] Dworkin and Gibson, 2006, Genetics 173(3): 1417--1431 Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. [FBrf0193945] Read et al., 2005, Genetics 171(3): 1057--1081 A Drosophila model of multiple endocrine neoplasia type 2. [FBrf0190765] Zhu et al., 2005, Genetics 170(2): 767--777 A screen for genes that influence fibroblast growth factor signal transduction in Drosophila. [FBrf0187664] Botella et al., 2003, Mol. Biol. Cell 14(1): 241--250 Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. [FBrf0155942] Settle et al., 2003, Oncogene 22(13): 1916--1926 Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model. [FBrf0159278] Johannes and Preiss, 2002, Mech. Dev. 115(1-2): 3--14 Wing vein formation in Drosophila melanogaster: hairless is involved in the cross-talk between Notch and EGF signaling pathways. [FBrf0149093] Sullivan and Rubin, 2002, Genetics 161(1): 183--193 The Ca(2+)-calmodulin-activated protein phosphatase calcineurin negatively regulates EGF receptor signaling in Drosophila development. [FBrf0149012] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Roch et al., 1998, Mol. Gen. Genet. 257(2): 103--112 Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. [FBrf0100624]
Supplementary material	Dworkin and Gibson., 2006, Genetics 173(3): Supplemental Figures. [FBrf0199151]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\drkk02401

Allele Dmel\drk^k02401